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Current Atherosclerosis Reports
Published in: Current Atherosclerosis Reports 10/2013

01-10-2013 | Nutrition (BV Howard, Section Editor)

Cadmium Exposure and Clinical Cardiovascular Disease: A Systematic Review

Authors: Maria Tellez-Plaza, Miranda R. Jones, Alejandro Dominguez-Lucas, Eliseo Guallar, Ana Navas-Acien

Published in: Current Atherosclerosis Reports | Issue 10/2013

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Abstract

Mounting evidence supports that cadmium, a toxic metal found in tobacco, air and food, is a cardiovascular risk factor. Our objective was to conduct a systematic review of epidemiologic studies evaluating the association between cadmium exposure and cardiovascular disease. Twelve studies were identified. Overall, the pooled relative risks (95 % confidence interval) for cardiovascular disease, coronary heart disease, stroke, and peripheral arterial disease were: 1.36 (95 % CI: 1.11, 1.66), 1.30 (95 % CI: 1.12, 1.52), 1.18 (95 % CI: 0.86, 1.59), and 1.49 (95 % CI: 1.15, 1.92), respectively. The pooled relative risks for cardiovascular disease in men, women and never smokers were 1.29 (1.12, 1.48), 1.20 (0.92, 1.56) and 1.27 (0.97, 1.67), respectively. Together with experimental evidence, our review supports the association between cadmium exposure and cardiovascular disease, especially for coronary heart disease. The number of studies with stroke, heart failure (HF) and peripheral arterial disease (PAD) endpoints was small. More studies, especially studies evaluating incident endpoints, are needed.
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Metadata
Title
Cadmium Exposure and Clinical Cardiovascular Disease: A Systematic Review
Authors
Maria Tellez-Plaza
Miranda R. Jones
Alejandro Dominguez-Lucas
Eliseo Guallar
Ana Navas-Acien
Publication date
01-10-2013
Publisher
Springer US
Published in
Current Atherosclerosis Reports / Issue 10/2013
Print ISSN: 1523-3804
Electronic ISSN: 1534-6242
DOI
https://doi.org/10.1007/s11883-013-0356-2

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