Issue 3/2008
Content (23 Articles)
Effect of medical castration on CYP3A4 enzyme activity using the erythromycin breath test
Paul R. Hutson, Kurt Oettel, Jeff Douglas, Mark Ritter, Ed Messing, Mary Jane Staab, Dona Alberti, Dorthea Horvath, George Wilding
The effect of p53 gene expression on the inhibition of cell proliferation by paclitaxel
Fumio Sakashita, Shinji Osada, Masao Takemura, Hisashi Imai, Hiroyuki Tomita, Kenichi Nonaka, Takao Takahashi, Mitsuru Seishima
The plasma and cerebrospinal fluid pharmacokinetics of erlotinib and its active metabolite (OSI-420) after intravenous administration of erlotinib in non-human primates
Holly J. Meany, Elizabeth Fox, Cynthia McCully, Chris Tucker, Frank M. Balis
Topotecan and carboplatin in patients with platinum-sensitive recurrent ovarian cancer. Results of a multicenter NOGGO: phase I/II study
Dominique Koensgen, Dirk Stengel, Antje Belau, Peter Klare, Guelten Oskay-Oezcelik, Thomas Steck, Oumar Camara, Alexander Mustea, Harald Sommer, Alexandra Coumbos, Thomas Bogenrieder, Werner Lichtenegger, Jalid Sehouli
Relationship of peripheral blood CD4-positive T cells to carcinogenesis in patients with HCV-related chronic hepatitis and liver cirrhosis
Teppei Matsui, Hidenari Nagai, Yasukiyo Sumino, Kazumasa Miki
Combination of all-trans retinoic acid and interferon-gamma upregulated p27kip1 and down regulated CDK2 to cause cell cycle arrest leading to differentiation and apoptosis in human glioblastoma LN18 (PTEN-proficient) and U87MG (PTEN-deficient) cells
Ran Zhang, Naren L. Banik, Swapan K. Ray
Tumor, tissue, and plasma pharmacokinetic studies and antitumor response studies of docetaxel in combination with 9-nitrocamptothecin in mice bearing SKOV-3 human ovarian xenografts
William C. Zamboni, Sandra Strychor, Erin Joseph, Robert A. Parise, Merrill J. Egorin, Julie L. Eiseman
The first case of phenytoin intoxication associated with the concomitant use of phenytoin and TS-1, a combination preparation of tegafur, gimeracil, and oteracil potassium
Aiko Tsuda, Junshin Fujiyama, Akiko Miki, Satoko Hori, Hisakazu Ohtani, Yasufumi Sawada
Plasma and cerebrospinal fluid pharmacokinetics of the histone deacetylase inhibitor, belinostat (PXD101), in non-human primates
Katherine E. Warren, Cindy McCully, Henrik Dvinge, Jette Tjørnelund, Maxwell Sehested, Henri S. Lichenstein, Frank M. Balis
The FLT3 inhibitor PKC412 in combination with cytostatic drugs in vitro in acute myeloid leukemia
Lars Möllgård, Stefan Deneberg, Hareth Nahi, Sofia Bengtzen, Kerstin Jonsson-Videsäter, Thoas Fioretos, Anna Andersson, Christer Paul, Sören Lehmann
A dose escalation and pharmacokinetic study of biweekly pegylated liposomal doxorubicin, paclitaxel and oxaliplatin in patients with advanced solid tumors
Kostas Kalbakis, Periklis Pappas, Charalambos Kouroussis, Lambros Vamvakas, Antonia Kalykaki, Nikolaos Vardakis, Martha Nikolaidou, Marios Marselos, Vassilis Georgoulias, Dimitris Mavroudis
Plasma pharmacokinetics and oral bioavailability of 3,4,5,6-tetrahydrouridine, a cytidine deaminase inhibitor, in mice
Jan H. Beumer, Julie L. Eiseman, Robert A. Parise, Jeffry A. Florian Jr., Erin Joseph, David Z. D’Argenio, Robert S. Parker, Brittany Kay, Joseph M. Covey, Merrill J. Egorin
Phase II study of nedaplatin and irinotecan followed by gefitinib for elderly patients with unresectable non-small cell lung cancer
Fumihiro Oshita, Kouzo Yamada, Haruhiro Saito, Kazumasa Noda
Formaldehyde-releasing prodrugs specifically affect cancer cells by depletion of intracellular glutathione and augmentation of reactive oxygen species
Inesa Levovich, Abraham Nudelman, Gili Berkovitch, Lonnie P. Swift, Suzanne M. Cutts, Don R. Phillips, Ada Rephaeli
In vitro evaluation of the growth inhibition and apoptosis effect of mifepristone (RU486) in human Ishikawa and HEC1A endometrial cancer cell lines
Marisa A. Navo, Judith A. Smith, Anjali Gaikwad, Thomas Burke, Jubilee Brown, Lois M. Ramondetta
Two peptides derived from ras-p21 induce either phenotypic reversion or tumor cell necrosis of ras-transformed human cancer cells
Victor Adler, Wilbur Bowne, Ikram Kamran, Josef Michl, Fred K. Friedman, Edwin Chin, Michael Zenilman, Matthew R. Pincus
A Phase I and pharmacokinetic study of selenomethionine in combination with a fixed dose of irinotecan in solid tumors
Marwan G. Fakih, Lakshmi Pendyala, William Brady, Patrick F. Smith, Mary E. Ross, Patrick J. Creaven, Vladimir Badmaev, Joshua D. Prey, Youcef M. Rustum
4-Aryl-1,3,2-oxathiazolylium-5-olate: a novel GST inhibitor to release JNK and activate c-Jun for cancer therapy
Huifei Cui, Jie Shen, Dongning Lu, Tao Zhang, Wenpeng Zhang, Duxin Sun, Peng George Wang
Polyamine catabolism in colorectal cancer cells following treatment with oxaliplatin, 5-fluorouracil and N 1 , N 11 diethylnorspermine
Suzanne Hector, Ramakumar Tummala, Nicholas D. Kisiel, Paula Diegelman, Slavoljub Vujcic, Kimberly Clark, Marwan Fakih, Debora L. Kramer, Carl W. Porter, Lakshmi Pendyala
Impact of CYP3A4 haplotypes on irinotecan pharmacokinetics in Japanese cancer patients
Kimie Sai, Yoshiro Saito, Hiromi Fukushima-Uesaka, Koichi Kurose, Nahoko Kaniwa, Naoyuki Kamatani, Kuniaki Shirao, Noboru Yamamoto, Tetsuya Hamaguchi, Hideo Kunitoh, Yuichiro Ohe, Tomohide Tamura, Yasuhide Yamada, Hironobu Minami, Atsushi Ohtsu, Teruhiko Yoshida, Nagahiro Saijo, Jun-ichi Sawada
Phase II study of capecitabine and cisplatin combination as first-line chemotherapy in Chinese patients with metastatic nasopharyngeal carcinoma
Yu-Hong Li, Feng-Hua Wang, Wen-Qi Jiang, Xiao-Juan Xiang, Yan-Ming Deng, Guo-Qing Hu, De-Ming Xu, Yan Chen, Qing Lin, You-Jian He
Influence of carboplatin infusion on osteosarcoma blood flow
Gene R. DiResta, Sean W. Aiken, Holly K. Brown, Philip J. Bergman, Ann Hohenhaus, John H. Healey
Logistic regression analysis for febrile neutropenia (FN) induced by docetaxel in Japanese cancer patients
Kazuhiro Ozawa, Hironobu Minami, Hitoshi Sato