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Open Access 01-12-2012 | Research

Can exhaled NO fraction predict radiotherapy-induced lung toxicity in lung cancer patients?

Authors: Irina Enache, Georges Noel, M-Young Jeung, Nicolas Meyer, Monique Oswald-Mammosser, Emile Urban-Kraemer, Catherine Schumacher, Bernard Geny, Elisabeth Quoix, Anne Charloux

Published in: Radiation Oncology | Issue 1/2012

Abstract

Background

A large increase in nitric oxide fraction (FeNO) after radiotherapy (RT) for lung cancer may predict RT-induced lung toxicity.

Methods

In this study, we assessed the relationships between FeNO variations and respiratory symptoms, CT scan changes or dose volume histogram (DVH) parameters after RT. We measured FeNO before RT, 4, 5, 6, 10 weeks, 4 and 7.5 months after RT in 65 lung cancer patients.

Results

Eleven lung cancer patients (17%) complained of significant respiratory symptoms and 21 (31%) had radiation pneumonitis images in >1/3 of the irradiated lung after RT. Thirteen patients (20%) showed increases in FeNO >10 ppb. The sensitivity and specificity of a >10 ppb FeNO increase for the diagnosis of RT-associated respiratory symptoms were 18% and 83%, respectively. There was no correlation between DVH parameters or CT scan changes after RT and FeNO variations. Three patients (5%) showed intriguingly strong (2 or 3-fold, up to 55 ppb) and sustained increases in FeNO at 4 and 5 weeks, followed by significant respiratory symptoms and/or radiation-pneumonitis images.

Conclusion

Serial FeNO measurements during RT had a low ability to identify lung cancer patients who developed symptoms or images of radiation pneumonitis. However, three patients presented with a particular pattern which deserves to be investigated.

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Title: Can exhaled NO fraction predict radiotherapy-induced lung toxicity in lung cancer patients?
Authors: Irina Enache
Georges Noel
M-Young Jeung
Nicolas Meyer
Monique Oswald-Mammosser
Emile Urban-Kraemer
Catherine Schumacher
Bernard Geny
Elisabeth Quoix
Anne Charloux
Publication date: 01-12-2012
Publisher: BioMed Central
Published in: Radiation Oncology / Issue 1/2012
Electronic ISSN: 1748-717X
DOI: https://doi.org/10.1186/1748-717X-7-117

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Can exhaled NO fraction predict radiotherapy-induced lung toxicity in lung cancer patients?

Abstract

Background

Methods

Results

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Methods

Results

Conclusion

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