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01-10-2007 | Original Paper

Change in cerebral autoregulation as a function of time in children after severe traumatic brain injury: a case series

Authors: Nuj Tontisirin, William Armstead, Pichaya Waitayawinyu, Anne Moore, Yuthana Udomphorn, Jerry J. Zimmerman, Randall Chesnut, Monica S. Vavilala

Published in: Child's Nervous System | Issue 10/2007

Abstract

Objective

The objective of this study was to describe changes in cerebral autoregulation after severe pediatric traumatic brain injury (TBI).

Materials and methods

Two cerebral autoregulation tests were performed during the first 10 days after severe TBI in children <16 years. Cerebral autoregulation was quantified using the mean autoregulatory index (mARI).

Results

Nine (five males/four females) children (10 ± 5 years) with severe (admission Glasgow Coma Scale (GCS), 5 ± 2) TBI were enrolled. Thirty (3/9) percent of initial exams revealed impaired cerebral autoregulation; all three had returned to intact cerebral autoregulation on second exam. However, in three of nine (33%) patients, cerebral autoregulation worsened on second exam. Of the factors examined, worsening mARI on second exam was associated with worsening head computed tomography (CT) lesion.

Conclusions

Cerebral autoregulation often changed and worsened during the first 9 days after severe pediatric TBI. Worsening cerebral autoregulation may mirror worsening TBI.

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Title: Change in cerebral autoregulation as a function of time in children after severe traumatic brain injury: a case series
Authors: Nuj Tontisirin
William Armstead
Pichaya Waitayawinyu
Anne Moore
Yuthana Udomphorn
Jerry J. Zimmerman
Randall Chesnut
Monica S. Vavilala
Publication date: 01-10-2007
Publisher: Springer-Verlag
Published in: Child's Nervous System / Issue 10/2007
Print ISSN: 0256-7040
Electronic ISSN: 1433-0350
DOI: https://doi.org/10.1007/s00381-007-0339-0

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Change in cerebral autoregulation as a function of time in children after severe traumatic brain injury: a case series

Abstract

Objective

Materials and methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Objective

Materials and methods

Results

Conclusions

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