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Pediatric Surgery International

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01-03-2020 | Cancer Biomarker | Original Article

The role of preoperative imaging and tumor markers in predicting malignant ovarian masses in children

Authors: Guogang Ye, Ting Xu, Jiangbin Liu, Weijue Xu, Zhibao Lv

Published in: Pediatric Surgery International | Issue 3/2020

Abstract

Purpose

To investigate the clinicopathololgic characteristics and the predicting value of preoperative imaging and tumor markers in children with ovarian masses.

Methods

Patients admitted in Shanghai children’s hospital with ovary neoplasms between 2010.01 and 2015.12 were retrospectively analyzed. The medical records including age at operation, presentation of symptoms and signs, tumor marker, imaging, pathology, tumor diameter and surgical choice were reviewed. All data were analyzed using SPSS 17.0

Results

A total of 139 patients were included, among which 116 were benign neoplasms and 23 malignant tumors. There was significance difference relation with the tumor diameter, character, torsion and tumor markers, but not the age, position, calculi, and symptoms. The risk factors include tumor diameters ≥ 10 cm, the odds ratio (OR) was 11, 95% confidence interval (CI) was 3–36, solid/complex tumor (OR 6, 95% CI 2, 14) and positive in tumor markers (OR 84, 95% CI 20, 345). Among the patients with benign neoplasms, 77 of them had laparoscopic ovarian cystectomy while 23 patients with malignant tumors had salpingo-oophorectomy and omentum resection.

Conclusion

Preoperative imaging and tumor markers could help identifying the malignant ovarian masses in children. If tumor diameter ≥ 10 cm, solid/complex in imaging and tumor markers abnormal, a radical resection is mandatory; otherwise, an ovarian-sparing surgery is recommended.

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Title: The role of preoperative imaging and tumor markers in predicting malignant ovarian masses in children
Authors: Guogang Ye
Ting Xu
Jiangbin Liu
Weijue Xu
Zhibao Lv
Publication date: 01-03-2020
Publisher: Springer Berlin Heidelberg
Keyword: Cancer Biomarker
Published in: Pediatric Surgery International / Issue 3/2020
Print ISSN: 0179-0358
Electronic ISSN: 1437-9813
DOI: https://doi.org/10.1007/s00383-019-04591-1

At a glance: The STEP trials

Springer Medicine

The role of preoperative imaging and tumor markers in predicting malignant ovarian masses in children

Abstract

Purpose

Methods

Results

Conclusion

At a glance: The STEP trials

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusion

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