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Published in: Intensive Care Medicine 12/2021

Open Access 01-12-2021 | Care | Guidelines

Transfusion strategies in bleeding critically ill adults: a clinical practice guideline from the European Society of Intensive Care Medicine

Authors: Alexander P. J. Vlaar, Joanna C. Dionne, Sanne de Bruin, Marije Wijnberge, S. Jorinde Raasveld, Frank E. H. P. van Baarle, Massimo Antonelli, Cecile Aubron, Jacques Duranteau, Nicole P. Juffermans, Jens Meier, Gavin J. Murphy, Riccardo Abbasciano, Marcella C. A. Müller, Marcus Lance, Nathan D. Nielsen, Herbert Schöchl, Beverley J. Hunt, Maurizio Cecconi, Simon Oczkowski

Published in: Intensive Care Medicine | Issue 12/2021

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Abstract

Purpose

To develop evidence-based clinical practice recommendations regarding transfusion practices and transfusion in bleeding critically ill adults.

Methods

A taskforce involving 15 international experts and 2 methodologists used the GRADE approach to guideline development. The taskforce addressed three main topics: transfusion support in massively and non-massively bleeding critically ill patients (transfusion ratios, blood products, and point of care testing) and the use of tranexamic acid. The panel developed and answered structured guideline questions using population, intervention, comparison, and outcomes (PICO) format.

Results

The taskforce generated 26 clinical practice recommendations (2 strong recommendations, 13 conditional recommendations, 11 no recommendation), and identified 10 PICOs with insufficient evidence to make a recommendation.

Conclusions

This clinical practice guideline provides evidence-based recommendations for the management of massively and non-massively bleeding critically ill adult patients and identifies areas where further research is needed.
Appendix
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Metadata
Title
Transfusion strategies in bleeding critically ill adults: a clinical practice guideline from the European Society of Intensive Care Medicine
Authors
Alexander P. J. Vlaar
Joanna C. Dionne
Sanne de Bruin
Marije Wijnberge
S. Jorinde Raasveld
Frank E. H. P. van Baarle
Massimo Antonelli
Cecile Aubron
Jacques Duranteau
Nicole P. Juffermans
Jens Meier
Gavin J. Murphy
Riccardo Abbasciano
Marcella C. A. Müller
Marcus Lance
Nathan D. Nielsen
Herbert Schöchl
Beverley J. Hunt
Maurizio Cecconi
Simon Oczkowski
Publication date
01-12-2021
Publisher
Springer Berlin Heidelberg
Published in
Intensive Care Medicine / Issue 12/2021
Print ISSN: 0342-4642
Electronic ISSN: 1432-1238
DOI
https://doi.org/10.1007/s00134-021-06531-x

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