Published in:
01-05-2007 | Case Report
Celiac Disease Is Not Associated with Chronic Hepatitis C
Authors:
Thierry Thevenot, Arnaud Boruchowicz, Jean Henrion, Bernard Nalet, Henri Moindrot, ANGH
Published in:
Digestive Diseases and Sciences
|
Issue 5/2007
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Excerpt
Celiac disease (CD) is characterized by malabsorption due to a local immune response to dietary gluten against the mucosa of the small intestine in genetically predisposed patients bearing the human leukocyte antigen (HLA) DR3-DQ2 or DR4-DQ8. CD has a wide spectrum of gastrointestinal and extraintestinal manifestations, including dermatitis herpetiformis, type 1 diabetes mellitus, and autoimmune thyroiditis [
1]. It has been hypothesized that hepatitis C virus (HCV) may trigger immunologic gluten intolerance in susceptible people [
2]. However, this assumption is still a matter of debate. Recently, we diagnosed four patients having both CD and chronic hepatitis C, three of them having a well-defined route of transmission, suggesting that there is no obvious link between the two diseases. …