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Published in: BMC Oral Health 1/2023

Open Access 01-12-2023 | Caries | Research

Tooth caries classification with quantitative light-induced fluorescence (QLF) images using convolutional neural network for permanent teeth in vivo

Authors: Eun Young Park, Sungmoon Jeong, Sohee Kang, Jungrae Cho, Ju-Yeon Cho, Eun-Kyong Kim

Published in: BMC Oral Health | Issue 1/2023

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Abstract

Background

Owing to the remarkable advancements of artificial intelligence (AI) applications, AI-based detection of dental caries is continuously improving. We evaluated the efficacy of the detection of dental caries with quantitative light-induced fluorescence (QLF) images using a convolutional neural network (CNN) model.

Methods

Overall, 2814 QLF intraoral images were obtained from 606 participants at a dental clinic using Qraypen C® (QC, AIOBIO, Seoul, Republic of Korea) from October 2020 to October 2022. These images included all the types of permanent teeth of which surfaces were smooth or occlusal. Dataset were randomly assigned to the training (56.0%), validation (14.0%), and test (30.0%) subsets of the dataset for caries classification. Moreover, masked images for teeth area were manually prepared to evaluate the segmentation efficacy. To compare diagnostic performance for caries classification according to the types of teeth, the dataset was further classified into the premolar (1,143 images) and molar (1,441 images) groups. As the CNN model, Xception was applied.

Results

Using the original QLF images, the performance of the classification algorithm was relatively good showing 83.2% of accuracy, 85.6% of precision, and 86.9% of sensitivity. After applying the segmentation process for the tooth area, all the performance indics including 85.6% of accuracy, 88.9% of precision, and 86.9% of sensitivity were improved. However, the performance indices of each type of teeth (both premolar and molar) were similar to those for all teeth.

Conclusion

The application of AI to QLF images for caries classification demonstrated a good performance regardless of teeth type among posterior teeth. Additionally, tooth area segmentation through background elimination from QLF images exhibited a better performance.
Literature
2.
go back to reference Petersen PE, Bourgeois D, Ogawa H, Estupinan-Day S, Ndiaye C. The global burden of oral Diseases and risks to oral health. Bull World Health Organ. 2005;83(9):661–9.PubMedPubMedCentral Petersen PE, Bourgeois D, Ogawa H, Estupinan-Day S, Ndiaye C. The global burden of oral Diseases and risks to oral health. Bull World Health Organ. 2005;83(9):661–9.PubMedPubMedCentral
3.
go back to reference Gil-Montoya JA, de Mello AL, Barrios R, Gonzalez-Moles MA, Bravo M. Oral health in the elderly patient and its impact on general well-being: a nonsystematic review. Clin Interv Aging. 2015;10:461–7.CrossRefPubMedPubMedCentral Gil-Montoya JA, de Mello AL, Barrios R, Gonzalez-Moles MA, Bravo M. Oral health in the elderly patient and its impact on general well-being: a nonsystematic review. Clin Interv Aging. 2015;10:461–7.CrossRefPubMedPubMedCentral
4.
go back to reference Yılmaz H, Keles S. Recent methods for diagnosis of dental caries in dentistry. Meandros Med Dent J. 2018;19:1–8.CrossRef Yılmaz H, Keles S. Recent methods for diagnosis of dental caries in dentistry. Meandros Med Dent J. 2018;19:1–8.CrossRef
5.
go back to reference Aljehani A, Yang L, Shi XQ. In vitro quantification of smooth surface caries with DIAGNOdent and the DIAGNOdent pen. Acta Odontol Scand. 2007;65(1):60–3.CrossRefPubMed Aljehani A, Yang L, Shi XQ. In vitro quantification of smooth surface caries with DIAGNOdent and the DIAGNOdent pen. Acta Odontol Scand. 2007;65(1):60–3.CrossRefPubMed
6.
go back to reference van der Veen MH, de Josselin de Jong E. Application of quantitative light-induced fluorescence for assessing early caries lesions. Monogr Oral Sci. 2000;17:144–62.CrossRefPubMed van der Veen MH, de Josselin de Jong E. Application of quantitative light-induced fluorescence for assessing early caries lesions. Monogr Oral Sci. 2000;17:144–62.CrossRefPubMed
7.
go back to reference Kühnisch J, Heinrich-Weltzien R. Guantitative light-induced fluorescence (GLF)-A literature review. Int J Comput Dent. 2004;7:325–38.PubMed Kühnisch J, Heinrich-Weltzien R. Guantitative light-induced fluorescence (GLF)-A literature review. Int J Comput Dent. 2004;7:325–38.PubMed
8.
go back to reference Alammari MR, Smith PW, de Josselin de Jong E, Higham SM. Quantitative light-induced fluorescence (QLF): a tool for early occlusal dental caries detection and supporting decision making in vivo. J Dent. 2013;41(2):127–32.CrossRefPubMed Alammari MR, Smith PW, de Josselin de Jong E, Higham SM. Quantitative light-induced fluorescence (QLF): a tool for early occlusal dental caries detection and supporting decision making in vivo. J Dent. 2013;41(2):127–32.CrossRefPubMed
9.
go back to reference Esteva A, Kuprel B, Novoa RA, Ko J, Swetter SM, Blau HM, et al. Dermatologist-level classification of Skin cancer with deep neural networks. Nature. 2017;542(7639):115–8.CrossRefPubMedPubMedCentral Esteva A, Kuprel B, Novoa RA, Ko J, Swetter SM, Blau HM, et al. Dermatologist-level classification of Skin cancer with deep neural networks. Nature. 2017;542(7639):115–8.CrossRefPubMedPubMedCentral
10.
go back to reference Lee JH, Kim DH, Jeong SN, Choi SH. Detection and diagnosis of dental caries using a deep learning-based convolutional neural network algorithm. J Dent. 2018;77:106–11.CrossRefPubMed Lee JH, Kim DH, Jeong SN, Choi SH. Detection and diagnosis of dental caries using a deep learning-based convolutional neural network algorithm. J Dent. 2018;77:106–11.CrossRefPubMed
11.
go back to reference Lee JH, Kim DH, Jeong SN, Choi SH. Diagnosis and prediction of periodontally compromised teeth using a deep learning-based convolutional neural network algorithm. J Periodontal Implant Sci. 2018;48(2):114–23.CrossRefPubMedPubMedCentral Lee JH, Kim DH, Jeong SN, Choi SH. Diagnosis and prediction of periodontally compromised teeth using a deep learning-based convolutional neural network algorithm. J Periodontal Implant Sci. 2018;48(2):114–23.CrossRefPubMedPubMedCentral
12.
go back to reference Cantu AG, Gehrung S, Krois J, Chaurasia A, Rossi JG, Gaudin R, et al. Detecting caries lesions of different radiographic extension on bitewings using deep learning. J Dent. 2020;100:103425.CrossRefPubMed Cantu AG, Gehrung S, Krois J, Chaurasia A, Rossi JG, Gaudin R, et al. Detecting caries lesions of different radiographic extension on bitewings using deep learning. J Dent. 2020;100:103425.CrossRefPubMed
13.
14.
go back to reference Srivastava MM, Kumar P, Pradhan L, Varadarajan S. Detection of tooth caries in bitewing radiographs using deep learning. arXiv Preprint arXiv:171107312. 2017. Srivastava MM, Kumar P, Pradhan L, Varadarajan S. Detection of tooth caries in bitewing radiographs using deep learning. arXiv Preprint arXiv:171107312. 2017.
15.
go back to reference Oztekin F, Katar O, Sadak F, Yildirim M, Cakar H, Aydogan M, et al. An Explainable Deep Learning Model to Prediction Dental Caries using panoramic radiograph images. Diagnostics (Basel). 2023;13(2):226.CrossRefPubMed Oztekin F, Katar O, Sadak F, Yildirim M, Cakar H, Aydogan M, et al. An Explainable Deep Learning Model to Prediction Dental Caries using panoramic radiograph images. Diagnostics (Basel). 2023;13(2):226.CrossRefPubMed
16.
go back to reference Prajapati SA, Nagaraj R, Mitra S. Classification of Dental Diseases Using CNN and Transfer Learning. 2017 5th International Symposium on Computational and Business Intelligence (Iscbi). 2017:70 – 4. Prajapati SA, Nagaraj R, Mitra S. Classification of Dental Diseases Using CNN and Transfer Learning. 2017 5th International Symposium on Computational and Business Intelligence (Iscbi). 2017:70 – 4.
17.
go back to reference Zhang X, Liang Y, Li W, Liu C, Gu D, Sun W, et al. Development and evaluation of deep learning for screening dental caries from oral photographs. Oral Dis. 2022;28(1):173–81.CrossRefPubMed Zhang X, Liang Y, Li W, Liu C, Gu D, Sun W, et al. Development and evaluation of deep learning for screening dental caries from oral photographs. Oral Dis. 2022;28(1):173–81.CrossRefPubMed
18.
go back to reference Kuhnisch J, Meyer O, Hesenius M, Hickel R, Gruhn V. Caries Detection on Intraoral images using Artificial Intelligence. J Dent Res. 2022;101(2):158–65.CrossRefPubMed Kuhnisch J, Meyer O, Hesenius M, Hickel R, Gruhn V. Caries Detection on Intraoral images using Artificial Intelligence. J Dent Res. 2022;101(2):158–65.CrossRefPubMed
19.
go back to reference Thanh MTG, Toan NV, Ngoc VTN, Tra NT, Giap CN, Nguyen DM. Deep learning application in Dental Caries Detection using intraoral photos taken by smartphones. Appl Sciences-Basel. 2022;12(11):5504.CrossRef Thanh MTG, Toan NV, Ngoc VTN, Tra NT, Giap CN, Nguyen DM. Deep learning application in Dental Caries Detection using intraoral photos taken by smartphones. Appl Sciences-Basel. 2022;12(11):5504.CrossRef
20.
go back to reference Park EY, Cho H, Kang S, Jeong S, Kim EK. Caries detection with tooth surface segmentation on intraoral photographic images using deep learning. BMC Oral Health. 2022;22(1):573.CrossRefPubMedPubMedCentral Park EY, Cho H, Kang S, Jeong S, Kim EK. Caries detection with tooth surface segmentation on intraoral photographic images using deep learning. BMC Oral Health. 2022;22(1):573.CrossRefPubMedPubMedCentral
21.
go back to reference Casalegno F, Newton T, Daher R, Abdelaziz M, Lodi-Rizzini A, Schurmann F, et al. Caries Detection with Near-Infrared Transillumination using deep learning. J Dent Res. 2019;98(11):1227–33.CrossRefPubMed Casalegno F, Newton T, Daher R, Abdelaziz M, Lodi-Rizzini A, Schurmann F, et al. Caries Detection with Near-Infrared Transillumination using deep learning. J Dent Res. 2019;98(11):1227–33.CrossRefPubMed
22.
go back to reference Schwendicke F, Elhennawy K, Paris S, Friebertshauser P, Krois J. Deep learning for caries lesion detection in near-infrared light transillumination images: a pilot study. J Dent. 2020;92:103260.CrossRefPubMed Schwendicke F, Elhennawy K, Paris S, Friebertshauser P, Krois J. Deep learning for caries lesion detection in near-infrared light transillumination images: a pilot study. J Dent. 2020;92:103260.CrossRefPubMed
23.
go back to reference Imangaliyev S, van der Veen MH, Volgenant CMC, Loos BG, Keijser BJF, Crielaard W, et al. Classification of quantitative light-Induced fluorescence images using convolutional neural network. Artif Neural Networks Mach Learn Pt Ii. 2017;10614:778–9. Imangaliyev S, van der Veen MH, Volgenant CMC, Loos BG, Keijser BJF, Crielaard W, et al. Classification of quantitative light-Induced fluorescence images using convolutional neural network. Artif Neural Networks Mach Learn Pt Ii. 2017;10614:778–9.
24.
go back to reference Rana A, Yauney G, Wong LC, Gupta O, Muftu A, Shah P. Automated segmentation of gingival Diseases from oral images. 2017 IEEE Healthcare Innovations and Point of Care Technologies (HI-POCT). 2017:144–7. Rana A, Yauney G, Wong LC, Gupta O, Muftu A, Shah P. Automated segmentation of gingival Diseases from oral images. 2017 IEEE Healthcare Innovations and Point of Care Technologies (HI-POCT). 2017:144–7.
25.
go back to reference Yauney G, Angelino K, Edlund D, Shah P. Convolutional neural network for combined classification of fluorescent biomarkers and expert annotations using white light images. 2017 IEEE 17th International Conference on Bioinformatics and Bioengineering (BIBE). 2017:303-9. Yauney G, Angelino K, Edlund D, Shah P. Convolutional neural network for combined classification of fluorescent biomarkers and expert annotations using white light images. 2017 IEEE 17th International Conference on Bioinformatics and Bioengineering (BIBE). 2017:303-9.
26.
go back to reference You W, Hao A, Li S, Wang Y, Xia B. Deep learning-based dental plaque detection on primary teeth: a comparison with clinical assessments. BMC Oral Health. 2020;20(1):141.CrossRefPubMedPubMedCentral You W, Hao A, Li S, Wang Y, Xia B. Deep learning-based dental plaque detection on primary teeth: a comparison with clinical assessments. BMC Oral Health. 2020;20(1):141.CrossRefPubMedPubMedCentral
27.
go back to reference Bossuyt PM, Reitsma JB, Bruns DE, Gatsonis CA, Glasziou PP, Irwig L, et al. STARD 2015: an updated list of essential items for reporting diagnostic accuracy studies. BMJ. 2015;351:h5527.CrossRefPubMedPubMedCentral Bossuyt PM, Reitsma JB, Bruns DE, Gatsonis CA, Glasziou PP, Irwig L, et al. STARD 2015: an updated list of essential items for reporting diagnostic accuracy studies. BMJ. 2015;351:h5527.CrossRefPubMedPubMedCentral
28.
go back to reference Ismail AI, Sohn W, Tellez M, Amaya A, Sen A, Hasson H, et al. The International Caries Detection and Assessment System (ICDAS): an integrated system for measuring dental caries. Community Dent Oral Epidemiol. 2007;35(3):170–8.CrossRefPubMed Ismail AI, Sohn W, Tellez M, Amaya A, Sen A, Hasson H, et al. The International Caries Detection and Assessment System (ICDAS): an integrated system for measuring dental caries. Community Dent Oral Epidemiol. 2007;35(3):170–8.CrossRefPubMed
29.
go back to reference Wu X, Liu R, Yang H, Chen Z. An xception based convolutional neural network for scene image classification with transfer learning. 2020 2nd International Conference on Information Technology and Computer Application (ITCA), Guangzhou, China. 2020:262-7. Wu X, Liu R, Yang H, Chen Z. An xception based convolutional neural network for scene image classification with transfer learning. 2020 2nd International Conference on Information Technology and Computer Application (ITCA), Guangzhou, China. 2020:262-7.
30.
go back to reference Chollet F, Xception. Deep Learning with Depthwise Separable Convolutions. 30th Ieee Conference on Computer Vision and Pattern Recognition (Cvpr 2017). 2017:1800-7. Chollet F, Xception. Deep Learning with Depthwise Separable Convolutions. 30th Ieee Conference on Computer Vision and Pattern Recognition (Cvpr 2017). 2017:1800-7.
31.
go back to reference Erten H, Uctasli MB, Akarslan ZZ, Uzun O, Baspinar E. The assessment of unaided visual examination, intraoral camera and operating microscope for the detection of occlusal caries lesions. Oper Dent. 2005;30(2):190–4.PubMed Erten H, Uctasli MB, Akarslan ZZ, Uzun O, Baspinar E. The assessment of unaided visual examination, intraoral camera and operating microscope for the detection of occlusal caries lesions. Oper Dent. 2005;30(2):190–4.PubMed
32.
go back to reference Forgie AH, Pitts NB. The assessment of an intra-oral video camera as an aid to occlusal caries detection. Int Dent J. 2003;53(1):3–6.CrossRefPubMed Forgie AH, Pitts NB. The assessment of an intra-oral video camera as an aid to occlusal caries detection. Int Dent J. 2003;53(1):3–6.CrossRefPubMed
33.
go back to reference Pentapati KC, Siddiq H. Clinical applications of intraoral camera to increase patient compliance - current perspectives. Clin Cosmet Investig Dent. 2019;11:267–78.CrossRefPubMedPubMedCentral Pentapati KC, Siddiq H. Clinical applications of intraoral camera to increase patient compliance - current perspectives. Clin Cosmet Investig Dent. 2019;11:267–78.CrossRefPubMedPubMedCentral
34.
go back to reference Snyder T. The intraoral camera: a popular computerized tool. J Am Dent Assoc. 1995;126:177–8.CrossRef Snyder T. The intraoral camera: a popular computerized tool. J Am Dent Assoc. 1995;126:177–8.CrossRef
35.
go back to reference van der Veen MH, Thomas RZ, Huysmans MC, de Soet JJ. Red autofluorescence of dental plaque bacteria. Caries Res. 2006;40(6):542–5.CrossRefPubMed van der Veen MH, Thomas RZ, Huysmans MC, de Soet JJ. Red autofluorescence of dental plaque bacteria. Caries Res. 2006;40(6):542–5.CrossRefPubMed
36.
go back to reference Han SY, Kim BR, Ko HY, Kwon HK, Kim BI. Assessing the use of quantitative light-induced fluorescence-digital as a clinical plaque assessment. Photodiagnosis Photodyn Ther. 2016;13:34–9.CrossRefPubMed Han SY, Kim BR, Ko HY, Kwon HK, Kim BI. Assessing the use of quantitative light-induced fluorescence-digital as a clinical plaque assessment. Photodiagnosis Photodyn Ther. 2016;13:34–9.CrossRefPubMed
37.
go back to reference Kim YS, Lee ES, Kwon HK, Kim BI. Monitoring the maturation process of a dental microcosm biofilm using the quantitative light-induced fluorescence-digital (QLF-D). J Dent. 2014;42(6):691–6.CrossRefPubMed Kim YS, Lee ES, Kwon HK, Kim BI. Monitoring the maturation process of a dental microcosm biofilm using the quantitative light-induced fluorescence-digital (QLF-D). J Dent. 2014;42(6):691–6.CrossRefPubMed
38.
go back to reference Park S, Lee H, Kim S, Lee E, Jong E. de Josselin de Jong E, Comparison of fluorescence loss measurements among various generations of QLF devices. J Kor Dent Assoc. 2018;56(1):8–16. Park S, Lee H, Kim S, Lee E, Jong E. de Josselin de Jong E, Comparison of fluorescence loss measurements among various generations of QLF devices. J Kor Dent Assoc. 2018;56(1):8–16.
39.
go back to reference Wang C, Qin HT, Lai GY, Zheng G, Xiang HZ, Wang J, et al. Automated classification of dual channel dental imaging of auto-fluorescence and white lightby convolutional neural networks. J Innovative Opt Health Sci. 2020;13(4):2050014.CrossRef Wang C, Qin HT, Lai GY, Zheng G, Xiang HZ, Wang J, et al. Automated classification of dual channel dental imaging of auto-fluorescence and white lightby convolutional neural networks. J Innovative Opt Health Sci. 2020;13(4):2050014.CrossRef
40.
go back to reference Wang C, Zhang R, Wei X, Wang L, Xu W, Yao Q. Machine learning-based automatic identification and diagnosis of dental caries and calculus using hyperspectral fluorescence imaging. Photodiagnosis Photodyn Ther. 2023;41:103217.CrossRefPubMed Wang C, Zhang R, Wei X, Wang L, Xu W, Yao Q. Machine learning-based automatic identification and diagnosis of dental caries and calculus using hyperspectral fluorescence imaging. Photodiagnosis Photodyn Ther. 2023;41:103217.CrossRefPubMed
Metadata
Title
Tooth caries classification with quantitative light-induced fluorescence (QLF) images using convolutional neural network for permanent teeth in vivo
Authors
Eun Young Park
Sungmoon Jeong
Sohee Kang
Jungrae Cho
Ju-Yeon Cho
Eun-Kyong Kim
Publication date
01-12-2023
Publisher
BioMed Central
Published in
BMC Oral Health / Issue 1/2023
Electronic ISSN: 1472-6831
DOI
https://doi.org/10.1186/s12903-023-03669-6

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