The ability to quantify absolute myocardial blood flow (MBF) represents a game changer for the field of nuclear cardiology. MBF reserve (MBFR), the ratio of stress to resting MBF, can be accurately and reproducibly measured with PET myocardial perfusion imaging (MPI) using the PET flow tracers 15O-water, 13N-ammonia, or 82rubidium chloride. PET MBFR has firmly achieved “prime-time” status. PET MBFR has a category I CPT code, confirming MBFR is a well established and clinically useful imaging procedure; and the use of MBFR with PET was endorsed by the 2021 multi-societal chest pain guideline.1