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Published in:

01-06-2010

Cardioprotection in the Clinical Setting

Authors: Fabrice Ivanes, Nathan Mewton, Gilles Rioufol, Christophe Piot, Meyer Elbaz, Didier Revel, Pierre Croisille, Michel Ovize

Published in: Cardiovascular Drugs and Therapy | Issue 3/2010

Abstract

Reperfusion therapy is the primary treatment of acute myocardial infarction and must be applied as soon as possible to limit the ischemic insult. Unfortunately, reperfusion is responsible for additional myocardial damage likely involving opening of the mitochondrial permeability transition pore. Ischemic postconditioning is a powerful intervention that dramatically reduces lethal reperfusion injury. Several clinical studies using angioplasty postconditioning now support its protective effects in patients with an acute myocardial infarction. Alternatively, pharmacological postconditioning could afford comparable protection and be applied to a much larger number of patients. Indeed, the mitochondrial permeability transition pore inhibitor cyclosporine A has been shown to generate a similar protection in acute myocardial infarction patients. Future large-scale trials are needed to determine whether angioplasty or pharmacological postconditioning may improve clinical outcome in STEMI patients.

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Title: Cardioprotection in the Clinical Setting
Authors: Fabrice Ivanes
Nathan Mewton
Gilles Rioufol
Christophe Piot
Meyer Elbaz
Didier Revel
Pierre Croisille
Michel Ovize
Publication date: 01-06-2010
Publisher: Springer US
Published in: Cardiovascular Drugs and Therapy / Issue 3/2010
Print ISSN: 0920-3206
Electronic ISSN: 1573-7241
DOI: https://doi.org/10.1007/s10557-010-6243-y

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