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01-07-2016 | Original Article

Candidate gene variants of the immune system and sudden infant death syndrome

Authors: Delnaz Fard, Katharina Läer, Thomas Rothämel, Peter Schürmann, Matthias Arnold, Marta Cohen, Mechtild Vennemann, Heidi Pfeiffer, Thomas Bajanowski, Arne Pfeufer, Thilo Dörk, Michael Klintschar

Published in: International Journal of Legal Medicine | Issue 4/2016

Abstract

Background

Sudden infant death syndrome (SIDS) causes early infant death with an incidence between 0.5 and 2.5 cases among 1000 live births. Besides central sleep apnea and thermal dysregulation, infections have been repeatedly suggested to be implicated in SIDS etiology.

Methods

To test the risk contribution of common genetic variants related to infection, we genotyped 40 single-nucleotide polymorphisms (SNPs) from 15 candidate genes for association with SIDS in a total of 579 cases and 1124 controls from Germany and the UK in a two-stage case control design.

Results

The discovery-stage series (267 SIDS cases and 303 controls) revealed nominally significant associations for variants in interleukin 6 (IL6) (rs1880243), interleukin 10 (IL10) (rs1800871, rs1800872), and mannose-binding lectin 2 (MBL2) (rs930506), and for several other variants in subgroups. Meta-analyses were then performed in adding genotype information from a genome-wide association study of another 312 European SIDS cases and 821 controls. Overall associations were observed for two independent variants in MBL2: rs930506 in a co-dominant model (odds ratio (OR) = 0.82, p = 0.04) and rs1838065 in a dominant model (OR = 1.27, p = 0.03).

Conclusion

Our study did not replicate published associations of IL10 variants with SIDS. However, the evidence for two independent MBL2 variants in the combined analysis of two large series seems consistent with the hypothesis that infection may play a role in SIDS pathogenesis.

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Title: Candidate gene variants of the immune system and sudden infant death syndrome
Authors: Delnaz Fard
Katharina Läer
Thomas Rothämel
Peter Schürmann
Matthias Arnold
Marta Cohen
Mechtild Vennemann
Heidi Pfeiffer
Thomas Bajanowski
Arne Pfeufer
Thilo Dörk
Michael Klintschar
Publication date: 01-07-2016
Publisher: Springer Berlin Heidelberg
Published in: International Journal of Legal Medicine / Issue 4/2016
Print ISSN: 0937-9827
Electronic ISSN: 1437-1596
DOI: https://doi.org/10.1007/s00414-016-1347-y

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Candidate gene variants of the immune system and sudden infant death syndrome

Abstract

Background

Methods

Results

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Methods

Results

Conclusion

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