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Open Access 01-12-2020 | Cancer Therapy | Research article

Clinical effects of curcumin in enhancing cancer therapy: A systematic review

Authors: Kamran Mansouri, Shna Rasoulpoor, Alireza Daneshkhah, Soroush Abolfathi, Nader Salari, Masoud Mohammadi, Shabnam Rasoulpoor, Shervin Shabani

Published in: BMC Cancer | Issue 1/2020

Abstract

Background

Curcumin is herbal compound that has been shown to have anti-cancer effects in pre-clinical and clinical studies. The anti-cancer effects of curcumin include inhibiting the carcinogenesis, inhibiting angiogenesis, and inhibiting tumour growth. This study aims to determine the Clinical effects of curcumin in different types of cancers using systematic review approach.

Methods

A systematic review methodology is adopted for undertaking detailed analysis of the effects of curcumin in cancer therapy. The results presented in this paper is an outcome of extracting the findings of the studies selected from the articles published in international databases including SID, MagIran, IranMedex, IranDoc, Google Scholar, ScienceDirect, Scopus, PubMed and Web of Science (ISI). These databases were thoroughly searched, and the relevant publications were selected based on the plausible keywords, in accordance with the study aims, as follows: prevalence, curcumin, clinical features, cancer.

Results

The results are derived based on several clinical studies on curcumin consumption with chemotherapy drugs, highlighting that curcumin increases the effectiveness of chemotherapy and radiotherapy which results in improving patient’s survival time, and increasing the expression of anti-metastatic proteins along with reducing their side effects.

Conclusion

The comprehensive systematic review presented in this paper confirms that curcumin reduces the side effects of chemotherapy or radiotherapy, resulting in improving patients’ quality of life. A number of studies reported that, curcumin has increased patient survival time and decreased tumor markers’ level.

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Title: Clinical effects of curcumin in enhancing cancer therapy: A systematic review
Authors: Kamran Mansouri
Shna Rasoulpoor
Alireza Daneshkhah
Soroush Abolfathi
Nader Salari
Masoud Mohammadi
Shabnam Rasoulpoor
Shervin Shabani
Publication date: 01-12-2020
Publisher: BioMed Central
Keyword: Cancer Therapy
Published in: BMC Cancer / Issue 1/2020
Electronic ISSN: 1471-2407
DOI: https://doi.org/10.1186/s12885-020-07256-8

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