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Open Access 01-12-2013 | Primary research

Changes in the MALT1-A20-NF-κB expression pattern may be related to T cell dysfunction in AML

Authors: Li Shi, Shaohua Chen, Yuhong Lu, Xu Wang, Ling Xu, Fan Zhang, Lijian Yang, Xiuli Wu, Bo Li, Yangqiu Li

Published in: Cancer Cell International | Issue 1/2013

Abstract

To elucidate the characteristics of T-cell receptor (TCR) signal transduction in T-cells from acute myeloid leukemia (AML), the mucosa-associated-lymphoid-tissue lymphoma-translocation gene 1 (MALT1), A20, NF-κB and MALT1-V1 gene expression levels in CD3⁺ T cells sorted from the peripheral blood of patients with AML were analyzed by real-time PCR. A significantly lower MALT1 and A20 expression level was found in T cells from patients with AML compared with healthy controls (p = 0.045, p < 0.0001); however, the expression level of MALT1-V1 (variant 1) was significantly higher in the AML group than in the healthy control group (p = 0.006), and the expression level of NF-κB was increased in the AML group. In conclusion, the characteristics of the expression pattern of MALT1-A20-NF-κB and the distribution of MALT1 variants in T cells from AML were first characterized. Overall, low TCR-CD3 signaling is related to low MALT1 expression, which may related to T cell immunodeficiency, while the up-regulation of MALT1-V1 may play a role in overcoming the T cell activity by downregulating A20 in patients with AML, which may be related to a specific response to AML-associated antigens.

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Title: Changes in the MALT1-A20-NF-κB expression pattern may be related to T cell dysfunction in AML
Authors: Li Shi
Shaohua Chen
Yuhong Lu
Xu Wang
Ling Xu
Fan Zhang
Lijian Yang
Xiuli Wu
Bo Li
Yangqiu Li
Publication date: 01-12-2013
Publisher: BioMed Central
Published in: Cancer Cell International / Issue 1/2013
Electronic ISSN: 1475-2867
DOI: https://doi.org/10.1186/1475-2867-13-37

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