Skip to main content
Top
Published in: BMC Geriatrics 1/2020

Open Access 01-12-2020 | Care | Research article

Improving medication appropriateness in nursing homes via structured interprofessional medication-review supported by health information technology: a non-randomized controlled study

Authors: Johanna Katharina Dellinger, Stefan Pitzer, Dagmar Schaffler-Schaden, Maria Magdalena Schreier, Laura Sandre Fährmann, Georg Hempel, Rudolf Likar, Jürgen Osterbrink, Maria Flamm

Published in: BMC Geriatrics | Issue 1/2020

Login to get access

Abstract

Background

In nursing home residents (NHRs), polypharmacy is widespread, accompanied by elevated risks of medication related complications. Managing medication in NHRs is a priority, but prone to several challenges, including interprofessional cooperation. Against this background, we implemented and tested an interprofessional intervention aimed to improve medication appropriateness for NHRs.

Methods

A non-randomized controlled study (SiMbA; “Sicherheit der Medikamentherapie bei AltenheimbewohnerInnen”, Safety of medication therapy in NHRs) was conducted in six nursing homes in Austria (2016–2018). Educational training, introduction of tailored health information technology (HIT) and a therapy check process were combined in an intervention aimed at healthcare professionals. Medication appropriateness was assessed using the Medication Appropriateness Index (MAI). Data was collected before (t0), during (t1, month 12) and after (t2, month 18) intervention via self-administered assessments and electronic health records.

Results

We included 6 NHs, 17 GPs (52.94% female) and 240 NHRs (68.75% female; mean age 85.0). Data of 159 NHRs could be included in the analysis. Mean MAI-change was − 3.35 (IG) vs. − 1.45 (CG). In the subgroup of NHRs with mean MAI ≥23, MAI-change was − 10.31 (IG) vs. −3.52 (CG). The intervention was a significant predictor of improvement in MAI when controlled for in a multivariable regression model.

Conclusions

Improvement of medication appropriateness was clearest in residents with inappropriate baseline MAI-scores. This improvement was independent of variances in certain covariates between the intervention and the control group. We conclude that our intervention is a feasible approach to improve NHRs’ medication appropriateness.

Trial registration

DRKS Data Management, ID: DRKS00012246. Registered 16.05.2017 – Retrospectively registered.
Literature
1.
go back to reference Alldred DP, Kennedy MC, Hughes C, Chen TF, Miller P. Interventions to optimise prescribing for older people in care homes. Cochrane Database Syst Rev. 2016;2:CD009095.PubMed Alldred DP, Kennedy MC, Hughes C, Chen TF, Miller P. Interventions to optimise prescribing for older people in care homes. Cochrane Database Syst Rev. 2016;2:CD009095.PubMed
2.
go back to reference Bokhof B, Junius-Walker U. Reducing Polypharmacy from the perspectives of general practitioners and older patients: a synthesis of qualitative studies. Drugs Aging. 2016;33(4):249–66.CrossRefPubMed Bokhof B, Junius-Walker U. Reducing Polypharmacy from the perspectives of general practitioners and older patients: a synthesis of qualitative studies. Drugs Aging. 2016;33(4):249–66.CrossRefPubMed
3.
go back to reference Corsonello A, Pedone C, Incalzi RA. Age-related pharmacokinetic and pharmacodynamic changes and related risk of adverse drug reactions. Curr Med Chem. 2010;17(6):571–84.CrossRefPubMed Corsonello A, Pedone C, Incalzi RA. Age-related pharmacokinetic and pharmacodynamic changes and related risk of adverse drug reactions. Curr Med Chem. 2010;17(6):571–84.CrossRefPubMed
4.
go back to reference Morin L, Laroche ML, Texier G, Johnell K. Prevalence of Potentially Inappropriate Medication Use in Older Adults Living in Nursing Homes: A Systematic Review. J Am Med Dir Assoc. 2016;17(9):862 e1–9.CrossRefPubMed Morin L, Laroche ML, Texier G, Johnell K. Prevalence of Potentially Inappropriate Medication Use in Older Adults Living in Nursing Homes: A Systematic Review. J Am Med Dir Assoc. 2016;17(9):862 e1–9.CrossRefPubMed
5.
go back to reference Frazier SC. Health outcomes and polypharmacy in elderly individuals: an integrated literature review. J Gerontol Nurs. 2005;31(9):4–11.CrossRefPubMed Frazier SC. Health outcomes and polypharmacy in elderly individuals: an integrated literature review. J Gerontol Nurs. 2005;31(9):4–11.CrossRefPubMed
6.
go back to reference Midao L, Giardini A, Menditto E, Kardas P, Costa E. Polypharmacy prevalence among older adults based on the survey of health, ageing and retirement in Europe. Arch Gerontol Geriatr. 2018;78:213–20.CrossRefPubMed Midao L, Giardini A, Menditto E, Kardas P, Costa E. Polypharmacy prevalence among older adults based on the survey of health, ageing and retirement in Europe. Arch Gerontol Geriatr. 2018;78:213–20.CrossRefPubMed
7.
go back to reference Alzner R, Bauer U, Pitzer S, Schreier MM, Osterbrink J, Iglseder B. Polypharmacy, potentially inappropriate medication and cognitive status in Austrian nursing home residents: results from the OSiA study. Wien Med Wochenschr. 2016;166(5–6):161–5.CrossRefPubMed Alzner R, Bauer U, Pitzer S, Schreier MM, Osterbrink J, Iglseder B. Polypharmacy, potentially inappropriate medication and cognitive status in Austrian nursing home residents: results from the OSiA study. Wien Med Wochenschr. 2016;166(5–6):161–5.CrossRefPubMed
8.
go back to reference Koper D, Kamenski G, Flamm M, Bohmdorfer B, Sonnichsen A. Frequency of medication errors in primary care patients with polypharmacy. Fam Pract. 2013;30(3):313–9.CrossRefPubMed Koper D, Kamenski G, Flamm M, Bohmdorfer B, Sonnichsen A. Frequency of medication errors in primary care patients with polypharmacy. Fam Pract. 2013;30(3):313–9.CrossRefPubMed
9.
go back to reference Knopf H, Grams D. Medication use of adults in Germany: results of the German health interview and examination survey for adults (DEGS1). Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz. 2013;56(5–6):868–77.CrossRefPubMed Knopf H, Grams D. Medication use of adults in Germany: results of the German health interview and examination survey for adults (DEGS1). Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz. 2013;56(5–6):868–77.CrossRefPubMed
10.
go back to reference Maher RL, Hanlon J, Hajjar ER. Clinical consequences of polypharmacy in elderly. Expert Opin Drug Saf. 2014;13(1):57–65.CrossRefPubMed Maher RL, Hanlon J, Hajjar ER. Clinical consequences of polypharmacy in elderly. Expert Opin Drug Saf. 2014;13(1):57–65.CrossRefPubMed
11.
go back to reference Storms H, Marquet K, Aertgeerts B, Claes N. Prevalence of inappropriate medication use in residential long-term care facilities for the elderly: a systematic review. Eur J Gen Pract. 2017;23(1):69–77.CrossRefPubMedPubMedCentral Storms H, Marquet K, Aertgeerts B, Claes N. Prevalence of inappropriate medication use in residential long-term care facilities for the elderly: a systematic review. Eur J Gen Pract. 2017;23(1):69–77.CrossRefPubMedPubMedCentral
12.
go back to reference Mann E, Haastert B, Bohmdorfer B, Fruhwald T, Iglseder B, Roller-Wirnsberger R, et al. Prevalence and associations of potentially inappropriate prescriptions in Austrian nursing home residents: secondary analysis of a cross-sectional study. Wien Klin Wochenschr. 2013;125(7–8):180–8.CrossRefPubMed Mann E, Haastert B, Bohmdorfer B, Fruhwald T, Iglseder B, Roller-Wirnsberger R, et al. Prevalence and associations of potentially inappropriate prescriptions in Austrian nursing home residents: secondary analysis of a cross-sectional study. Wien Klin Wochenschr. 2013;125(7–8):180–8.CrossRefPubMed
13.
go back to reference Ferrah N, Lovell JJ, Ibrahim JE. Systematic review of the prevalence of medication errors resulting in hospitalization and death of nursing home residents. J Am Geriatr Soc. 2017;65(2):433–42.CrossRefPubMed Ferrah N, Lovell JJ, Ibrahim JE. Systematic review of the prevalence of medication errors resulting in hospitalization and death of nursing home residents. J Am Geriatr Soc. 2017;65(2):433–42.CrossRefPubMed
14.
go back to reference Barr N, Vania D, Randall G, Mulvale G. Impact of information and communication technology on interprofessional collaboration for chronic disease management: a systematic review. J Health Serv Res Policy. 2017;22(4):250–7.CrossRefPubMed Barr N, Vania D, Randall G, Mulvale G. Impact of information and communication technology on interprofessional collaboration for chronic disease management: a systematic review. J Health Serv Res Policy. 2017;22(4):250–7.CrossRefPubMed
15.
go back to reference Tariq A, Georgiou A, Westbrook J. Medication errors in residential aged care facilities: a distributed cognition analysis of the information exchange process. Int J Med Inform. 2013;82(5):299–312.CrossRefPubMed Tariq A, Georgiou A, Westbrook J. Medication errors in residential aged care facilities: a distributed cognition analysis of the information exchange process. Int J Med Inform. 2013;82(5):299–312.CrossRefPubMed
16.
go back to reference McKibbon KA, Lokker C, Handler SM, Dolovich LR, Holbrook AM, O'Reilly D, et al. The effectiveness of integrated health information technologies across the phases of medication management: a systematic review of randomized controlled trials. J Am Med Informatics Assoc. 2012;19(1):22–30.CrossRef McKibbon KA, Lokker C, Handler SM, Dolovich LR, Holbrook AM, O'Reilly D, et al. The effectiveness of integrated health information technologies across the phases of medication management: a systematic review of randomized controlled trials. J Am Med Informatics Assoc. 2012;19(1):22–30.CrossRef
17.
go back to reference McKibbon KA, Lokker C, Handler SM, Dolovich LR, Holbrook AM, O'Reilly D, et al. Enabling medication management through health information technology (health IT). Evid Rep Technol Assess. 2011;201:1–951. McKibbon KA, Lokker C, Handler SM, Dolovich LR, Holbrook AM, O'Reilly D, et al. Enabling medication management through health information technology (health IT). Evid Rep Technol Assess. 2011;201:1–951.
18.
go back to reference Schaffler-Schaden D, Pitzer S, Schreier M, Dellinger J, Brandauer-Stickler B, Lainer M, et al. Improving medication appropriateness in nursing home residents by enhancing interprofessional cooperation: a study protocol. J Interprof Care. 2018;32(4):517–20.CrossRefPubMed Schaffler-Schaden D, Pitzer S, Schreier M, Dellinger J, Brandauer-Stickler B, Lainer M, et al. Improving medication appropriateness in nursing home residents by enhancing interprofessional cooperation: a study protocol. J Interprof Care. 2018;32(4):517–20.CrossRefPubMed
20.
go back to reference (ABDA) BDA. Grundsatzpapier zur Medikationsanalyse und zum Medikationsmanagement. Überblick über die verschiedenen Konzepte zur Medikationsanalyse und zum Medikationsmanagement als apothekerliche Tätigkeit: Bundesvereinigung Deutscher Apothekerverbände (ABDA); 2014. Available from: https://www.abda.de/uploads/media/Grundsatzpapier.pdf. [Online 01.08.2019]. (ABDA) BDA. Grundsatzpapier zur Medikationsanalyse und zum Medikationsmanagement. Überblick über die verschiedenen Konzepte zur Medikationsanalyse und zum Medikationsmanagement als apothekerliche Tätigkeit: Bundesvereinigung Deutscher Apothekerverbände (ABDA); 2014. Available from: https://​www.​abda.​de/​uploads/​media/​Grundsatzpapier.​pdf. [Online 01.08.2019].
21.
go back to reference Hanlon JT, Schmader KE, Samsa GP, Weinberger M, Uttech KM, Lewis IK, et al. A method for assessing drug therapy appropriateness. J Clin Epidemiol. 1992;45(10):1045–51.CrossRefPubMed Hanlon JT, Schmader KE, Samsa GP, Weinberger M, Uttech KM, Lewis IK, et al. A method for assessing drug therapy appropriateness. J Clin Epidemiol. 1992;45(10):1045–51.CrossRefPubMed
22.
go back to reference Kohler L, Weyerer S, Schaufele M. Proxy screening tools improve the recognition of dementia in old-age homes: results of a validation study. Age Ageing. 2007;36(5):549–54.CrossRefPubMed Kohler L, Weyerer S, Schaufele M. Proxy screening tools improve the recognition of dementia in old-age homes: results of a validation study. Age Ageing. 2007;36(5):549–54.CrossRefPubMed
23.
go back to reference Katz S, Ford AB, Moskowitz RW, Jackson BA, Jaffe MW. Studies of illness in the aged. The index of Adl: a standardized measure of biological and psychosocial function. JAMA. 1963;185:914–9.CrossRefPubMed Katz S, Ford AB, Moskowitz RW, Jackson BA, Jaffe MW. Studies of illness in the aged. The index of Adl: a standardized measure of biological and psychosocial function. JAMA. 1963;185:914–9.CrossRefPubMed
25.
go back to reference Charlson ME, Pompei P, Ales KL, MacKenzie CR. A new method of classifying prognostic comorbidity in longitudinal studies: development and validation. J Chronic Dis. 1987;40(5):373–83.CrossRefPubMed Charlson ME, Pompei P, Ales KL, MacKenzie CR. A new method of classifying prognostic comorbidity in longitudinal studies: development and validation. J Chronic Dis. 1987;40(5):373–83.CrossRefPubMed
26.
go back to reference Samsa GP, Hanlon JT, Schmader KE, Weinberger M, Clipp EC, Uttech KM, et al. A summated score for the medication appropriateness index: development and assessment of clinimetric properties including content validity. J Clin Epidemiol. 1994;47(8):891–6.CrossRefPubMed Samsa GP, Hanlon JT, Schmader KE, Weinberger M, Clipp EC, Uttech KM, et al. A summated score for the medication appropriateness index: development and assessment of clinimetric properties including content validity. J Clin Epidemiol. 1994;47(8):891–6.CrossRefPubMed
27.
go back to reference Rose O, Mennemann H, John C, Lautenschlager M, Mertens-Keller D, Richling K, et al. Priority setting and influential factors on acceptance of pharmaceutical recommendations in collaborative medication reviews in an ambulatory care setting - analysis of a cluster randomized controlled trial (WestGem-study). PLoS One. 2016;11(6):e0156304.CrossRefPubMedPubMedCentral Rose O, Mennemann H, John C, Lautenschlager M, Mertens-Keller D, Richling K, et al. Priority setting and influential factors on acceptance of pharmaceutical recommendations in collaborative medication reviews in an ambulatory care setting - analysis of a cluster randomized controlled trial (WestGem-study). PLoS One. 2016;11(6):e0156304.CrossRefPubMedPubMedCentral
28.
go back to reference Norman GR, Sloan JA, Wyrwich KW. Interpretation of changes in health-related quality of life: the remarkable universality of half a standard deviation. Med Care. 2003;41(5):582–92.PubMed Norman GR, Sloan JA, Wyrwich KW. Interpretation of changes in health-related quality of life: the remarkable universality of half a standard deviation. Med Care. 2003;41(5):582–92.PubMed
29.
go back to reference Crotty M, Halbert J, Rowett D, Giles L, Birks R, Williams H, et al. An outreach geriatric medication advisory service in residential aged care: a randomised controlled trial of case conferencing. Age Ageing. 2004;33(6):612–7.CrossRefPubMed Crotty M, Halbert J, Rowett D, Giles L, Birks R, Williams H, et al. An outreach geriatric medication advisory service in residential aged care: a randomised controlled trial of case conferencing. Age Ageing. 2004;33(6):612–7.CrossRefPubMed
30.
go back to reference Hanlon JT, Schmader KE. The medication appropriateness index at 20: where it started, where it has been, and where it may be going. Drugs Aging. 2013;30(11):893–900.CrossRefPubMed Hanlon JT, Schmader KE. The medication appropriateness index at 20: where it started, where it has been, and where it may be going. Drugs Aging. 2013;30(11):893–900.CrossRefPubMed
31.
go back to reference Morris SB, DeShon RP. Combining effect size estimates in meta-analysis with repeated measures and independent-groups designs. Psychol Methods. 2002;7(1):105–25.CrossRefPubMed Morris SB, DeShon RP. Combining effect size estimates in meta-analysis with repeated measures and independent-groups designs. Psychol Methods. 2002;7(1):105–25.CrossRefPubMed
32.
go back to reference Morris SB. Estimating effect sizes from pretest-posttest-control group designs. Organ Res Methods. 2007;11(2):364–86.CrossRef Morris SB. Estimating effect sizes from pretest-posttest-control group designs. Organ Res Methods. 2007;11(2):364–86.CrossRef
33.
go back to reference Muth C, Uhlmann L, Haefeli WE, Rochon J, van den Akker M, Perera R, et al. Effectiveness of a complex intervention on Prioritising multimedication in multimorbidity (PRIMUM) in primary care: results of a pragmatic cluster randomised controlled trial. BMJ Open. 2018;8(2):e017740.CrossRefPubMedPubMedCentral Muth C, Uhlmann L, Haefeli WE, Rochon J, van den Akker M, Perera R, et al. Effectiveness of a complex intervention on Prioritising multimedication in multimorbidity (PRIMUM) in primary care: results of a pragmatic cluster randomised controlled trial. BMJ Open. 2018;8(2):e017740.CrossRefPubMedPubMedCentral
34.
go back to reference Patterson SM, Cadogan CA, Kerse N, Cardwell CR, Bradley MC, Ryan C, et al. Interventions to improve the appropriate use of polypharmacy for older people. Cochrane Database Syst Rev. 2014;10:CD008165. Patterson SM, Cadogan CA, Kerse N, Cardwell CR, Bradley MC, Ryan C, et al. Interventions to improve the appropriate use of polypharmacy for older people. Cochrane Database Syst Rev. 2014;10:CD008165.
35.
go back to reference Nothelle SK, Sharma R, Oakes AH, Jackson M, Segal JB. Determinants of Potentially Inappropriate Medication Use in Long-Term and Acute Care Settings: A Systematic Review. J Am Med Dir Assoc. 2017;18(9):806 e1- e17.CrossRefPubMedPubMedCentral Nothelle SK, Sharma R, Oakes AH, Jackson M, Segal JB. Determinants of Potentially Inappropriate Medication Use in Long-Term and Acute Care Settings: A Systematic Review. J Am Med Dir Assoc. 2017;18(9):806 e1- e17.CrossRefPubMedPubMedCentral
Metadata
Title
Improving medication appropriateness in nursing homes via structured interprofessional medication-review supported by health information technology: a non-randomized controlled study
Authors
Johanna Katharina Dellinger
Stefan Pitzer
Dagmar Schaffler-Schaden
Maria Magdalena Schreier
Laura Sandre Fährmann
Georg Hempel
Rudolf Likar
Jürgen Osterbrink
Maria Flamm
Publication date
01-12-2020
Publisher
BioMed Central
Keyword
Care
Published in
BMC Geriatrics / Issue 1/2020
Electronic ISSN: 1471-2318
DOI
https://doi.org/10.1186/s12877-020-01895-z

Other articles of this Issue 1/2020

BMC Geriatrics 1/2020 Go to the issue
Live Webinar | 27-06-2024 | 18:00 (CEST)

Keynote webinar | Spotlight on medication adherence

Live: Thursday 27th June 2024, 18:00-19:30 (CEST)

WHO estimates that half of all patients worldwide are non-adherent to their prescribed medication. The consequences of poor adherence can be catastrophic, on both the individual and population level.

Join our expert panel to discover why you need to understand the drivers of non-adherence in your patients, and how you can optimize medication adherence in your clinics to drastically improve patient outcomes.

Prof. Kevin Dolgin
Prof. Florian Limbourg
Prof. Anoop Chauhan
Developed by: Springer Medicine
Obesity Clinical Trial Summary

At a glance: The STEP trials

A round-up of the STEP phase 3 clinical trials evaluating semaglutide for weight loss in people with overweight or obesity.

Developed by: Springer Medicine

Highlights from the ACC 2024 Congress

Year in Review: Pediatric cardiology

Watch Dr. Anne Marie Valente present the last year's highlights in pediatric and congenital heart disease in the official ACC.24 Year in Review session.

Year in Review: Pulmonary vascular disease

The last year's highlights in pulmonary vascular disease are presented by Dr. Jane Leopold in this official video from ACC.24.

Year in Review: Valvular heart disease

Watch Prof. William Zoghbi present the last year's highlights in valvular heart disease from the official ACC.24 Year in Review session.

Year in Review: Heart failure and cardiomyopathies

Watch this official video from ACC.24. Dr. Biykem Bozkurt discusses last year's major advances in heart failure and cardiomyopathies.