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Keynote webinar | Spotlight on medication adherence

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Journal of Clinical Immunology
Published in: Journal of Clinical Immunology 4/2024

Open Access 01-04-2024 | CAR T-Cell Therapy | Letter to Editor

Monozygotic Twins with MAGT1 Deficiency and Epstein–Barr virus-positive Classic Hodgkin Lymphoma Receiving anti-CD30 CAR T-cell Immunotherapy: A case Report

Authors: Jiachen Wang, Mi Zhou, Jianfeng Zhou, Min Xiao, Liang Huang

Published in: Journal of Clinical Immunology | Issue 4/2024

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Excerpt

Epstein-Barr virus (EBV)-positive classical Hodgkin lymphoma (cHL) is the most common malignancy in patients with “X-linked immunodeficiency with magnesium defect, EBV infection, and neoplasia” (XMEN). Aberrant expression of MAGT1 leads to XMEN, a congenital disorder of combined primary immunodeficiency (PID) characterized by increased susceptibility to chronic EBV infection and EBV-associated lymphoproliferation [1]. Patients with variants in MAGT1 suffer from an N-linked glycosylation defect, resulting in low CD4+ cell counts with an inverted CD4:CD8 ratio, reduced expression of NKG2D (a natural killer (NK)-cell activating receptor) on NK cells and cytotoxic T lymphocytes (CTLs), and impaired T-cell activation through NKG2D [2]. …
Appendix
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Literature
1.
2.
Chaigne-Delalande B, Li FY, O’Connor GM, Lukacs MJ, Jiang P, Zheng L, et al. Mg2 + regulates cytotoxic functions of NK and CD8 T cells in chronic EBV infection through NKG2D. Science. 2013;341(6142):186–91.CrossRefPubMedPubMedCentral
3.
Klinken EM, Gray PE, Pillay B, Worley L, Edwards ESJ, Payne K, et al. Diversity of XMEN Disease: description of 2 novel variants and analysis of the lymphocyte phenotype. J Clin Immunol. 2020;40(2):299–309.CrossRefPubMed
4.
Wang D, Zeng C, Xu B, Xu JH, Wang J, Jiang LJ, et al. Anti-CD30 chimeric antigen receptor T cell therapy for relapsed/refractory CD30(+) lymphoma patients. Blood Cancer J. 2020;10(1):8.CrossRefPubMedPubMedCentral
5.
Brune MM, Juskevicius D, Haslbauer J, Dirnhofer S, Tzankov A. Genomic Landscape of Hodgkin Lymphoma. Cancers (Basel). 2021;13(4).
6.
Metadata
Title
Monozygotic Twins with MAGT1 Deficiency and Epstein–Barr virus-positive Classic Hodgkin Lymphoma Receiving anti-CD30 CAR T-cell Immunotherapy: A case Report
Authors
Jiachen Wang
Mi Zhou
Jianfeng Zhou
Min Xiao
Liang Huang
Publication date
01-04-2024
Publisher
Springer US
Published in
Journal of Clinical Immunology / Issue 4/2024
Print ISSN: 0271-9142
Electronic ISSN: 1573-2592
DOI
https://doi.org/10.1007/s10875-024-01690-0

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Keynote webinar | Spotlight on medication adherence

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WHO estimates that half of all patients worldwide are non-adherent to their prescribed medication. The consequences of poor adherence can be catastrophic, on both the individual and population level.

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