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Published in:

01-02-2017 | Invited Article

Celiac disease: a clinical review

Authors: Badr Al-Bawardy, D. Chamil Codipilly, Alberto Rubio-Tapia, David H. Bruining, Stephanie L. Hansel, Joseph A. Murray

Published in: Abdominal Radiology | Issue 2/2017

Abstract

Celiac disease (CD) is an immune-mediated inflammatory enteropathy triggered by gluten exposure in genetically susceptible individuals. It has a high prevalence approaching 1% of the US population. A high index of suspicion is warranted to diagnose CD as frequently patients present with extraintestinal or atypical manifestations. CD is diagnosed by a combination of serum serologies and duodenal biopsies. The majority of patients will respond to a lifelong gluten-free diet which is the cornerstone of therapy. Complications such as refractory CD, ulcerative jejunoileitis, enteropathy associated T-cell lymphoma and small bowel adenocarcinoma occur in a minority of patients.

Fasano A, Berti I, Gerarduzzi T, et al. (2003) Prevalence of celiac disease in at-risk and not-at-risk groups in the United States: a large multicenter study. Arch Intern Med 163(3):286–292PubMedCrossRef

Rubio-Tapia A, Ludvigsson JF, Brantner TL, Murray JA, Everhart JE (2012) The prevalence of celiac disease in the United States. Am J Gastroenterol 107(10):1538–1544 (quiz 1537). doi:10.1038/ajg.2012.219 PubMedCrossRef

Kim HS, Patel KG, Orosz E, et al. (2016) Time trends in the prevalence of celiac disease and gluten-free diet in the US population: results from the National Health and Nutrition Examination surveys 2009–2014. JAMA Intern Med 176(111):1716–1717PubMedCrossRef

Choung RS, Ditah IC, Nadeau AM, et al. (2015) Trends and racial/ethnic disparities in gluten-sensitive problems in the United States: findings from the National Health and Nutrition Examination Surveys from 1988 to 2012. Am J Gastroenterol 110(3):455–461. doi:10.1038/ajg.2015.8 PubMedCrossRef

Tommasini A, Not T, Kiren V, et al. (2004) Mass screening for coeliac disease using antihuman transglutaminase antibody assay. Arch Dis Child 89(6):512–515PubMedPubMedCentralCrossRef

Catassi C, Fanciulli G, D’Appello AR, et al. (2000) Antiendomysium versus antigliadin antibodies in screening the general population for coeliac disease. Scand J Gastroenterol 35(7):732–736PubMedCrossRef

Trevisiol C, Not T, Berti I, et al. (1999) Screening for coeliac disease in healthy blood donors at two immuno-transfusion centres in north-east Italy. Ital J Gastroenterol Hepatol 31(7):584–586PubMed

Volta U, Bellentani S, Bianchi FB, et al. (2001) High prevalence of celiac disease in Italian general population. Dig Dis Sci 46(7):1500–1505PubMedCrossRef

West J, Logan RF, Hill PG, et al. (2003) Seroprevalence, correlates, and characteristics of undetected coeliac disease in England. Gut 52(7):960–965PubMedPubMedCentralCrossRef

10.

Carlsson AK, Axelsson IE, Borulf SK, Bredberg AC, Ivarsson SA (2001) Serological screening for celiac disease in healthy 2.5-year-old children in Sweden. Pediatrics 107(1):42–45PubMedCrossRef

11.

Walker MM, Murray JA, Ronkainen J, et al. (2010) Detection of celiac disease and lymphocytic enteropathy by parallel serology and histopathology in a population-based study. Gastroenterology 139(1):112–119. doi:10.1053/j.gastro.2010.04.007 PubMedPubMedCentralCrossRef

12.

Kolho KL, Farkkila MA, Savilahti E (1998) Undiagnosed coeliac disease is common in Finnish adults. Scand J Gastroenterol 33(12):1280–1283PubMedCrossRef

13.

Mäki M, Mustalahti K, Kokkonen J, et al. (2003) Prevalence of celiac disease among children in Finland. N Engl J Med 348(25):2517–2524. doi:10.1056/NEJMoa021687 PubMedCrossRef

14.

Csizmadia CGDS, Mearin ML, von Blomberg BME, Brand R, Verloove-Vanhorick SP (1999) An iceberg of childhood coeliac disease in the Netherlands. Lancet 353(9155):813–814. doi:10.1016/S0140-6736(99)00243-3 PubMedCrossRef

15.

Catassi C, Ratsch IM, Gandolfi L, et al. (1999) Why is coeliac disease endemic in the people of the Sahara? Lancet (London, England) 354(9179):647–648CrossRef

16.

Barada K, Bitar A, Mokadem MA, Hashash JG, Green P (2010) Celiac disease in Middle Eastern and North African countries: a new burden? World J Gastroenterol 16(12):1449–1457PubMedPubMedCentralCrossRef

17.

Rewers M (2005) Epidemiology of celiac disease: what are the prevalence, incidence, and progression of celiac disease? Gastroenterology 128(4 Suppl 1):S47–S51PubMedCrossRef

18.

Cummins AG, Roberts-Thomson IC (2009) Prevalence of celiac disease in the Asia-Pacific region. J Gastroenterol Hepatol 24(8):1347–1351. doi:10.1111/j.1440-1746.2009.05932.x PubMedCrossRef

19.

Abadie V, Sollid LM, Barreiro LB, Jabri B (2011) Integration of genetic and immunological insights into a model of celiac disease pathogenesis. Annu Rev Immunol 29:493–525PubMedCrossRef

20.

Tack GJ, Verbeek WH, Schreurs MW, Mulder CJ (2010) The spectrum of celiac disease: epidemiology, clinical aspects and treatment. Nat Rev Gastroenterol Hepatol 7(4):204–213. doi:10.1038/nrgastro.2010.23 PubMedCrossRef

21.

Murray JA, Van Dyke C, Plevak MF, et al. (2003) Trends in the identification and clinical features of celiac disease in a North American community, 1950–2001. Clin Gastroenterol Hepatol 1(1):19–27. doi:10.1053/jcgh.2003.50004 PubMedCrossRef

22.

Ludvigsson JF, Rubio-Tapia A, van Dyke CT, et al. (2013) Increasing incidence of celiac disease in a North American population. Am J Gastroenterol 108(5):818–824. doi:10.1038/ajg.2013.60 PubMedPubMedCentralCrossRef

23.

Riddle MS, Murray JA, Porter CK (2012) The incidence and risk of celiac disease in a healthy US adult population. Am J Gastroenterol 107(8):1248–1255. doi:10.1038/ajg.2012.130 PubMedPubMedCentralCrossRef

24.

Dixit R, Lebwohl B, Ludvigsson JF, et al. (2014) Celiac disease is diagnosed less frequently in young adult males. Dig Dis Sci 59(7):1509–1512. doi:10.1007/s10620-014-3025-6 PubMedCrossRef

25.

Green PHR, Stavropoulos SN, Panagi SG, et al. (2001) Characteristics of adult celiac disease in the USA: results of a national survey. Am J Gastroenterol 96(1):126–131. doi:10.1111/j.1572-0241.2001.03462.x PubMedCrossRef

26.

Dogan Y, Yildirmaz S, Ozercan IH (2012) Prevalence of celiac disease among first-degree relatives of patients with celiac disease. J Pediatr Gastroenterol Nutr 55(2):205–208. doi:10.1097/MPG.0b013e318249378c PubMedCrossRef

27.

Ploski R, Ek J, Thorsby E, Sollid LM (1993) On the HLA-DQ(alpha 1*0501, beta 1*0201)-associated susceptibility in celiac disease: a possible gene dosage effect of DQB1*0201. Tissue Antigens 41(4):173–177PubMedCrossRef

28.

Rubio-Tapia A, Van Dyke CT, Lahr BD, et al. (2008) Predictors of family risk for celiac disease: a population-based study. Clin Gastroenterol Hepatol 6(9):983–987. doi:10.1016/j.cgh.2008.04.008 PubMedPubMedCentralCrossRef

29.

Greco L, Romino R, Coto I, et al. (2002) The first large population based twin study of coeliac disease. Gut 50(5):624–628PubMedPubMedCentralCrossRef

30.

Karell K, Louka AS, Moodie SJ, et al. (2003) HLA types in celiac disease patients not carrying the DQA1*05-DQB1*02 (DQ2) heterodimer: results from the European Genetics Cluster on Celiac Disease. Hum Immunol 64(4):469–477PubMedCrossRef

31.

Hadithi M, von Blomberg BM, Crusius JB, et al. (2007) Accuracy of serologic tests and HLA-DQ typing for diagnosing celiac disease. Ann Intern Med 147(5):294–302PubMedCrossRef

32.

Lebwohl B, Rubio-Tapia A, Assiri A, Newland C, Guandalini S (2012) Diagnosis of celiac disease. Gastrointest Endosc Clin N Am 22(4):661–677. doi:10.1016/j.giec.2012.07.004 PubMedPubMedCentralCrossRef

33.

Sollid LM, Thorsby E (1990) The primary association of celiac disease to a given HLA-DQ alpha/beta heterodimer explains the divergent HLA-DR associations observed in various Caucasian populations. Tissue Antigens 36(3):136–137PubMedCrossRef

34.

Trynka G, Zhernakova A, Romanos J, et al. (2009) Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling. Gut 58(8):1078–1083. doi:10.1136/gut.2008.169052 PubMedCrossRef

35.

Garner CP, Murray JA, Ding YC, et al. (2009) Replication of celiac disease UK genome-wide association study results in a US population. Hum Mol Genet 18(21):4219–4225. doi:10.1093/hmg/ddp364 PubMedPubMedCentralCrossRef

36.

Vriezinga SL, Auricchio R, Bravi E, et al. (2014) Randomized feeding intervention in infants at high risk for celiac disease. N Engl J Med 371(14):1304–1315PubMedCrossRef

37.

Lionetti E, Castellaneta S, Francavilla R, et al. (2014) Introduction of gluten, HLA status, and the risk of celiac disease in children. N Engl J Med 371(14):1295–1303PubMedCrossRef

38.

Andren Aronsson C, Lee HS, Koletzko S, et al. (2016) Effects of gluten intake on risk of celiac disease: a case–control study on a Swedish Birth cohort. Clin Gastroenterol Hepatol 14(3):403–409PubMedCrossRef

39.

Marild K, Stephansson O, Montgomery S, Murray JA, Ludvigsson JF (2012) Pregnancy outcome and risk of celiac disease in offspring: a nationwide case–control study. Gastroenterology 142(1):39–45PubMedCrossRef

40.

Marild K, Ye W, Lebwohl B, et al. (2013) Antibiotic exposure and the development of coeliac disease: a nationwide case–control study. BMC Gastroenterol 13(109):13–109

41.

Ludvigsson JF, Nordenvall C, Jarvholm B (2014) Smoking, use of moist snuff and risk of celiac disease: a prospective study. BMC Gastroenterol 14(120):14–120

42.

Patel AH, Loftus EV, Murray JA, et al. (2001) Cigarette smoking and celiac sprue: a case–control study. Am J Gastroenterol 96(8):2388–2391PubMedCrossRef

43.

Binder HJ (2015) Disorders of absorption. In: Kasper D, Fauci A, Hauser S, Longo D, Jameson JL, Loscalzo J (eds) Harrison’s principles of internal medicine, 19th edn. New York: McGraw-Hill Education

44.

S G (1890) On the coeliac affection. St Bart Hosp Rep: 2417–2420

45.

Rashid M, Cranney A, Zarkadas M, et al. (2005) Celiac disease: evaluation of the diagnosis and dietary compliance in Canadian children. Pediatrics 116(6):e754–e759. doi:10.1542/peds.2005-0904 PubMedCrossRef

46.

Telega G, Bennet TR, Werlin S (2008) Emerging new clinical patterns in the presentation of celiac disease. Arch Pediatr Adolesc Med 162(2):164–168. doi:10.1001/archpediatrics.2007.38 PubMedCrossRef

47.

Guandalini S, Assiri A (2014) Celiac disease: a review. JAMA Pediatr 168(3):272–278. doi:10.1001/jamapediatrics.2013.3858 PubMedCrossRef

48.

Skowera A, Peakman M, Cleare A, et al. (2001) High prevalence of serum markers of coeliac disease in patients with chronic fatigue syndrome. J Clin Pathol 54(4):335–336PubMedPubMedCentralCrossRef

49.

Sanders DS, Patel D, Stephenson TJ, et al. (2003) A primary care cross-sectional study of undiagnosed adult coeliac disease. Eur J Gastroenterol Hepatol 15(4):407–413PubMedCrossRef

50.

Halfdanarson TR, Litzow MR, Murray JA (2007) Hematologic manifestations of celiac disease. Blood 109(2):412–421. doi:10.1182/blood-2006-07-031104 PubMedPubMedCentralCrossRef

51.

Hanif FM, Luck NH, Abbas Z, et al. (2015) Early, non-refractory celiac disease associated with microscopic colitis and splenomegaly. J Coll Phys Surg-Pakistan 25(Suppl 1):S14–S16

52.

Sadr-Azodi O, Sanders DS, Murray JA, Ludvigsson JF (2012) Patients with celiac disease have an increased risk for pancreatitis. Clin Gastroenterol Hepatol 10(10):1136–1142PubMedPubMedCentralCrossRef

53.

Briggs JH, McKean D, Palmer JS, Bungay H (2014) Transient small bowel intussusception in adults: an overlooked feature of coeliac disease. BMJ Case Rep 20(10):2013–203156

54.

Jakes AD, Bradley S, Donlevy L (2014) Dermatitis herpetiformis. BMJ 348:g2557. doi:10.1136/bmj.g2557 PubMedCrossRef

55.

Collin P, Reunala T, Rasmussen M, et al. (1997) High incidence and prevalence of adult coeliac disease. Augmented diagnostic approach. Scand J Gastroenterol 32(11):1129–1133PubMedCrossRef

56.

Caproni M, Bonciolini V, D’Errico A, Antiga E, Fabbri P (2012) Celiac disease and dermatologic manifestations: many skin clue to unfold gluten-sensitive enteropathy. Gastroenterol Res Pract 2012:952753. doi:10.1155/2012/952753 PubMedPubMedCentralCrossRef

57.

Freeman HJ (2008) Neurological disorders in adult celiac disease. Can J Gastroenterol 22(11):909–911PubMedPubMedCentralCrossRef

58.

Fisher AH, Lomasky SJ, Fisher MJ, Oppenheim YL (2008) Celiac disease and the endocrinologist: a diagnostic opportunity. Endocr Pract 14(3):381–388. doi:10.4158/ep.14.3.381 PubMedCrossRef

59.

Ludvigsson JF, Sellgren C, Runeson B, Langstrom N, Lichtenstein P (2011) Increased suicide risk in coeliac disease—a Swedish nationwide cohort study. Dig Liver Dis 43(8):616–622. doi:10.1016/j.dld.2011.02.009 PubMedCrossRef

60.

Rubio-Tapia A, Hill ID, Kelly CP, Calderwood AH, Murray JA (2013) ACG clinical guidelines: diagnosis and management of celiac disease. Am J Gastroenterol 108(5):656–676 (quiz 677). doi:10.1038/ajg.2013.79 PubMedPubMedCentralCrossRef

61.

Lewis NR, Scott BB (2010) Meta-analysis: deamidated gliadin peptide antibody and tissue transglutaminase antibody compared as screening tests for coeliac disease. Aliment Pharmacol Ther 31(1):73–81. doi:10.1111/j.1365-2036.2009.04110.x PubMedCrossRef

62.

Giersiepen K, Lelgemann M, Stuhldreher N, et al. (2012) Accuracy of diagnostic antibody tests for coeliac disease in children: summary of an evidence report. J Pediatr Gastroenterol Nutr 54(2):229–241. doi:10.1097/MPG.0b013e318216f2e5 PubMedCrossRef

63.

Amarri S, Alvisi P, De Giorgio R, et al. (2013) Antibodies to deamidated gliadin peptides: an accurate predictor of coeliac disease in infancy. J Clin Immunol 33(5):1027–1030. doi:10.1007/s10875-013-9888-z PubMedCrossRef

64.

McGowan KE, Lyon ME, Butzner JD (2008) Celiac disease and IgA deficiency: complications of serological testing approaches encountered in the clinic. Clin Chem 54(7):1203–1209. doi:10.1373/clinchem.2008.103606 PubMedCrossRef

65.

Lee SK, Green PH (2005) Endoscopy in celiac disease. Curr Opin Gastroenterol 21(5):589–594PubMedCrossRef

66.

Dickson BC, Streutker CJ, Chetty R (2006) Coeliac disease: an update for pathologists. J Clin Pathol 59(10):1008–1016. doi:10.1136/jcp.2005.035345 PubMedPubMedCentralCrossRef

67.

Oberhuber G (2000) Histopathology of celiac disease. Biomed Pharmacother 54(7):368–372. doi:10.1016/s0753-3322(01)80003-2 PubMedCrossRef

68.

Corazza GR, Villanacci V, Zambelli C, et al. (2007) Comparison of the interobserver reproducibility with different histologic criteria used in celiac disease. Clin Gastroenterol Hepatol 5(7):838–843. doi:10.1016/j.cgh.2007.03.019 PubMedCrossRef

69.

Husby S, Koletzko S, Korponay-Szabo IR, et al. (2012) European Society for Pediatric Gastroenterology, Hepatology, and Nutrition guidelines for the diagnosis of coeliac disease. J Pediatr Gastroenterol Nutr 54(1):136–160. doi:10.1097/MPG.0b013e31821a23d0 PubMedCrossRef

70.

Kurppa K, Salminiemi J, Ukkola A, et al. (2012) Utility of the new ESPGHAN criteria for the diagnosis of celiac disease in at-risk groups. J Pediatr Gastroenterol Nutr 54(3):387–391. doi:10.1097/MPG.0b013e3182407c6b PubMedCrossRef

71.

Klapp G, Masip E, Bolonio M, et al. (2013) Celiac disease: the new proposed ESPGHAN diagnostic criteria do work well in a selected population. J Pediatr Gastroenterol Nutr 56(3):251–256. doi:10.1097/MPG.0b013e318279887b PubMedCrossRef

72.

Mubarak A, Wolters VM, Gerritsen SA, et al. (2011) A biopsy is not always necessary to diagnose celiac disease. J Pediatr Gastroenterol Nutr 52(5):554–557. doi:10.1097/MPG.0b013e3181ef8e50 PubMedCrossRef

73.

Barker CC, Mitton C, Jevon G, Mock T (2005) Can tissue transglutaminase antibody titers replace small-bowel biopsy to diagnose celiac disease in select pediatric populations? Pediatrics 115(5):1341–1346. doi:10.1542/peds.2004-1392 PubMedCrossRef

74.

Alessio MG, Tonutti E, Brusca I, et al. (2012) Correlation between IgA tissue transglutaminase antibody ratio and histological finding in celiac disease. J Pediatr Gastroenterol Nutr 55(1):44–49. doi:10.1097/MPG.0b013e3182470249 PubMedCrossRef

75.

Donaldson MR, Book LS, Leiferman KM, Zone JJ, Neuhausen SL (2008) Strongly positive tissue transglutaminase antibodies are associated with Marsh 3 histopathology in adult and pediatric celiac disease. J Clin Gastroenterol 42(3):256–260. doi:10.1097/MCG.0b013e31802e70b1 PubMed

76.

Trovato CM, Montuori M, Anania C, et al. (2015) Are ESPGHAN “biopsy-sparing” guidelines for celiac disease also suitable for asymptomatic patients? Am J Gastroenterol 110(10):1485–1489. doi:10.1038/ajg.2015.285 PubMedCrossRef

77.

Saginur M, AlRefaee FAM, Spady DW, et al. (2013) Antitissue transglutaminase antibody determination versus upper endoscopic biopsy diagnosis of paediatric celiac disease. Paediatr Child Health 18(5):246–250

78.

Wakim-Fleming J, Pagadala MR, Lemyre MS, et al. (2013) Diagnosis of celiac disease in adults based on serology test results, without small-bowel biopsy. Clin Gastroenterol Hepatol 11(5):511–516. doi:10.1016/j.cgh.2012.12.015 PubMedCrossRef

79.

Salmi TT, Collin P, Reunala T, Maki M, Kaukinen K (2010) Diagnostic methods beyond conventional histology in coeliac disease diagnosis. Dig Liver Dis 42(1):28–32. doi:10.1016/j.dld.2009.04.004 PubMedCrossRef

80.

Catassi C, Fasano A (2010) Celiac disease diagnosis: simple rules are better than complicated algorithms. Am J Med 123(8):691–693. doi:10.1016/j.amjmed.2010.02.019 PubMedCrossRef

81.

Rubio-Tapia A, Rahim MW, See JA, et al. (2010) Mucosal recovery and mortality in adults with celiac disease after treatment with a gluten-free diet. Am J Gastroenterol 105(6):1412–1420. doi:10.1038/ajg.2010.10 PubMedPubMedCentralCrossRef

82.

Megiorni F, Pizzuti A (2012) HLA-DQA1 and HLA-DQB1 in Celiac disease predisposition: practical implications of the HLA molecular typing. J Biomed Sci 19:88. doi:10.1186/1423-0127-19-88 PubMedPubMedCentralCrossRef

83.

Kaukinen K, Partanen J, Mäki M, Collin P (2002) HLA-DQ typing in the diagnosis of celiac disease. Am J Gastroenterol 97(3):695–699. doi:10.1016/S0002-9270(01)04033-3 PubMedCrossRef

84.

Lauret E, Rodrigo L (2013) Celiac disease and autoimmune-associated conditions. BioMed Res Int 2013:127589. doi:10.1155/2013/127589 PubMedPubMedCentralCrossRef

85.

Poulain C, Johanet C, Delcroix C, Levy-Marchal C, Tubiana-Rufi N (2007) Prevalence and clinical features of celiac disease in 950 children with type 1 diabetes in France. Diabetes Metab 33(6):453–458. doi:10.1016/j.diabet.2007.06.004 PubMedCrossRef

86.

Pham-Short A, Donaghue KC, Ambler G, et al. (2015) Screening for celiac disease in type 1 diabetes: a systematic review. Pediatrics 136(1):e170–e176PubMedCrossRef

87.

Hadithi M, de Boer H, Meijer JW, et al. (2007) Coeliac disease in Dutch patients with Hashimoto’s thyroiditis and vice versa. World J Gastroenterol 13(11):1715–1722PubMedPubMedCentralCrossRef

88.

Sategna-Guidetti C, Volta U, Ciacci C, et al. (2001) Prevalence of thyroid disorders in untreated adult celiac disease patients and effect of gluten withdrawal: an Italian multicenter study. Am J Gastroenterol 96(3):751–757. doi:10.1111/j.1572-0241.2001.03617.x PubMedCrossRef

89.

Ansaldi N, Palmas T, Corrias A, et al. (2003) Autoimmune thyroid disease and celiac disease in children. J Pediatr Gastroenterol Nutr 37(1):63–66PubMedCrossRef

90.

Elfstrom P, Montgomery SM, Kampe O, Ekbom A, Ludvigsson JF (2008) Risk of thyroid disease in individuals with celiac disease. J Clin Endocrinol Metab 93(10):3915–3921. doi:10.1210/jc.2008-0798 PubMedCrossRef

91.

Meloni A, Mandas C, Jores RD, Congia M (2009) Prevalence of autoimmune thyroiditis in children with celiac disease and effect of gluten withdrawal. J Pediatr 155(1):51–55, 55.e51. doi:10.1016/j.jpeds.2009.01.013

92.

Kingham JG, Parker DR (1998) The association between primary biliary cirrhosis and coeliac disease: a study of relative prevalences. Gut 42(1):120–122PubMedPubMedCentralCrossRef

93.

Floreani A, Betterle C, Baragiotta A, et al. (2002) Prevalence of coeliac disease in primary biliary cirrhosis and of antimitochondrial antibodies in adult coeliac disease patients in Italy. Dig Liver Dis 34(4):258–261PubMedCrossRef

94.

Ludvigsson JF, Elfstrom P, Broome U, Ekbom A, Montgomery SM (2007) Celiac disease and risk of liver disease: a general population-based study. Clin Gastroenterol Hepatol 5(1):63–69.e61. doi:10.1016/j.cgh.2006.09.034 PubMedCrossRef

95.

Rubio-Tapia A, Herman ML, Ludvigsson JF, et al. (2012) Severe spruelike enteropathy associated with olmesartan. Mayo Clin Proc 87(8):732–738. doi:10.1016/j.mayocp.2012.06.003 PubMedPubMedCentralCrossRef

96.

DeGaetani M, Tennyson CA, Lebwohl B, et al. (2013) Villous atrophy and negative celiac serology: a diagnostic and therapeutic dilemma. Am J Gastroenterol 108(5):647–653. doi:10.1038/ajg.2013.45 PubMedCrossRef

97.

Akobeng AK, Thomas AG (2008) Systematic review: tolerable amount of gluten for people with coeliac disease. Aliment Pharmacol Ther 27(11):1044–1052. doi:10.1111/j.1365-2036.2008.03669.x PubMedCrossRef

98.

Catassi C, Rossini M, Rätsch IM, et al. (1993) Dose dependent effects of protracted ingestion of small amounts of gliadin in coeliac disease children: a clinical and jejunal morphometric study. Gut 34(11):1515–1519PubMedPubMedCentralCrossRef

99.

Catassi C, Fabiani E, Iacono G, et al. (2007) A prospective, double-blind, placebo-controlled trial to establish a safe gluten threshold for patients with celiac disease. Am J Clin Nutr 85(1):160–166PubMed

100.

Standard for Foods for Special Dietary Use for Persons Intolerant to Gluten. Codex Committee on Nutrition and Foods for Special Dietary Uses, vol Adopted in 1979. Amendment: 1983 and 2015. Revision: 2008.

101.

Janatuinen EK, Kemppainen TA, Julkunen RJ, et al. (2002) No harm from five year ingestion of oats in coeliac disease. Gut 50(3):332–335PubMedPubMedCentralCrossRef

102.

Sey MS, Parfitt J, Gregor J (2011) Prospective study of clinical and histological safety of pure and uncontaminated Canadian oats in the management of celiac disease. JPEN J Parenter Enteral Nutr 35(4):459–464. doi:10.1177/0148607110387800 PubMedCrossRef

103.

Kemppainen TA, Heikkinen MT, Ristikankare MK, Kosma VM, Julkunen RJ (2010) Nutrient intakes during diets including unkilned and large amounts of oats in celiac disease. Eur J Clin Nutr 64(1):62–67. doi:10.1038/ejcn.2009.113 PubMedCrossRef

104.

Thompson T, Dennis M, Higgins LA, Lee AR, Sharrett MK (2005) Gluten-free diet survey: are Americans with coeliac disease consuming recommended amounts of fibre, iron, calcium and grain foods? J Hum Nutr Diet 18(3):163–169. doi:10.1111/j.1365-277X.2005.00607.x PubMedCrossRef

105.

Pink IJ, Creamer B (1967) Response to a gluten-free diet of patients with the coeliac syndrome. Lancet 1(7485):300–304PubMedCrossRef

106.

Rashtak S, Murray JA (2012) Review article: celiac disease, new approaches to therapy. Aliment Pharmacol Ther 35(7):768–781. doi:10.1111/j.1365-2036.2012.05013.x PubMedPubMedCentralCrossRef

107.

Leffler DA, Dennis M, Hyett B, et al. (2007) Etiologies and predictors of diagnosis in nonresponsive celiac disease. Clin Gastroenterol Hepatol 5(4):445–450PubMedCrossRef

108.

O’Mahony S, Howdle PD, Losowsky MS (1996) Review article: management of patients with non-responsive coeliac disease. Aliment Pharmacol Ther 10(5):671–680PubMedCrossRef

109.

Abdulkarim AS, Burgart LJ, See J, Murray JA (2002) Etiology of nonresponsive celiac disease: results of a systematic approach. Am J Gastroenterol 97(8):2016–2021PubMedCrossRef

110.

van Gils T, Nijeboer P, van Wanrooij RL, Bouma G, Mulder CJ (2015) Mechanisms and management of refractory coeliac disease. Nat Rev Gastroenterol Hepatol 12(10):572–579PubMedCrossRef

111.

Roshan B, Leffler DA, Jamma S, et al. (2011) The incidence and clinical spectrum of refractory celiac disease in a north american referral center. Am J Gastroenterol 106(5):923–928PubMedCrossRef

112.

Rubio-Tapia A, Murray JA (2010) Classification and management of refractory coeliac disease. Gut 59(4):547–557PubMedPubMedCentralCrossRef

113.

Malamut G, Afchain P, Verkarre V, et al. (2009) Presentation and long-term follow-up of refractory celiac disease: comparison of type I with type II. Gastroenterology 136(1):81–90PubMedCrossRef

114.

Rubio-Tapia A, Kelly DG, Lahr BD, et al. (2009) Clinical staging and survival in refractory celiac disease: a single center experience. Gastroenterology 136(1):99–107PubMedCrossRef

115.

Al-Toma A, Verbeek WH, Hadithi M, von Blomberg BM, Mulder CJ (2007) Survival in refractory coeliac disease and enteropathy-associated T-cell lymphoma: retrospective evaluation of single-centre experience. Gut 56(10):1373–1378PubMedPubMedCentralCrossRef

116.

Delabie J, Holte H, Vose JM, et al. (2011) Enteropathy-associated T-cell lymphoma: clinical and histological findings from the international peripheral T-cell lymphoma project. Blood 118(1):148–155PubMedCrossRef

117.

Sieniawski M, Angamuthu N, Boyd K, et al. (2010) Evaluation of enteropathy-associated T-cell lymphoma comparing standard therapies with a novel regimen including autologous stem cell transplantation. Blood 115(18):3664–3670PubMedCrossRef

118.

Siegel RL, Miller KD, Jemal A (2016) Cancer statistics. CA Cancer J Clin 66(1):7–30PubMedCrossRef

119.

Askling J, Linet M, Gridley G, et al. (2002) Cancer incidence in a population-based cohort of individuals hospitalized with celiac disease or dermatitis herpetiformis. Gastroenterology 123(5):1428–1435PubMedCrossRef

120.

Brousse N, Meijer JW (2005) Malignant complications of coeliac disease. Best Pract Res Clin Gastroenterol 19(3):401–412PubMedCrossRef

121.

Zar N, Holmberg L, Wilander E, Rastad J (1996) Survival in small intestinal adenocarcinoma. Eur J Cancer 12(9):2114–2119CrossRef

122.

Potter DD, Murray JA, Donohue JH, et al. (2004) The role of defective mismatch repair in small bowel adenocarcinoma in celiac disease. Cancer Res 64(19):7073–7077. doi:10.1158/0008-5472.can-04-1096 PubMedCrossRef

123.

Castillo NE, Vanga RR, Theethira TG, et al. (2015) Prevalence of abnormal liver function tests in celiac disease and the effect of a gluten-free diet in the US population. Am J Gastroenterol 110(8):1216–1222. doi:10.1038/ajg.2015.192 PubMedCrossRef

124.

Sainsbury A, Sanders DS, Ford AC (2011) Meta-analysis: coeliac disease and hypertransaminasaemia. Aliment Pharmacol Ther 34(1):33–40. doi:10.1111/j.1365-2036.2011.04685.x PubMedCrossRef

125.

Vajro P, Paolella G, Maggiore G, Giordano G (2013) Pediatric celiac disease, cryptogenic hypertransaminasemia, and autoimmune hepatitis. J Pediatr Gastroenterol Nutr 56(6):663–670. doi:10.1097/MPG.0b013e31828dc5c5 PubMedCrossRef

126.

Pastore L, Carroccio A, Compilato D, et al. (2008) Oral manifestations of celiac disease. J Clin Gastroenterol 42(3):224–232. doi:10.1097/MCG.0b013e318074dd98 PubMed

127.

Ch’ng CL, Jones MK, Kingham JG (2007) Celiac disease and autoimmune thyroid disease. Clin Med Res 5(3):184–192. doi:10.3121/cmr.2007.738 PubMedPubMedCentralCrossRef

128.

Betterle C, Lazzarotto F, Spadaccino AC, et al. (2006) Celiac disease in North Italian patients with autoimmune Addison’s disease. Eur J Endocrinol 154(2):275–279. doi:10.1530/eje.1.02089 PubMedCrossRef

129.

Iltanen S, Collin P, Korpela M, et al. (1999) Celiac disease and markers of celiac disease latency in patients with primary Sjogren’s syndrome. Am J Gastroenterol 94(4):1042–1046. doi:10.1111/j.1572-0241.1999.01011.x PubMed

130.

Szodoray P, Barta Z, Lakos G, Szakall S, Zeher M (2004) Coeliac disease in Sjogren’s syndrome—a study of 111 Hungarian patients. Rheumatol Int 24(5):278–282. doi:10.1007/s00296-003-0360-x PubMedCrossRef

131.

Ludvigsson JF, Rubio-Tapia A, Chowdhary V, Murray JA, Simard JF (2012) Increased risk of systemic lupus erythematosus in 29,000 patients with biopsy-verified celiac disease. J Rheumatol 39(10):1964–1970. doi:10.3899/jrheum.120493 PubMedPubMedCentralCrossRef

132.

Hwang E, McBride R, Neugut AI, Green PH (2008) Sarcoidosis in patients with celiac disease. Dig Dis Sci 53(4):977–981. doi:10.1007/s10620-007-9974-2 PubMedCrossRef

133.

Dahan S, Shor DB, Comaneshter D, et al. (2016) All disease begins in the gut: celiac disease co-existence with SLE. Autoimmun Rev 15(8):848–853. doi:10.1016/j.autrev.2016.06.003 PubMedCrossRef

134.

Rutherford RM, Brutsche MH, Kearns M, et al. (2004) Prevalence of coeliac disease in patients with sarcoidosis. Eur J Gastroenterol Hepatol 16(9):911–915PubMedCrossRef

135.

Lerner A, Matthias T (2015) Rheumatoid arthritis-celiac disease relationship: joints get that gut feeling. Autoimmun Rev 14(11):1038–1047. doi:10.1016/j.autrev.2015.07.007 PubMedCrossRef

136.

Sorensen HT, Thulstrup AM, Blomqvist P, et al. (1999) Risk of primary biliary liver cirrhosis in patients with coeliac disease: Danish and Swedish cohort data. Gut 44(5):736–738PubMedPubMedCentralCrossRef

137.

Muratori P, Fabbri A, Lalanne C, Lenzi M, Muratori L (2015) Autoimmune liver disease and concomitant extrahepatic autoimmune disease. Eur J Gastroenterol Hepatol 27(10):1175–1179. doi:10.1097/meg.0000000000000424 PubMedCrossRef

138.

van Gerven NM, Bakker SF, de Boer YS, et al. (2014) Seroprevalence of celiac disease in patients with autoimmune hepatitis. Eur J Gastroenterol Hepatol 26(10):1104–1107. doi:10.1097/meg.0000000000000172 PubMedCrossRef

139.

Stewart M, Andrews CN, Urbanski S, Beck PL, Storr M (2011) The association of coeliac disease and microscopic colitis: a large population-based study. Aliment Pharmacol Ther 33(12):1340–1349. doi:10.1111/j.1365-2036.2011.04666.x PubMedCrossRef

140.

Kochhar R, Masoodi I, Dutta U, et al. (2009) Celiac disease and Budd Chiari syndrome: report of a case with review of literature. Eur J Gastroenterol Hepatol 21(9):1092–1094. doi:10.1097/MEG.0b013e328328f47f PubMedCrossRef

141.

Ludvigsson JF, West J, Card T, Appelros P (2012) Risk of stroke in 28,000 patients with celiac disease: a nationwide cohort study in Sweden. J Stroke Cerebrovasc Dis 21(8):860–867. doi:10.1016/j.jstrokecerebrovasdis.2011.05.008 PubMedCrossRef

142.

Ciacci C, Tortora R, Scudiero O, et al. (2009) Early pregnancy loss in celiac women: the role of genetic markers of thrombophilia. Dig Liver Dis 41(10):717–720. doi:10.1016/j.dld.2009.02.050 PubMedCrossRef

143.

Malamut G, Chandesris O, Verkarre V, et al. (2013) Enteropathy associated T cell lymphoma in celiac disease: a large retrospective study. Dig Liver Dis 45(5):377–384. doi:10.1016/j.dld.2012.12.001 PubMedCrossRef

144.

Emilsson L, Lebwohl B, Sundstrom J, Ludvigsson JF (2015) Cardiovascular disease in patients with coeliac disease: a systematic review and meta-analysis. Dig Liver Dis 47(10):847–852. doi:10.1016/j.dld.2015.06.004 PubMedCrossRef

145.

Emilsson L, Smith JG, West J, Melander O, Ludvigsson JF (2011) Increased risk of atrial fibrillation in patients with coeliac disease: a nationwide cohort study. Eur Heart J 32(19):2430–2437. doi:10.1093/eurheartj/ehr167 PubMedCrossRef

Title: Celiac disease: a clinical review
Authors: Badr Al-Bawardy
D. Chamil Codipilly
Alberto Rubio-Tapia
David H. Bruining
Stephanie L. Hansel
Joseph A. Murray
Publication date: 01-02-2017
Publisher: Springer US
Published in: Abdominal Radiology / Issue 2/2017
Print ISSN: 2366-004X
Electronic ISSN: 2366-0058
DOI: https://doi.org/10.1007/s00261-016-1034-y

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STEP AAG HeroTeaserCollection image/© Tarek / Generated with AI / Stock.adobe.com, ACC 2024 Pediatric and Congenital Heart Disease: Year in Review/© 2024 American College of Cardiology, ACC 2024 Pulmonary Vascular Disease: Year in Review/© 2024 American College of Cardiology, ACC 2024 Valvular Heart Disease: Year in Review/© 2024 American College of Cardiology, ACC 2024 HF and Cardiomyopathies: Year in Review/© 2024 American College of Cardiology, Woman out walking/© Seventyfour / stock.adobe.com (symbolic image with model), Woman checking smartwatch /© saltdium / stock.adobe.com (symbolic image with model), Cardiac catheterization/© Damian / stock.adobe.com

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