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Journal of Nephrology
Published in: Journal of Nephrology 1/2021

01-02-2021 | Calcimimetic | Editorial

Dialysate calcium concentration during calcimimetic treatment: a neglected issue

Authors: Francesco Locatelli, Silverio Rotondi, Lucia Del Vecchio, Sandro Mazzaferro

Published in: Journal of Nephrology | Issue 1/2021

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Excerpt

Hypocalcaemia is a well-known effect of the treatment of secondary hyperparathyroidism when using calcimimetics. …
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Kidney Disease: Improving Global Outcomes (KDIGO) CKD-MBD Update Work Group (2017) KDIGO 2017 clinical practice guideline update for the diagnosis, evaluation, prevention, and treatment of chronic kidney disease-mineral and bone disorder (CKD-MBD). Kidney Int Suppl 7:1–59CrossRef
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Gotch FA (2009) Pro/Con debate: the calculation on calcium balance in dialysis lowers the dialysate calcium concentrations (pro part). Nephrol Dial Transplant 24:2994–2996CrossRef
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Drüeke TB, Touam M (2009) Calcium balance in haemodialysis-do not lower thedialysate calcium concentration too much (con part). Nephrol Dial Transplant 24:2990–2993CrossRef
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Evaluation of Cinacalcet HCl Therapy to Lower Cardiovascular Events (EVOLVE) Trial Investigators, Moe SM, Chertow GM, Parfrey PS et al (2015) Cinacalcet, fibroblast growth factor-23, and cardiovascular disease in hemodialysis: the Evaluation of Cinacalcet HCl Therapy to Lower Cardiovascular Events (EVOLVE) Trial. Circulation 132(1):27–39CrossRef
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Ok E, Asci G, Bayraktaroglu S et al (2016) Reduction of dialysate calcium level reduces progression of coronary artery calcification and improves low bone turnover in patients on hemodialysis. J Am Soc Nephrol 27(8):2475–2486CrossRef
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Gotch FA, Kotanko P, Thijssen S, Levin NW (2010) The KDIGO guideline for dialysate calcium will result in an increased incidence of calcium accumulation in hemodialysis patients. Kidney Int 201078(4):343–350CrossRef
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Argiles A, Mion CM (1996) Low-calcium dialysate worsens secondary hyperparathyroidism. J Am Soc Nephrol 7:635–636PubMed
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Argiles A (1995) Points to remember when selecting dialysate calcium concentration. Nephrol Dial Transplant 10:451–454CrossRef
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Di Filippo S, Carfagna F, La Milia V et al (2018) Assessment of intradialysis calcium mass balance by a single pool variable-volume calcium kinetic model. Hemodial Int 22(1):126–135CrossRef
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Gotch F, Kotanko P, Handelman G, Levin N (2007) A kinetic model of calcium mass balance during dialysis therapy. Blood Purif 25:139–149CrossRef
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Metadata
Title
Dialysate calcium concentration during calcimimetic treatment: a neglected issue
Authors
Francesco Locatelli
Silverio Rotondi
Lucia Del Vecchio
Sandro Mazzaferro
Publication date
01-02-2021
Publisher
Springer International Publishing
Keyword
Calcimimetic
Published in
Journal of Nephrology / Issue 1/2021
Print ISSN: 1121-8428
Electronic ISSN: 1724-6059
DOI
https://doi.org/10.1007/s40620-020-00741-0

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