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Open Access 01-12-2010 | Research

Carbonic anhydrase XII expression is associated with histologic grade of cervical cancer and superior radiotherapy outcome

Authors: Chong Woo Yoo, Byung-Ho Nam, Joo-Young Kim, Hye-Jin Shin, Hyunsun Lim, Sun Lee, Su-Kyoung Lee, Myong-Cheol Lim, Yong-Jung Song

Published in: Radiation Oncology | Issue 1/2010

Abstract

Background

To investigate whether expression of carbonic anhydrase XII (CA12) is associated with histologic grade of the tumors and radiotherapy outcomes of the patients with invasive cervical cancer.

Methods

CA12 expression was examined by immunohistochemical stains in cervical cancer tissues from 183 radiotherapy patients. Histological grading was classified as well (WD), moderately (MD) or poorly differentiated (PD). Oligonucleotide microarray experiment was performed using seven cervical cancer samples to examine differentially expressed genes between WD and PD cervical cancers. The association between CA12 and histological grade was analyzed by chi-square test. CA12 and histological grades were analyzed individually and as combined CA12 and histologic grade categories for effects on survival outcome.

Results

Immunohistochemical expression of CA12 was highly associated with the histologic grade of cervical cancer. Lack of CA12 expression was associated with PD histology, with an odds ratio of 3.9 (P = 0.01). Microarray analysis showed a fourfold reduction in CA12 gene expression in PD tumors. CA12 expression was marginally associated with superior disease-free survival. Application of the new combined categories resulted in further discrimination of the prognosis of patients with moderate and poorly differentiated tumor grade.

Conclusions

Our study indicates that CA12 may be used as a novel prognostic marker in combination with histologic grade of the tumors.

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Title: Carbonic anhydrase XII expression is associated with histologic grade of cervical cancer and superior radiotherapy outcome
Authors: Chong Woo Yoo
Byung-Ho Nam
Joo-Young Kim
Hye-Jin Shin
Hyunsun Lim
Sun Lee
Su-Kyoung Lee
Myong-Cheol Lim
Yong-Jung Song
Publication date: 01-12-2010
Publisher: BioMed Central
Published in: Radiation Oncology / Issue 1/2010
Electronic ISSN: 1748-717X
DOI: https://doi.org/10.1186/1748-717X-5-101

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Carbonic anhydrase XII expression is associated with histologic grade of cervical cancer and superior radiotherapy outcome

Abstract

Background

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Methods

Results

Conclusions

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