Skip to main content
Top
Published in: Current Heart Failure Reports 2/2014

01-06-2014 | Pathophysiology: Neuroendocrine, Vascular, and Metabolic Factors (SD Katz, Section Editor)

Cardiovascular Responses to Heat Stress in Chronic Heart Failure

Authors: Jian Cui, Lawrence I. Sinoway

Published in: Current Heart Failure Reports | Issue 2/2014

Login to get access

Abstract

Clinical reports have suggested that patients with heart diseases may be particularly vulnerable to heat injury. This review examines the effects of heat stress on cardiovascular and autonomic functions in patients with chronic heart failure (CHF). Laboratory investigations have shown that cutaneous vasodilator responses to heating are impaired in patients, whereas activation of skin sympathetic nerve activation is not attenuated in CHF as compared to controls. Attenuated cutaneous vasodilation may increase the risk of a heat related illness when CHF subjects are exposed to hyperthermic conditions.
Literature
1.
go back to reference Semenza JC, Rubin CH, Falter KH, Selanikio JD, Flanders WD, Howe HL, et al. Heat-related deaths during the July 1995 heat wave in Chicago. N Engl J Med. 1996;335:84–90.PubMedCrossRef Semenza JC, Rubin CH, Falter KH, Selanikio JD, Flanders WD, Howe HL, et al. Heat-related deaths during the July 1995 heat wave in Chicago. N Engl J Med. 1996;335:84–90.PubMedCrossRef
2.
go back to reference Semenza JC, McCullough JE, Flanders WD, McGeehin MA, Lumpkin JR. Excess hospital admissions during the July 1995 heat wave in Chicago. Am J Prev Med. 1999;16:269–77.PubMedCrossRef Semenza JC, McCullough JE, Flanders WD, McGeehin MA, Lumpkin JR. Excess hospital admissions during the July 1995 heat wave in Chicago. Am J Prev Med. 1999;16:269–77.PubMedCrossRef
3.
go back to reference Kovats RS, Johnson H, Griffith C. Mortality in southern England during the 2003 heat wave by place of death. Health Stat Q. 2006;29:6–8.PubMed Kovats RS, Johnson H, Griffith C. Mortality in southern England during the 2003 heat wave by place of death. Health Stat Q. 2006;29:6–8.PubMed
4.
go back to reference Fouillet A, Rey G, Laurent F, Pavillon G, Bellec S, Guihenneuc-Jouyaux C, et al. Excess mortality related to the August 2003 heat wave in France. Int Arch Occup Environ Health. 2006;80:16–24.PubMedCentralPubMedCrossRef Fouillet A, Rey G, Laurent F, Pavillon G, Bellec S, Guihenneuc-Jouyaux C, et al. Excess mortality related to the August 2003 heat wave in France. Int Arch Occup Environ Health. 2006;80:16–24.PubMedCentralPubMedCrossRef
5.
go back to reference Canoui-Poitrine F, Cadot E, Spira A. Excess deaths during the August 2003 heat wave in Paris, France. Rev Epidemiol Sante Publique. 2006;54:127–35.PubMedCrossRef Canoui-Poitrine F, Cadot E, Spira A. Excess deaths during the August 2003 heat wave in Paris, France. Rev Epidemiol Sante Publique. 2006;54:127–35.PubMedCrossRef
6.
go back to reference Knowlton K, Rotkin-Ellman M, King G, Margolis HG, Smith D, Solomon G, et al. The 2006 California heat wave: impacts on hospitalizations and emergency department visits. Environ Health Perspect. 2009;117:61–7.PubMedCentralPubMed Knowlton K, Rotkin-Ellman M, King G, Margolis HG, Smith D, Solomon G, et al. The 2006 California heat wave: impacts on hospitalizations and emergency department visits. Environ Health Perspect. 2009;117:61–7.PubMedCentralPubMed
7.
go back to reference Depasquale NP, Burch GE. The seasonal incidence of myocardial infarction in New Orleans. Am J Med Sci. 1961;242:468–74.PubMedCrossRef Depasquale NP, Burch GE. The seasonal incidence of myocardial infarction in New Orleans. Am J Med Sci. 1961;242:468–74.PubMedCrossRef
8.
go back to reference Heyer HE, Teng HC, Barris W. The increased frequency of acute myocardial infarction during summer months in a warm climate; a study of 1,386 cases from Dallas, Texas. Am Heart J. 1953;45:741–8.PubMedCrossRef Heyer HE, Teng HC, Barris W. The increased frequency of acute myocardial infarction during summer months in a warm climate; a study of 1,386 cases from Dallas, Texas. Am Heart J. 1953;45:741–8.PubMedCrossRef
9.
go back to reference Aronow WS, Ahn C. Elderly nursing home patients with congestive heart failure after myocardial infarction living in new york city have a higher prevalence of mortality in cold weather and warm weather months. J Gerontol A Biol Sci Med Sci. 2004;59:146–7.PubMedCrossRef Aronow WS, Ahn C. Elderly nursing home patients with congestive heart failure after myocardial infarction living in new york city have a higher prevalence of mortality in cold weather and warm weather months. J Gerontol A Biol Sci Med Sci. 2004;59:146–7.PubMedCrossRef
10.
go back to reference Martinez-Selles M, Garcia Robles JA, Prieto L, Serrano JA, Munoz R, Frades E, et al. Annual rates of admission and seasonal variations in hospitalizations for heart failure. Eur J Heart Fail. 2002;4:779–86.PubMedCrossRef Martinez-Selles M, Garcia Robles JA, Prieto L, Serrano JA, Munoz R, Frades E, et al. Annual rates of admission and seasonal variations in hospitalizations for heart failure. Eur J Heart Fail. 2002;4:779–86.PubMedCrossRef
11.•
go back to reference Gotsman I, Zwas D, Admon D, Lotan C, Keren A. Seasonal variation in hospital admission in patients with heart failure and its effect on prognosis. Cardiology. 2010; 117: 268–274. This epidemiological report showed that seasonal temperature had a significant effect on the rate of hospital admissions in patients with CHF. Gotsman I, Zwas D, Admon D, Lotan C, Keren A. Seasonal variation in hospital admission in patients with heart failure and its effect on prognosis. Cardiology. 2010; 117: 268–274. This epidemiological report showed that seasonal temperature had a significant effect on the rate of hospital admissions in patients with CHF.
12.
go back to reference Halonen JI, Zanobetti A, Sparrow D, Vokonas PS, Schwartz J. Relationship between outdoor temperature and blood pressure. Occup Environ Med. 2011;68:296–301.PubMedCrossRef Halonen JI, Zanobetti A, Sparrow D, Vokonas PS, Schwartz J. Relationship between outdoor temperature and blood pressure. Occup Environ Med. 2011;68:296–301.PubMedCrossRef
13.
go back to reference Alperovitch A, Lacombe JM, Hanon O, Dartigues JF, Ritchie K, Ducimetiere P, et al. Relationship between blood pressure and outdoor temperature in a large sample of elderly individuals: the Three-City study. Arch Intern Med. 2009;169:75–80.PubMedCrossRef Alperovitch A, Lacombe JM, Hanon O, Dartigues JF, Ritchie K, Ducimetiere P, et al. Relationship between blood pressure and outdoor temperature in a large sample of elderly individuals: the Three-City study. Arch Intern Med. 2009;169:75–80.PubMedCrossRef
14.
go back to reference Rowell LB. Circulatory adjustments to dynamic exercise and heat stress: competing controls. In: Rowell LB, editor. Human Circulation Regulation During Physical Stress. London: Oxford University Press; 1986. p. 363–406. Rowell LB. Circulatory adjustments to dynamic exercise and heat stress: competing controls. In: Rowell LB, editor. Human Circulation Regulation During Physical Stress. London: Oxford University Press; 1986. p. 363–406.
15.
go back to reference Rowell LB. Thermal Stress. In: Rowell LB, editor. Human Circulation Regulation During Physical Stress. London: Oxford University Press; 1986. p. 174–212. Rowell LB. Thermal Stress. In: Rowell LB, editor. Human Circulation Regulation During Physical Stress. London: Oxford University Press; 1986. p. 174–212.
16.
go back to reference Johnson JM, Proppe DW. Cardiovascular adjustments to heat stress. In: Fregly MJ, Blatteis CM, editors. Handbook of Physiology - Environmental Physiology. New York: Oxford University Press; 1996. p. 215–43. Johnson JM, Proppe DW. Cardiovascular adjustments to heat stress. In: Fregly MJ, Blatteis CM, editors. Handbook of Physiology - Environmental Physiology. New York: Oxford University Press; 1996. p. 215–43.
17.
go back to reference Damato AN, Lau SH, Stein E, Haft JI, Kosowsky B, Cohen SI. Cardiovascular response to acute thermal stress (hot dry environment) in unacclimatized normal subjects. Am Heart J. 1968;76:769–74.PubMedCrossRef Damato AN, Lau SH, Stein E, Haft JI, Kosowsky B, Cohen SI. Cardiovascular response to acute thermal stress (hot dry environment) in unacclimatized normal subjects. Am Heart J. 1968;76:769–74.PubMedCrossRef
18.
go back to reference Rowell LB, Brengelmann GL, Murray JA. Cardiovascular responses to sustained high skin temperature in resting man. J Appl Physiol. 1969;27:673–80.PubMed Rowell LB, Brengelmann GL, Murray JA. Cardiovascular responses to sustained high skin temperature in resting man. J Appl Physiol. 1969;27:673–80.PubMed
19.
go back to reference Minson CT, Wladkowski SL, Cardell AF, Pawelczyk JA, Kenney WL. Age alters the cardiovascular response to direct passive heating. J Appl Physiol. 1998;84:1323–32.PubMed Minson CT, Wladkowski SL, Cardell AF, Pawelczyk JA, Kenney WL. Age alters the cardiovascular response to direct passive heating. J Appl Physiol. 1998;84:1323–32.PubMed
20.
go back to reference Rowell LB, Brengelmann GL, Blackmon JR, Murray JA. Redistribution of blood flow during sustained high skin temperature in resting man. J Appl Physiol. 1970;28:415–20.PubMed Rowell LB, Brengelmann GL, Blackmon JR, Murray JA. Redistribution of blood flow during sustained high skin temperature in resting man. J Appl Physiol. 1970;28:415–20.PubMed
21.
go back to reference Rowell LB, Detry JR, Profant GR, Wyss C. Splanchnic vasoconstriction in hyperthermic man–role of falling blood pressure. J Appl Physiol. 1971;31:864–9.PubMed Rowell LB, Detry JR, Profant GR, Wyss C. Splanchnic vasoconstriction in hyperthermic man–role of falling blood pressure. J Appl Physiol. 1971;31:864–9.PubMed
22.
go back to reference Heinonen I, Brothers RM, Kemppainen J, Knuuti J, Kalliokoski KK, Crandall CG. Local heating, but not indirect whole body heating, increases human skeletal muscle blood flow. J Appl Physiol. 2011;111:818–24.PubMedCentralPubMedCrossRef Heinonen I, Brothers RM, Kemppainen J, Knuuti J, Kalliokoski KK, Crandall CG. Local heating, but not indirect whole body heating, increases human skeletal muscle blood flow. J Appl Physiol. 2011;111:818–24.PubMedCentralPubMedCrossRef
23.
go back to reference Detry JM, Brengelmann GL, Rowell LB, Wyss C. Skin and muscle components of forearm blood flow in directly heated resting man. J Appl Physiol. 1972;32:506–11.PubMed Detry JM, Brengelmann GL, Rowell LB, Wyss C. Skin and muscle components of forearm blood flow in directly heated resting man. J Appl Physiol. 1972;32:506–11.PubMed
24.
go back to reference Edholm OG, Fox RH, MacPherson RK. The effect of body heating on the circulation in skin and muscle. J Physiol. 1956;134:612–9.PubMedCentralPubMed Edholm OG, Fox RH, MacPherson RK. The effect of body heating on the circulation in skin and muscle. J Physiol. 1956;134:612–9.PubMedCentralPubMed
25.
go back to reference Roddie IC, Shepherd JT, Whelan RF. Evidence from venous oxygen saturation measurements that the increase in forearm blood flow during body heating is confined to the skin. J Physiol. 1956;134:444–50.PubMedCentralPubMed Roddie IC, Shepherd JT, Whelan RF. Evidence from venous oxygen saturation measurements that the increase in forearm blood flow during body heating is confined to the skin. J Physiol. 1956;134:444–50.PubMedCentralPubMed
26.
go back to reference Cui J, Wilson TE, Crandall CG. Baroreflex modulation of sympathetic nerve activity to muscle in heat-stressed humans. Am J Physiol Regul Integr Comp Physiol. 2002;282:R252–8.PubMed Cui J, Wilson TE, Crandall CG. Baroreflex modulation of sympathetic nerve activity to muscle in heat-stressed humans. Am J Physiol Regul Integr Comp Physiol. 2002;282:R252–8.PubMed
27.
go back to reference Cui J, Wilson TE, Crandall CG. Phenylephrine-induced elevations in arterial blood pressure are attenuated in heat-stressed humans. Am J Physiol Regul Integr Comp Physiol. 2002;283:R1221–6.PubMed Cui J, Wilson TE, Crandall CG. Phenylephrine-induced elevations in arterial blood pressure are attenuated in heat-stressed humans. Am J Physiol Regul Integr Comp Physiol. 2002;283:R1221–6.PubMed
28.
go back to reference Cui J, Wilson TE, Crandall CG. Muscle sympathetic nerve activity during lower body negative pressure is accentuated in heat-stressed humans. J Appl Physiol. 2004;96:2103–8.PubMedCrossRef Cui J, Wilson TE, Crandall CG. Muscle sympathetic nerve activity during lower body negative pressure is accentuated in heat-stressed humans. J Appl Physiol. 2004;96:2103–8.PubMedCrossRef
29.
go back to reference Crandall CG, Etzel RA, Farr DB. Cardiopulmonary baroreceptor control of muscle sympathetic nerve activity in heat-stressed humans. Am J Physiol Heart Circ Physiol. 1999;277:H2348–52. Crandall CG, Etzel RA, Farr DB. Cardiopulmonary baroreceptor control of muscle sympathetic nerve activity in heat-stressed humans. Am J Physiol Heart Circ Physiol. 1999;277:H2348–52.
30.
go back to reference Niimi Y, Matsukawa T, Sugiyama Y, Shamsuzzaman AS, Ito H, Sobue G, et al. Effect of heat stress on muscle sympathetic nerve activity in humans. J Auton Nerv Syst. 1997;63:61–7.PubMedCrossRef Niimi Y, Matsukawa T, Sugiyama Y, Shamsuzzaman AS, Ito H, Sobue G, et al. Effect of heat stress on muscle sympathetic nerve activity in humans. J Auton Nerv Syst. 1997;63:61–7.PubMedCrossRef
32.
go back to reference Keller DM, Sander M, Stallknecht B, Crandall CG. alpha-Adrenergic vasoconstrictor responsiveness is preserved in the heated human leg. J Physiol. 2010;588:3799–808.PubMedCentralPubMedCrossRef Keller DM, Sander M, Stallknecht B, Crandall CG. alpha-Adrenergic vasoconstrictor responsiveness is preserved in the heated human leg. J Physiol. 2010;588:3799–808.PubMedCentralPubMedCrossRef
33.
go back to reference Crandall CG, Zhang R, Levine BD. Effects of whole body heating on dynamic baroreflex regulation of heart rate in humans. Am J Physiol Heart Circ Physiol. 2000;279:H2486–92.PubMed Crandall CG, Zhang R, Levine BD. Effects of whole body heating on dynamic baroreflex regulation of heart rate in humans. Am J Physiol Heart Circ Physiol. 2000;279:H2486–92.PubMed
34.
go back to reference Cui J, Zhang R, Wilson TE, Crandall CG. Spectral analysis of muscle sympathetic nerve activity in heat-stressed humans. Am J Physiol Heart Circ Physiol. 2004;286:H1101–6.PubMedCrossRef Cui J, Zhang R, Wilson TE, Crandall CG. Spectral analysis of muscle sympathetic nerve activity in heat-stressed humans. Am J Physiol Heart Circ Physiol. 2004;286:H1101–6.PubMedCrossRef
35.
go back to reference Cui J, Sathishkumar M, Wilson TE, Shibasaki M, Davis SL, Crandall CG. Spectral characteristics of skin sympathetic nerve activity in heat-stressed humans. Am J Physiol Heart Circ Physiol. 2006;290:H1601–9.PubMedCrossRef Cui J, Sathishkumar M, Wilson TE, Shibasaki M, Davis SL, Crandall CG. Spectral characteristics of skin sympathetic nerve activity in heat-stressed humans. Am J Physiol Heart Circ Physiol. 2006;290:H1601–9.PubMedCrossRef
36.
go back to reference Keller DM, Cui J, Davis SL, Low DA, Crandall CG. Heat stress enhances arterial baroreflex control of muscle sympathetic nerve activity via increased sensitivity of burst gating, not burst area, in humans. J Physiol. 2006;573:445–51.PubMedCentralPubMedCrossRef Keller DM, Cui J, Davis SL, Low DA, Crandall CG. Heat stress enhances arterial baroreflex control of muscle sympathetic nerve activity via increased sensitivity of burst gating, not burst area, in humans. J Physiol. 2006;573:445–51.PubMedCentralPubMedCrossRef
37.
go back to reference Yamazaki F, Okuno C, Nagamatsu S, Sone R. Effects of whole-body and local thermal stress on hydrostatic volume changes in the human calf. Eur J Appl Physiol. 2002;88:61–6.PubMedCrossRef Yamazaki F, Okuno C, Nagamatsu S, Sone R. Effects of whole-body and local thermal stress on hydrostatic volume changes in the human calf. Eur J Appl Physiol. 2002;88:61–6.PubMedCrossRef
38.
go back to reference Kellogg Jr DL, Johnson JM, Kosiba WA. Selective abolition of adrenergic vasoconstrictor responses in skin by local iontophoresis of bretylium. Am J Physiol Heart Circ Physiol. 1989;257:H1599–606. Kellogg Jr DL, Johnson JM, Kosiba WA. Selective abolition of adrenergic vasoconstrictor responses in skin by local iontophoresis of bretylium. Am J Physiol Heart Circ Physiol. 1989;257:H1599–606.
39.
go back to reference Stephens DP, Aoki K, Kosiba WA, Johnson JM. Nonnoradrenergic mechanism of reflex cutaneous vasoconstriction in men. Am J Physiol Heart Circ Physiol. 2001;280:H1496–504.PubMed Stephens DP, Aoki K, Kosiba WA, Johnson JM. Nonnoradrenergic mechanism of reflex cutaneous vasoconstriction in men. Am J Physiol Heart Circ Physiol. 2001;280:H1496–504.PubMed
40.
go back to reference Bini G, Hagbarth K-E, Hynninen P, Wallin BG. Thermoregulatory and rhythm-generating mechanisms governing the sudomotor and vasoconstrictor outflow in human cutaneous nerves. J Physiol Lond. 1980;306:537–52.PubMedCentralPubMed Bini G, Hagbarth K-E, Hynninen P, Wallin BG. Thermoregulatory and rhythm-generating mechanisms governing the sudomotor and vasoconstrictor outflow in human cutaneous nerves. J Physiol Lond. 1980;306:537–52.PubMedCentralPubMed
41.
go back to reference Roddie IC, Shepherd JT, Whelan RF. The contribution of constrictor and dilator nerves to the skin vasodilatation during body heating. J Physiol. 1957;136:489–97.PubMedCentralPubMed Roddie IC, Shepherd JT, Whelan RF. The contribution of constrictor and dilator nerves to the skin vasodilatation during body heating. J Physiol. 1957;136:489–97.PubMedCentralPubMed
42.
go back to reference Joyner MJ, Halliwill R. Sympathetic vasodilatation in human limbs. J Physiol. 2000;526:471–80.PubMed Joyner MJ, Halliwill R. Sympathetic vasodilatation in human limbs. J Physiol. 2000;526:471–80.PubMed
43.
go back to reference Edholm OG, Fox RH, Macpherson RK. Vasomotor control of the cutaneous blood vessels in the human forearm. J Physiol. 1957;139:455–65.PubMedCentralPubMed Edholm OG, Fox RH, Macpherson RK. Vasomotor control of the cutaneous blood vessels in the human forearm. J Physiol. 1957;139:455–65.PubMedCentralPubMed
44.
go back to reference Kellogg Jr DL, Pergola PE, Piest KL, Kosiba WA, Crandall CG, Grossmann M, et al. Cutaneous active vasodilation in humans is mediated by cholinergic nerve cotransmission. Circ Res. 1995;77:1222–8.PubMedCrossRef Kellogg Jr DL, Pergola PE, Piest KL, Kosiba WA, Crandall CG, Grossmann M, et al. Cutaneous active vasodilation in humans is mediated by cholinergic nerve cotransmission. Circ Res. 1995;77:1222–8.PubMedCrossRef
45.
go back to reference Brengelmann GL, Freund PR, Rowell LB, Olerud JE, Kraning KK. Absence of active cutaneous vasodilation associated with congenital absence of sweat glands in humans. Am J Physiol Heart Circ Physiol. 1981;240:H571–5. Brengelmann GL, Freund PR, Rowell LB, Olerud JE, Kraning KK. Absence of active cutaneous vasodilation associated with congenital absence of sweat glands in humans. Am J Physiol Heart Circ Physiol. 1981;240:H571–5.
46.
go back to reference Hokfelt T, Johansson O, Ljungdahl A, Lundberg JM, Schultzberg M. Peptidergic neurones. Nature. 1980;284:515–21.PubMedCrossRef Hokfelt T, Johansson O, Ljungdahl A, Lundberg JM, Schultzberg M. Peptidergic neurones. Nature. 1980;284:515–21.PubMedCrossRef
47.
go back to reference Iwase S, Cui J, Wallin BG, Kamiya A, Mano T. Effects of increased ambient temperature on skin sympathetic nerve activity and core temperature in humans. Neurosci Lett. 2002;327:37–40.PubMedCrossRef Iwase S, Cui J, Wallin BG, Kamiya A, Mano T. Effects of increased ambient temperature on skin sympathetic nerve activity and core temperature in humans. Neurosci Lett. 2002;327:37–40.PubMedCrossRef
48.
go back to reference Cui J, Arbab-Zadeh A, Prasad A, Durand S, Levine BD, Crandall CG. Effects of heat stress on thermoregulatory responses in congestive heart failure patients. Circulation. 2005;112:2286–92.PubMedCrossRef Cui J, Arbab-Zadeh A, Prasad A, Durand S, Levine BD, Crandall CG. Effects of heat stress on thermoregulatory responses in congestive heart failure patients. Circulation. 2005;112:2286–92.PubMedCrossRef
49.
go back to reference Green DJ, Maiorana AJ, Siong JH, Burke V, Erickson M, Minson CT, et al. Impaired skin blood flow response to environmental heating in chronic heart failure. Eur Heart J. 2006;27:338–43.PubMedCrossRef Green DJ, Maiorana AJ, Siong JH, Burke V, Erickson M, Minson CT, et al. Impaired skin blood flow response to environmental heating in chronic heart failure. Eur Heart J. 2006;27:338–43.PubMedCrossRef
50.
go back to reference Grassi G, Seravalle G, Cattaneo BM, Lanfranchi A, Vailati S, Giannattasio C, et al. Sympathetic activation and loss of reflex sympathetic control in mild congestive heart failure. Circulation. 1995;92:3206–11.PubMedCrossRef Grassi G, Seravalle G, Cattaneo BM, Lanfranchi A, Vailati S, Giannattasio C, et al. Sympathetic activation and loss of reflex sympathetic control in mild congestive heart failure. Circulation. 1995;92:3206–11.PubMedCrossRef
51.
go back to reference Grassi G, Colombo M, Seravalle G, Spaziani D, Mancia G. Dissociation between muscle and skin sympathetic nerve activity in essential hypertension, obesity, and congestive heart failure. Hypertension. 1998;31:64–7.PubMedCrossRef Grassi G, Colombo M, Seravalle G, Spaziani D, Mancia G. Dissociation between muscle and skin sympathetic nerve activity in essential hypertension, obesity, and congestive heart failure. Hypertension. 1998;31:64–7.PubMedCrossRef
52.
go back to reference Silber DH, Sutliff G, Yang QX, Smith MB, Sinoway LI, Leuenberger UA. Altered mechanisms of sympathetic activation during rhythmic forearm exercise in heart failure. J Appl Physiol. 1998;84:1551–9.PubMedCrossRef Silber DH, Sutliff G, Yang QX, Smith MB, Sinoway LI, Leuenberger UA. Altered mechanisms of sympathetic activation during rhythmic forearm exercise in heart failure. J Appl Physiol. 1998;84:1551–9.PubMedCrossRef
53.
go back to reference Middlekauff HR, Hamilton MA, Stevenson LW, Mark AL. Independent control of skin and muscle sympathetic nerve activity in patients with heart failure. Circulation. 1994;90:1794–8.PubMedCrossRef Middlekauff HR, Hamilton MA, Stevenson LW, Mark AL. Independent control of skin and muscle sympathetic nerve activity in patients with heart failure. Circulation. 1994;90:1794–8.PubMedCrossRef
54.
go back to reference Zelis R, Mason DT, Braunwald E. A comparison of the effects of vasodilator stimuli on peripheral resistance vessels in normal subjects and in patients with congestive heart failure. J Clin Invest. 1968;47:960–70.PubMedCentralPubMedCrossRef Zelis R, Mason DT, Braunwald E. A comparison of the effects of vasodilator stimuli on peripheral resistance vessels in normal subjects and in patients with congestive heart failure. J Clin Invest. 1968;47:960–70.PubMedCentralPubMedCrossRef
55.
go back to reference Sinoway L, Minotti J, Musch T, Goldner D, Davis D, Leaman D, et al. Enhanced metabolic vasodilation secondary to diuretic therapy in decompensated congestive heart failure secondary to coronary artery disease. Am J Cardiol. 1987;60:107–11.PubMedCrossRef Sinoway L, Minotti J, Musch T, Goldner D, Davis D, Leaman D, et al. Enhanced metabolic vasodilation secondary to diuretic therapy in decompensated congestive heart failure secondary to coronary artery disease. Am J Cardiol. 1987;60:107–11.PubMedCrossRef
56.
go back to reference Wroblewski H, Norgaard T, Haunso S, Kastrup J. Microvascular distensibility in two different vascular beds in idiopathic dilated cardiomyopathy. Am J Physiol Heart Circ Physiol. 1995;269:H1973–80. Wroblewski H, Norgaard T, Haunso S, Kastrup J. Microvascular distensibility in two different vascular beds in idiopathic dilated cardiomyopathy. Am J Physiol Heart Circ Physiol. 1995;269:H1973–80.
57.
go back to reference Drexler H, Hayoz D, Munzel T. Endothelium function in chronic congestive heart failure. Am J Cardiol. 1992;69:1596–601.PubMedCrossRef Drexler H, Hayoz D, Munzel T. Endothelium function in chronic congestive heart failure. Am J Cardiol. 1992;69:1596–601.PubMedCrossRef
58.
go back to reference Kubo SH, Rector TS, Bank AJ, Williams RE, Heifetz SM. Endothelium-dependent vasodilation is attenuated in patients with heart failure. Circulation. 1991;84:1589–96.PubMedCrossRef Kubo SH, Rector TS, Bank AJ, Williams RE, Heifetz SM. Endothelium-dependent vasodilation is attenuated in patients with heart failure. Circulation. 1991;84:1589–96.PubMedCrossRef
59.
go back to reference Andreassen AK, Gullestad L, Holm T, Simonsen S, Kvernebo K. Endothelium-dependent vasodilation of the skin microcirculation in heart transplant recipients. Clin Transplant. 1998;12:324–32.PubMed Andreassen AK, Gullestad L, Holm T, Simonsen S, Kvernebo K. Endothelium-dependent vasodilation of the skin microcirculation in heart transplant recipients. Clin Transplant. 1998;12:324–32.PubMed
60.
go back to reference Andersson SE, Edvinsson ML, Edvinsson L. Cutaneous vascular reactivity is reduced in aging and in heart failure: association with inflammation. Clin Sci (Lond). 2003;105:699–707.CrossRef Andersson SE, Edvinsson ML, Edvinsson L. Cutaneous vascular reactivity is reduced in aging and in heart failure: association with inflammation. Clin Sci (Lond). 2003;105:699–707.CrossRef
61.
go back to reference Ramsey MW, Goodfellow J, Jones CJ, Luddington LA, Lewis MJ, Henderson AH. Endothelial control of arterial distensibility is impaired in chronic heart failure. Circulation. 1995;92:3212–9.PubMedCrossRef Ramsey MW, Goodfellow J, Jones CJ, Luddington LA, Lewis MJ, Henderson AH. Endothelial control of arterial distensibility is impaired in chronic heart failure. Circulation. 1995;92:3212–9.PubMedCrossRef
62.
go back to reference Hornig B, Maier V, Drexler H. Physical training improves endothelial function in patients with chronic heart failure. Circulation. 1996;93:210–4.PubMedCrossRef Hornig B, Maier V, Drexler H. Physical training improves endothelial function in patients with chronic heart failure. Circulation. 1996;93:210–4.PubMedCrossRef
63.
go back to reference Kellogg Jr DL, Liu Y, Kosiba IF, O'Donnell D. Role of nitric oxide in the vascular effects of local warming of the skin in humans. J Appl Physiol. 1999;86:1185–90.PubMed Kellogg Jr DL, Liu Y, Kosiba IF, O'Donnell D. Role of nitric oxide in the vascular effects of local warming of the skin in humans. J Appl Physiol. 1999;86:1185–90.PubMed
64.
go back to reference Minson CT, Berry LT, Joyner MJ. Nitric oxide and neurally mediated regulation of skin blood flow during local heating. J Appl Physiol. 2001;91:1619–26.PubMed Minson CT, Berry LT, Joyner MJ. Nitric oxide and neurally mediated regulation of skin blood flow during local heating. J Appl Physiol. 2001;91:1619–26.PubMed
65.
go back to reference Kellogg Jr DL, Crandall CG, Liu Y, Charkoudian N, Johnson JM. Nitric oxide and cutaneous active vasodilation during heat stress in humans. J Appl Physiol. 1998;85:824–9.PubMed Kellogg Jr DL, Crandall CG, Liu Y, Charkoudian N, Johnson JM. Nitric oxide and cutaneous active vasodilation during heat stress in humans. J Appl Physiol. 1998;85:824–9.PubMed
66.
go back to reference Shastry S, Dietz NM, Halliwill JR, Reed AS, Joyner MJ. Effects of nitric oxide synthase inhibition on cutaneous vasodilation during body heating in humans. J Appl Physiol. 1998;85:830–4.PubMed Shastry S, Dietz NM, Halliwill JR, Reed AS, Joyner MJ. Effects of nitric oxide synthase inhibition on cutaneous vasodilation during body heating in humans. J Appl Physiol. 1998;85:830–4.PubMed
67.
go back to reference Katz SD, Biasucci L, Sabba C, Strom JA, Jondeau G, Galvao M, et al. Impaired endothelium-mediated vasodilation in the peripheral vasculature of patients with congestive heart failure. J Am Coll Cardiol. 1992;19:918–25.PubMedCrossRef Katz SD, Biasucci L, Sabba C, Strom JA, Jondeau G, Galvao M, et al. Impaired endothelium-mediated vasodilation in the peripheral vasculature of patients with congestive heart failure. J Am Coll Cardiol. 1992;19:918–25.PubMedCrossRef
68.•
go back to reference Cui J, Boehmer JP, Blaha C, Lucking R, Kunselman AR, Sinoway LI. Chronic heart failure does not attenuate the total activity of sympathetic outflow to skin during whole-body heating. Circ Heart Fail. 2013; 6: 271–278. PMC 3738175. This study showed that the cutaneous vasodilation during heat stress was significantly attenuated, while the response of skin sympathetic nerve activity to heat stress was not altered in CHF patients when compared with healthy control subjects. Cui J, Boehmer JP, Blaha C, Lucking R, Kunselman AR, Sinoway LI. Chronic heart failure does not attenuate the total activity of sympathetic outflow to skin during whole-body heating. Circ Heart Fail. 2013; 6: 271–278. PMC 3738175. This study showed that the cutaneous vasodilation during heat stress was significantly attenuated, while the response of skin sympathetic nerve activity to heat stress was not altered in CHF patients when compared with healthy control subjects.
69.
go back to reference Morgan CL, Nadas AS. Sweating and congestive heart failure. N Engl J Med. 1963;268:580–5.CrossRef Morgan CL, Nadas AS. Sweating and congestive heart failure. N Engl J Med. 1963;268:580–5.CrossRef
70.
go back to reference Mack GW, Shannon LM, Nadel ER. Influence of beta-adrenergic blockade on the control of sweating in humans. J Appl Physiol. 1986;61:1701–5.PubMed Mack GW, Shannon LM, Nadel ER. Influence of beta-adrenergic blockade on the control of sweating in humans. J Appl Physiol. 1986;61:1701–5.PubMed
71.
go back to reference Freund BJ, Joyner MJ, Jilka SM, Kalis J, Nittolo JM, Taylor JA, et al. Thermoregulation during prolonged exercise in heat: alterations with beta-adrenergic blockade. J Appl Physiol. 1987;63:930–6.PubMed Freund BJ, Joyner MJ, Jilka SM, Kalis J, Nittolo JM, Taylor JA, et al. Thermoregulation during prolonged exercise in heat: alterations with beta-adrenergic blockade. J Appl Physiol. 1987;63:930–6.PubMed
72.
go back to reference Pescatello LS, Mack GW, Leach Jr CN, Nadel ER. Thermoregulation in mildly hypertensive men during beta-adrenergic blockade. Med Sci Sports Exerc. 1990;22:222–8.PubMedCrossRef Pescatello LS, Mack GW, Leach Jr CN, Nadel ER. Thermoregulation in mildly hypertensive men during beta-adrenergic blockade. Med Sci Sports Exerc. 1990;22:222–8.PubMedCrossRef
73.
go back to reference Crandall CG, Wilson TE, Marving J, Vogelsang TW, Kjaer A, Hesse B, et al. Effects of passive heating on central blood volume and ventricular dimensions in humans. J Physiol. 2008;586:293–301.PubMedCentralPubMedCrossRef Crandall CG, Wilson TE, Marving J, Vogelsang TW, Kjaer A, Hesse B, et al. Effects of passive heating on central blood volume and ventricular dimensions in humans. J Physiol. 2008;586:293–301.PubMedCentralPubMedCrossRef
74.
go back to reference Brothers RM, Bhella PS, Shibata S, Wingo JE, Levine BD, Crandall CG. Cardiac systolic and diastolic function during whole body heat stress. Am J Physiol Heart Circ Physiol. 2009;296:H1150–6.PubMedCentralPubMedCrossRef Brothers RM, Bhella PS, Shibata S, Wingo JE, Levine BD, Crandall CG. Cardiac systolic and diastolic function during whole body heat stress. Am J Physiol Heart Circ Physiol. 2009;296:H1150–6.PubMedCentralPubMedCrossRef
75.
go back to reference Wilson TE, Tollund C, Yoshiga CC, Dawson EA, Nissen P, Secher NH, et al. Effects of heat and cold stress on central vascular pressure relationships during orthostasis in humans. J Physiol. 2007;585:279–85.PubMedCentralPubMedCrossRef Wilson TE, Tollund C, Yoshiga CC, Dawson EA, Nissen P, Secher NH, et al. Effects of heat and cold stress on central vascular pressure relationships during orthostasis in humans. J Physiol. 2007;585:279–85.PubMedCentralPubMedCrossRef
76.
go back to reference Wilson TE, Brothers RM, Tollund C, Dawson EA, Nissen P, Yoshiga CC, et al. Effect of thermal stress on Frank-Starling relations in humans. J Physiol. 2009;587:3383–92.PubMedCentralPubMedCrossRef Wilson TE, Brothers RM, Tollund C, Dawson EA, Nissen P, Yoshiga CC, et al. Effect of thermal stress on Frank-Starling relations in humans. J Physiol. 2009;587:3383–92.PubMedCentralPubMedCrossRef
77.•
go back to reference Oyama J, Kudo Y, Maeda T, Node K, Makino N. Hyperthermia by bathing in a hot spring improves cardiovascular functions and reduces the production of inflammatory cytokines in patients with chronic heart failure. Heart Vessels. 2013; 28: 173–178. This recent study demonstrated that two weeks of repeated moderate heat exposure improved ventricular ejection fraction and cardiothoracic ratio in CHF patients. Moreover, the inflammatory responses decreased after the treatment. Oyama J, Kudo Y, Maeda T, Node K, Makino N. Hyperthermia by bathing in a hot spring improves cardiovascular functions and reduces the production of inflammatory cytokines in patients with chronic heart failure. Heart Vessels. 2013; 28: 173–178. This recent study demonstrated that two weeks of repeated moderate heat exposure improved ventricular ejection fraction and cardiothoracic ratio in CHF patients. Moreover, the inflammatory responses decreased after the treatment.
78.
go back to reference Michalsen A, Ludtke R, Buhring M, Spahn G, Langhorst J, Dobos GJ. Thermal hydrotherapy improves quality of life and hemodynamic function in patients with chronic heart failure. Am Heart J. 2003;146:E11.CrossRef Michalsen A, Ludtke R, Buhring M, Spahn G, Langhorst J, Dobos GJ. Thermal hydrotherapy improves quality of life and hemodynamic function in patients with chronic heart failure. Am Heart J. 2003;146:E11.CrossRef
79.
go back to reference Imamura M, Biro S, Kihara T, Yoshifuku S, Takasaki K, Otsuji Y, et al. Repeated thermal therapy improves impaired vascular endothelial function in patients with coronary risk factors. J Am Coll Cardiol. 2001;38:1083–8.PubMedCrossRef Imamura M, Biro S, Kihara T, Yoshifuku S, Takasaki K, Otsuji Y, et al. Repeated thermal therapy improves impaired vascular endothelial function in patients with coronary risk factors. J Am Coll Cardiol. 2001;38:1083–8.PubMedCrossRef
80.
go back to reference Kihara T, Biro S, Imamura M, Yoshifuku S, Takasaki K, Ikeda Y, et al. Repeated sauna treatment improves vascular endothelial and cardiac function in patients with chronic heart failure. J Am Coll Cardiol. 2002;39:754–9.PubMedCrossRef Kihara T, Biro S, Imamura M, Yoshifuku S, Takasaki K, Ikeda Y, et al. Repeated sauna treatment improves vascular endothelial and cardiac function in patients with chronic heart failure. J Am Coll Cardiol. 2002;39:754–9.PubMedCrossRef
81.
go back to reference Tei C, Horikiri Y, Park JC, Jeong JW, Chang KS, Toyama Y, et al. Acute hemodynamic improvement by thermal vasodilation in congestive heart failure. Circulation. 1995;91:2582–90.PubMedCrossRef Tei C, Horikiri Y, Park JC, Jeong JW, Chang KS, Toyama Y, et al. Acute hemodynamic improvement by thermal vasodilation in congestive heart failure. Circulation. 1995;91:2582–90.PubMedCrossRef
82.
go back to reference Weber AA, Silver MA. Heat therapy in the management of heart failure. Congest Heart Fail. 2007;13:81–3.PubMedCrossRef Weber AA, Silver MA. Heat therapy in the management of heart failure. Congest Heart Fail. 2007;13:81–3.PubMedCrossRef
83.
go back to reference Kisanuki A, Daitoku S, Kihara T, Otsuji Y, Tei C. Thermal therapy improves left ventricular diastolic function in patients with congestive heart failure: a tissue doppler echocardiographic study. J Cardiol. 2007;49:187–91.PubMed Kisanuki A, Daitoku S, Kihara T, Otsuji Y, Tei C. Thermal therapy improves left ventricular diastolic function in patients with congestive heart failure: a tissue doppler echocardiographic study. J Cardiol. 2007;49:187–91.PubMed
84.
go back to reference Tei C, Shinsato T, Miyata M, Kihara T, Hamasaki S. Waon therapy improves peripheral arterial disease. J Am Coll Cardiol. 2007;50:2169–71.PubMedCrossRef Tei C, Shinsato T, Miyata M, Kihara T, Hamasaki S. Waon therapy improves peripheral arterial disease. J Am Coll Cardiol. 2007;50:2169–71.PubMedCrossRef
85.
go back to reference Shinsato T, Miyata M, Kubozono T, Ikeda Y, Fujita S, Kuwahata S, et al. Waon therapy mobilizes CD34+ cells and improves peripheral arterial disease. J Cardiol. 2010;56:361–6.PubMedCrossRef Shinsato T, Miyata M, Kubozono T, Ikeda Y, Fujita S, Kuwahata S, et al. Waon therapy mobilizes CD34+ cells and improves peripheral arterial disease. J Cardiol. 2010;56:361–6.PubMedCrossRef
87.
go back to reference Radak Z, Chung HY, Koltai E, Taylor AW, Goto S. Exercise, oxidative stress and hormesis. Ageing Res Rev. 2008;7:34–42.PubMedCrossRef Radak Z, Chung HY, Koltai E, Taylor AW, Goto S. Exercise, oxidative stress and hormesis. Ageing Res Rev. 2008;7:34–42.PubMedCrossRef
Metadata
Title
Cardiovascular Responses to Heat Stress in Chronic Heart Failure
Authors
Jian Cui
Lawrence I. Sinoway
Publication date
01-06-2014
Publisher
Springer US
Published in
Current Heart Failure Reports / Issue 2/2014
Print ISSN: 1546-9530
Electronic ISSN: 1546-9549
DOI
https://doi.org/10.1007/s11897-014-0191-y

Other articles of this Issue 2/2014

Current Heart Failure Reports 2/2014 Go to the issue

Pathophysiology: Neuroendocrine, Vascular, and Metabolic Factors (SD Katz, Section Editor)

Heart Failure and Obesity in Adults: Pathophysiology, Clinical Manifestations and Management

Management of Heart Failure (TE Meyer, Section Editor)

Polypharmacy in Heart Failure Patients

Management of Heart Failure (TE Meyer, Section Editor)

Interventions for Heart Failure Readmissions: Successes and Failures

Pathophysiology: Neuroendocrine, Vascular, and Metabolic Factors (SD Katz, Section Editor)

Neuregulin-1 Signaling in the Pathogenesis of Chemotherapy-Induced Heart Failure

Management of Heart Failure (TE Meyer, Section Editor)

Determinants of Survival Following Hospitalization for Acute Heart Failure

Live Webinar | 27-06-2024 | 18:00 (CEST)

Keynote webinar | Spotlight on medication adherence

Live: Thursday 27th June 2024, 18:00-19:30 (CEST)

WHO estimates that half of all patients worldwide are non-adherent to their prescribed medication. The consequences of poor adherence can be catastrophic, on both the individual and population level.

Join our expert panel to discover why you need to understand the drivers of non-adherence in your patients, and how you can optimize medication adherence in your clinics to drastically improve patient outcomes.

Prof. Kevin Dolgin
Prof. Florian Limbourg
Prof. Anoop Chauhan
Developed by: Springer Medicine
Obesity Clinical Trial Summary

At a glance: The STEP trials

A round-up of the STEP phase 3 clinical trials evaluating semaglutide for weight loss in people with overweight or obesity.

Developed by: Springer Medicine

Highlights from the ACC 2024 Congress

Year in Review: Pediatric cardiology

Watch Dr. Anne Marie Valente present the last year's highlights in pediatric and congenital heart disease in the official ACC.24 Year in Review session.

Year in Review: Pulmonary vascular disease

The last year's highlights in pulmonary vascular disease are presented by Dr. Jane Leopold in this official video from ACC.24.

Year in Review: Valvular heart disease

Watch Prof. William Zoghbi present the last year's highlights in valvular heart disease from the official ACC.24 Year in Review session.

Year in Review: Heart failure and cardiomyopathies

Watch this official video from ACC.24. Dr. Biykem Bozkurt discusses last year's major advances in heart failure and cardiomyopathies.