Published in:
Open Access
01-12-2017 | Case report
Case report - atypical hemolytic uremic syndrome triggered by influenza B
Authors:
Robin Kobbe, Raphael Schild, Martin Christner, Jun Oh, Sebastian Loos, Markus J. Kemper
Published in:
BMC Nephrology
|
Issue 1/2017
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Abstract
Background
Influenza A infections have been described to cause secondary hemolytic uremic syndrome and to trigger atypical hemolytic uremic syndrome (aHUS) in individuals with an underlying genetic complement dysregulation. To date, influenza B has not been reported to trigger aHUS.
Case presentation
A 6-month-old boy presented with hemolytic uremic syndrome triggered by influenza B infection. Initially the child recovered spontaneously. When he relapsed Eculizumab treatment was initiated, resulting in complete and sustained remission. A pathogenic mutation in membrane cofactor protein (MCP) was detected.
Conclusion
Influenza B is a trigger for aHUS and might be underreported as such. Influenza vaccination may protect patients at risk.