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BMC Pulmonary Medicine

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Open Access 01-12-2024 | Bronchoscopy | Research

Treatment of malignant airway obstruction with Y-shape sigma stent loaded with I¹²⁵ seeds installed via rigid bronchoscopy

Authors: Chunlong Lin, Hesong Huang, Lixia Song, Xixi Zhao, Jialing Zeng, Lun Li, Qilong Ge, Rui Li, Zhiyuan Wu

Published in: BMC Pulmonary Medicine | Issue 1/2024

Abstract

Purpose

To summarize and analyze the safety and efficacy of a Y-shape Sigma stent loaded with I¹²⁵ in patients with inoperable malignant main airway obstruction.

Methods

This study was approved by the Institutional Ethics Committee, and a written informed consent was obtained from each participant. A Y-shape Sigma stent loaded with I¹²⁵ was placed under vision from rigid bronchoscopy. The primary endpoint was alleviation of symptoms and improvement of Karnofsky Performance Status (KPS) score, and the secondary endpoint was complications and technical success.

Results

From November 2018 through June 2023, total 33 patients with malignant airway obstruction were palliatively treated by installing Y-shape Sigma stents loaded with I¹²⁵. The airway lumen was immediately restored and the average airway opening significantly increased to 70 ± 9.4% after the procedure from baseline 30.2 ± 10.5% (p < 0.05). Average KPS score was improved from baseline 30.0 ± 10.0 to 70.0 ± 10.0 (p < 0.05) as well as PaO₂ from baseline 50.1 ± 15.4 mmHg to 89.3 ± 8.6 mmHg (p < 0.05). The technical success rate of placing the stent in this study was 73%, and adverse events or complications including bleeding, I¹²⁵ loss, and airway infection occurred during or after the procedure.

Conclusion

Placement of Y-shape Sigma stents under vision from rigid bronchoscopy in the patients with malignant airway obstruction is feasible and it immediately alleviates dyspnea and significantly improves quality of life.

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Title: Treatment of malignant airway obstruction with Y-shape sigma stent loaded with I125 seeds installed via rigid bronchoscopy
Authors: Chunlong Lin
Hesong Huang
Lixia Song
Xixi Zhao
Jialing Zeng
Lun Li
Qilong Ge
Rui Li
Zhiyuan Wu
Publication date: 01-12-2024
Publisher: BioMed Central
Keywords: Bronchoscopy
Lung Cancer
Lung Cancer
Lung Cancer
Brachytherapy
Published in: BMC Pulmonary Medicine / Issue 1/2024
Electronic ISSN: 1471-2466
DOI: https://doi.org/10.1186/s12890-024-03012-x

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