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Published in: BMC Nephrology 1/2022

Open Access 01-12-2022 | Care | Study protocol

A study protocol for improving the delivery of acute kidney replacement therapy (KRT) to critically ill patients in Alberta – DIALYZING WISELY

Authors: Dawn Opgenorth, Sean M. Bagshaw, Vincent Lau, Michelle M. Graham, Nancy Fraser, Scott Klarenbach, Louise Morrin, Colleen Norris, Neesh Pannu, Selvi Sinnadurai, Shelley Valaire, Xiaoming Wang, Oleksa G. Rewa

Published in: BMC Nephrology | Issue 1/2022

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Abstract

Background

Acute kidney replacement therapy (KRT) is delivered to acutely ill patients to support organ function and life in the Intensive Care Unit (ICU). Implementing standardized acute KRT pathways can ensure its safe and effective management. At present, there is no standardized approach to the management of acute KRT in Alberta ICUs.

Methods

Dialyzing Wisely is a registry embedded, stepped-wedge, interrupted time-series evaluation of the implementation of a standardized, stakeholder-informed, and evidence-based acute KRT pathway into Alberta ICUs. The acute KRT pathway will consist of two distinct phases. First, we will implement routine monitoring of evidence-informed key performance indicators (KPIs) of acute KRT. Second, we will provide prescriber and program reports for acute KRT initiation patterns. After the implementation of both phases of the pathway, we will evaluate acute KRT performance quarterly and implement a customized suite of interventions aimed at improving performance. We will compare this with baseline and evaluate iterative post implementation effects of the care pathway.

Discussion

Dialyzing Wisely will implement, monitor, and report a suite of KPIs of acute KRT, coupled with a care pathway that will transform the quality of acute KRT across ICUs in Alberta. This program will provide a framework for scaling evidence-informed approaches to monitoring and management of acute KRT in other jurisdictions. We anticipate improvements in acute KRT performance, decreased healthcare system costs and improved patient quality of life by decreasing patient dependence on maintenance dialysis.

Trial registration

Clinicaltrials.​gov, NCT05186636. Registered 11, January, 2022.
Appendix
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Metadata
Title
A study protocol for improving the delivery of acute kidney replacement therapy (KRT) to critically ill patients in Alberta – DIALYZING WISELY
Authors
Dawn Opgenorth
Sean M. Bagshaw
Vincent Lau
Michelle M. Graham
Nancy Fraser
Scott Klarenbach
Louise Morrin
Colleen Norris
Neesh Pannu
Selvi Sinnadurai
Shelley Valaire
Xiaoming Wang
Oleksa G. Rewa
Publication date
01-12-2022
Publisher
BioMed Central
Keyword
Care
Published in
BMC Nephrology / Issue 1/2022
Electronic ISSN: 1471-2369
DOI
https://doi.org/10.1186/s12882-022-02990-6

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