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Infection
Published in: Infection 1/2018

Open Access 01-02-2018 | Case Report

Case report: Coxiella burnetii vascular infection and lymphoma in the Netherlands

Authors: Sonja E. van Roeden, Cléa Melenotte, Mirjam H. A. Hermans, Harm A. M. Sinnige, Peet T. G. A. Nooijen, Gilles Audoly, Andy I. M. Hoepelman, Jan Jelrik Oosterheert, Didier Raoult, Peter C. Wever

Published in: Infection | Issue 1/2018

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Abstract

Objectives and design

Non-Hodgkin lymphoma has been linked to infection with Coxiella burnetii, potentially through overproduction of IL-10 during infection with C. burnetii.

Materials and methods

Description of a case report.

Results

We describe a patient with retroperitoneal non-Hodgkin lymphoma and vascular infection with C. burnetii. Immunofluorescence staining and fluorescence in situ hybridization targeting specific C. burnetii 16S rRNA were performed on the retroperitoneal lymphoma tissue sample obtained at diagnosis of NHL. Both were strongly positive for the presence of C. burnetii.

Conclusions

This case provokes questions regarding a potential association between C. burnetii and NHL, and underlines the importance of further exploration of this association.
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Metadata
Title
Case report: Coxiella burnetii vascular infection and lymphoma in the Netherlands
Authors
Sonja E. van Roeden
Cléa Melenotte
Mirjam H. A. Hermans
Harm A. M. Sinnige
Peet T. G. A. Nooijen
Gilles Audoly
Andy I. M. Hoepelman
Jan Jelrik Oosterheert
Didier Raoult
Peter C. Wever
Publication date
01-02-2018
Publisher
Springer Berlin Heidelberg
Published in
Infection / Issue 1/2018
Print ISSN: 0300-8126
Electronic ISSN: 1439-0973
DOI
https://doi.org/10.1007/s15010-017-1061-9

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