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Journal of Diabetes & Metabolic Disorders
Published in: Journal of Diabetes & Metabolic Disorders 1/2021

01-06-2021 | Candida Balanitis | Research article

Candida albicans skin infection in patients with type 2 diabetes: a systematic review and meta-analysis

Authors: Shna Rasoulpoor, Shamarina Shohaimi, Nader Salari, Aliakbar Vaisi-Raygani, Shabnam Rasoulpoor, Shervin Shabani, Rostam Jalali, Masoud Mohammadi

Published in: Journal of Diabetes & Metabolic Disorders | Issue 1/2021

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Abstract

Background

Fungal infections including Candida albicans is one of the most important health concerns among type 2 diabetic patients. Therefore, this study aimed to determine the prevalence of C. albicans skin infection in patients with type 2 diabetes in a systematic review and meta-analysis.

Methods

In this review study, data were extracted from national and international databases of SID, MagIran, IranMedex, IranDoc, Google Scholar, Cochrane, Embase, ScienceDirect, Scopus, PubMed, and Web of Science (WoS) with no time limit until January 2021. The random effects model was used for doing analysis and the I2 index was used for assessing the heterogeneity of studies. Data were analyzed using Comprehensive Meta-Analysis (Version 2).

Results

The prevalence of C. albicans skin infection in patients with type 2 diabetes was 11.4% (95% CI: 8.9%–14.4%) in 13 reviewed articles with a sample size of 1348. Regarding the heterogeneity based on meta-regression, there was a significant difference between the effect of sample size (P < 0.05) and the prevalence of C. albicans skin infection in patients with type 2 diabetes.

Conclusion

The results of this study showed that C. albicans skin infection was high in type 2 diabetic patients in Iran. Therefore, to improve the aforementioned situation and to troubleshoot and monitor at all levels, appropriate policies should be adopted.
Literature
1.
Habif TP. Vesicular and bullous diseases. Clinical dermatology 5th ed Edinburgh: Mosby Elsevier. 2009:635–70.
2.
Menon T, Umamaheswari K, Kumarasamy N, Solomon S, Thyagarajan S. Efficacy of fluconazole and itraconazole in the treatment of oral candidiasis in HIV patients. Acta Trop. 2001;80(2):151–4.CrossRef
3.
Motaleb-nejad M, Jafari S, Mirzaii M. Study of the relation of dentistry and mouth contamination with C. albicans. J Iranian Islamic Community of Dentists. 2005;18(1):37–42.
4.
Bunikowski R, Mielke ME, Skarabis H, Worm M, Anagnostopoulos I, Kolde G, et al. Evidence for a disease-promoting effect of Staphylococcus aureus–derived exotoxins in atopic dermatitis. J Allergy Clin Immunol. 2000;105(4):814–9.CrossRef
5.
Aguiree F, Brown A, Cho N, Dahlquist G, Aguiree B, Cho D, et al. Whiting (2013) IDF Diabetes Atlas. IDF Diabetes Atlas, 6th Edition, International Diabetes Federation, Basel.74–90.
6.
Association AD. 2. Classification and diagnosis of diabetes. Diabetes care. 2017;40(Supplement 1):S11-S24.
7.
Guariguata L. By the numbers: new estimates from the IDF diabetes atlas update for 2012. Diabetes Res Clin Pract. 2012;98(3):524–5.CrossRef
8.
Whiting DR, Guariguata L, Weil C, Shaw J. IDF diabetes atlas: global estimates of the prevalence of diabetes for 2011 and 2030. Diabetes Res Clin Pract. 2011;94(3):311–21.CrossRef
9.
Khazaei S, Rezaeian S, Nematollahi S. Relation between the prevalence of diabetes mellitus and human development index: a global ecological study. Health Scope. 2017;6(2):6.
10.
Boyle JP, Honeycutt AA, Narayan KV, Hoerger TJ, Geiss LS, Chen H, et al. Projection of diabetes burden through 2050: impact of changing demography and disease prevalence in the US. Diabetes Care. 2001;24(11):1936–40.CrossRef
11.
Larejani B, Zahedi F. Epidemiology of diabetes mellitus in Iran. Iranian Journal of Diabetes and Metabolism. 2001;1(1):1–8.
12.
Naheed T, Akbar N, Akbar N, Shehzad M, Jamil S, Ali T. Skin manifestations amongst diabetic patients admitted in a general medical ward for various other medical problems. Pakistan Journal of Medical Sciences. 2002;18(4):291–6.
13.
Bansal E, Garg A, Bhatia S, Attri A, Chander J. Spectrum of microbial flora in diabetic foot ulcers. Indian J Pathol Microbiol. 2008;51(2):204–8.CrossRef
14.
Abilash S, Kannan N, Rajan K, Pramodhini M, Ramanathan M. Clinical study on the prevalance of fungal infections in diabetic foot ulcers. International Journal of Current Research and Review. 2015;7(23):8.
15.
Fata S, Saeid MM, Feyzi R, Najafzadeh MJ, Afzal AM, Ghasemi M, et al. Mycotic infections in diabetic foot ulcers in Emam Reza hospital, Mashhad, 2006-2008. 2011.
16.
Kalshetti VT, Wadile R, Bothikar S, Ambade V, Bhate V. Study of fungal infections in diabetic foot ulcer. Indian J Microbiol Res. 2017;4(1):87–9.
17.
18.
Baloch GH, Memon NM, Devrajani BR, Iqbal P, Thebo NK. Cutaneous manifestations of type-II diabetes mellitus. J Liaquat Uni Med Health Sci. 2008;7(2):67–70.CrossRef
19.
Roudbary M, Razi F, Mohammadi SR, Annabestani Z, Nasli-Esfahani E. Pelagia Research Library. European Journal of Experimental Biology. 2014;4(4):20–5.
20.
Raiesi O, Siavash M, Mohammadi F, Chabavizadeh J, Mahaki B, Maherolnaghsh M, et al. Frequency of cutaneous fungal infections and azole resistance of the isolates in patients with diabetes mellitus. Advanced biomedical research. 2017;6.
21.
Rashidi T, Alamdari Mahd A, Dadvand A. C. albicans skin infection in diabetic patients. Journal of Ardabil University of Medical Sciences. 2008;8(3):250–5.
22.
Nithyalakshmi J, Nirupa S, Sumathi G. Diabetic foot ulcers and Candida co-infection: a single centered study. Int J Curr Microbiol App Sci. 2014;3(11):413–9.
23.
Lugo-Somolinos A, Sánchez JL. Prevalence of dermatophytosis in patients with diabetes. J Am Acad Dermatol. 1992;26(3):408–10.CrossRef
24.
Selvaraj J, Jeevaraman S, Shankar R. Prevalence of fungal infections among diabetic foot ulcer patients in a rural area in South India. 2016.
25.
Heald A, O'Halloran D, Richards K, Webb F, Jenkins S, Hollis S, et al. Fungal infection of the diabetic foot: two distinct syndromes. Diabet Med. 2001;18(7):567–72.CrossRef
26.
Khoharo HK, Ansari S, Qureshi F. Frequency of skin manifestations in 120 type 2 diabetics presenting at tertiary care hospital. JLUMHS. 2009;8(01):12.
27.
Wild S, Roglic G, Green A, Sicree R, King H. Global prevalence of diabetes: estimates for the year 2000 and projections for 2030. Diabetes Care. 2004;27(5):1047–53.CrossRef
28.
Stadelmann WK, Digenis AG, Tobin GR. Impediments to wound healing. American journal of surgery. 1998;176(2A Suppl):39s–47s.
29.
Heald AH, O'Halloran DJ, Richards K, Webb F, Jenkins S, Hollis S, et al. Fungal infection of the diabetic foot: two distinct syndromes. Diabetic medicine : a journal of the British Diabetic Association. 2001;18(7):567–72.CrossRef
30.
Farshchian M, Yazdan Far A, Farshchian M, Fereidoonnejad M. Relative frequency of cutaneous manifestations in diabetic patients referred to Hamadan Sina Hospital annals of military and health sciences research. 2007;5(3):1311–6.
31.
Darjani A, Attar Khataie A, Farrokhian K, Sobhani A, Kalantari S. Prevalence of skin lesions in diabetic patients. Journal of Guilan University of Medical Sciences. 2002;11(43):60–6.
32.
Phulari YJ, Kaushik V. Study of cutaneous manifestations of type 2 diabetes mellitus. Int J Res Dermatol. 2018;4(1):8–13.CrossRef
33.
Eke N. Fournier's gangrene: a review of 1726 cases. British Journal of Surgery. 2000;87(6):718-.
34.
Seneviratne C, Jin L, Samaranayake Y, Samaranayake L. Cell density and cell aging as factors modulating antifungal resistance of C. albicans biofilms. Antimicrob Agents Chemother. 2008;52(9):3259–66.CrossRef
35.
Pfaller M, Diekema D. Epidemiology of invasive candidiasis: a persistent public health problem. Clin Microbiol Rev. 2007;20(1):133–63.CrossRef
36.
Worth LJ, Blyth CC, Booth D, Kong DCM, Marriott D, Cassumbhoy M, et al. Optimizing antifungal drug dosing and monitoring to avoid toxicity and improve outcomes in patients with haematological disorders. Intern Med J. 2008;38(6b):521–37.CrossRef
37.
Chouhan S, Kallianpur S, Prabhu KT, Tijare M, Kasetty S, Gupta S. Candidal prevalence in diabetics and its species identification. Int J Appl Basic Med Res. 2019;9(1):49–54.PubMedPubMedCentral
38.
Rodrigues CF, Rodrigues ME, Henriques M. candida sp. Infections in Patients with Diabetes Mellitus. J Clin Med. 2019; 8(1): 76.
Metadata
Title
Candida albicans skin infection in patients with type 2 diabetes: a systematic review and meta-analysis
Authors
Shna Rasoulpoor
Shamarina Shohaimi
Nader Salari
Aliakbar Vaisi-Raygani
Shabnam Rasoulpoor
Shervin Shabani
Rostam Jalali
Masoud Mohammadi
Publication date
01-06-2021
Publisher
Springer International Publishing
Published in
Journal of Diabetes & Metabolic Disorders / Issue 1/2021
Electronic ISSN: 2251-6581
DOI
https://doi.org/10.1007/s40200-021-00797-0

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