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Medical Oncology
Published in: Medical Oncology 1/2011

01-03-2011 | Letter to the Editor

Cancer-specific methylation in the BRCA1 promoter in sporadic breast tumours

Authors: Azhar B. Ali, Philip T. C. Iau, Jen-Hwei Sng

Published in: Medical Oncology | Issue 1/2011

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Excerpt

To the Editor …
Literature
1.
Catteau A, Harris WH, Xu CF, et al. Methylation of the BRCA1 promoter region in sporadic breast and ovarian cancer: correlation with disease characteristics. Oncogene. 1999;18:1957–65.PubMedCrossRef
2.
Rice JC, Ozcelik H, Maxeiner P. Methylation of the BRCA1 promoter is associated with decreased BRCA1 mRNA levels in clinical breast cancer specimens. Carcinogenesis. 2000;21:1761–5.PubMedCrossRef
3.
Hedenfalk I, Duggan D, Chen Y. Gene-expression profiles in hereditary breast cancer. N Engl J Med. 2001;344:539–48.PubMedCrossRef
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van’t Veer LJ, Dai H, Vijver MJ, et al. Gene expression profiling predicts clinical outcome of breast cancer. Nature. 2002;415:530–6.CrossRef
5.
Rice JC, Massey-Brown KS, Futscher BW. Aberrant methylation of the BRCA1 CpG island promoter is associated with decreased BRCA1 mRNA in sporadic breast cancer cells. Oncogene. 1998;17:1807–12.PubMedCrossRef
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Xu CF, Chambers JA, Solomon E. Complex regulation of the BRCA1 gene. J Biol Chem. 1997;272:20994–7.PubMedCrossRef
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Brabender J, Usadel H, Metzger R, et al. DNA methyltransferase methylation analysis in curatively resected non-small cell lung cancer: associations with clinical outcome. Clin Cancer Res. 2003;9:223–7.PubMed
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Peters I, Rehmet K, Wilke N, et al. RASSF1A promoter methylation and expression analysis in normal and neoplastic kidney indicates a role in early tumorigenesis. Mol Cancer. 2007;16:49.CrossRef
10.
Snell C, Krypuy M, Wong EM, et al. BRCA1 promoter methylation in peripheral blood DNA of mutation negative familial breast cancer patients with a BRCA1 tumour phenotype. Breast Cancer Res. 2008;10:R12.PubMedCrossRef
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Malone CS, Miner MD, Doerr JR, et al. CmC(A/T)GG DNA methylation in mature B cell lymphoma gene silencing. Proc Natl Acad Sci USA. 2001;98:104040–10409.CrossRef
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Teng C, Gladwell W, Ralphiou I, et al. Methylation and expression of the lactoferrin gene in human tissues and cancer cells. Biometals. 2004;17:317–23.PubMedCrossRef
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Chan QKY, Khoo US, Chan KYK, et al. Promoter methylation and differential expression of π-class glutathione s-transferase in endometrial carcinoma. J Mol Diagn. 2005;7:8–16.PubMedCrossRef
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Ramsahoye BH, Biniszkiewicz D, Lyko F, et al. Non-CpG methylation is prevalent in embryonic stem cells and may be mediated by DNA methyltransferase 3a. Proc Natl Acad Sci USA. 2000;97:5237–42.PubMedCrossRef
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Grandjean V, Yaman R, Cuzin F. Inheritance of an epigenetic mark: the CpG DNA methyltransferase 1 is required for de novo establishment of a complex pattern of non-CpG methylation. PLoS ONE. 2007;2:e1136.PubMedCrossRef
Metadata
Title
Cancer-specific methylation in the BRCA1 promoter in sporadic breast tumours
Authors
Azhar B. Ali
Philip T. C. Iau
Jen-Hwei Sng
Publication date
01-03-2011
Publisher
Springer US
Published in
Medical Oncology / Issue 1/2011
Print ISSN: 1357-0560
Electronic ISSN: 1559-131X
DOI
https://doi.org/10.1007/s12032-010-9438-y

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Keynote webinar | Spotlight on medication adherence

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WHO estimates that half of all patients worldwide are non-adherent to their prescribed medication. The consequences of poor adherence can be catastrophic, on both the individual and population level.

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