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Intensive Care Medicine
Published in: Intensive Care Medicine 1/2021

01-01-2021 | Central Nervous System Trauma | Editorial

Clinical validation of precision medicine protocols: the last mile is the longest

Authors: Michael P. Casaer, Audrey De Jong, Anders Perner

Published in: Intensive Care Medicine | Issue 1/2021

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Excerpt

Advanced understanding of the complex pathophysiology of critical illness drives the development and optimization of sophisticated therapeutic protocols with the ambition to improve short- and long-term outcomes for every patient [1]. During the last decade, individualized, titrated, precision and/or target-driven approaches have proliferated [2]. Such strategies aim to replace or supplement more generic one-size-fits-all therapies or more simple clinical titration, through detailed measurements of markers of pathophysiological derangement followed by protocolized corrective or reactive interventions. …
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Metadata
Title
Clinical validation of precision medicine protocols: the last mile is the longest
Authors
Michael P. Casaer
Audrey De Jong
Anders Perner
Publication date
01-01-2021
Publisher
Springer Berlin Heidelberg
Published in
Intensive Care Medicine / Issue 1/2021
Print ISSN: 0342-4642
Electronic ISSN: 1432-1238
DOI
https://doi.org/10.1007/s00134-020-06301-1

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