Published in:
01-11-2019 | Central Nervous System Trauma | Invited Commentary
Invited Commentary Re: Early Chemical Thromboprophylaxis does not Increase the Risk of Intracranial Hematoma Progression in Patients with Isolated Severe Traumatic Brain Injury
Author:
Elizabeth Benjamin
Published in:
World Journal of Surgery
|
Issue 11/2019
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Excerpt
Venous thromboembolic events (VTE) are a major concern after trauma, and preventative measures including early initiation of chemoprophylaxis (VTEp) are encouraged. The balance between risk of VTE and potential exacerbation of bleeding, however, is of extreme importance, especially after traumatic brain injury (TBI). Early initiation of low molecular weight heparin after TBI has repeatedly been shown using large population database cohorts, to decrease VTE and improve mortality. The use of large populations corrects for the low incidence of VTE, but there is concern that this method fails to adequately address the safety of anticoagulation and potential injury progression or functional outcome change. …