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BMC Cancer
Published in: BMC Cancer 1/2020

Open Access 01-12-2020 | Bronchoscopy | Research article

Value of oesophagoscopy and bronchoscopy in diagnosis of synchronous malignancies in patients with head and neck squamous cell carcinomas

Authors: Shi Yeung Ho, Raymond King Yin Tsang

Published in: BMC Cancer | Issue 1/2020

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Abstract

Background

Routine screening of patients with head and neck squamous cell carcinomas (HNSCCs) for synchronous malignancies using oesophagoscopy and bronchoscopy had been controversial. The aim of this study is therefore to find out the rate of synchronous malignancies in patients with primary HNSCCs, the risk factors for its occurrence and the effectiveness of oesophagoscopy and bronchoscopy from a 10-year experience in a single centre.

Methods

A retrospective review of medical records was conducted from July 2008 to June 2018 in a tertiary referral centre in Hong Kong. All patients with newly diagnosed HNSCCs were screened with oesophagoscopy and bronchoscopy at the time of diagnosis and therefore all patients were included in the study. The incidence of synchronous malignancies along the aerodigestive tract and the yield of oesophagoscopy and bronchoscopy were studied.

Results

Of the 702 patients included in the study, the overall rate of synchronous malignancies was 8.3% (58/702), with the rate of synchronous oesophageal and lung malignancies being 5.8% (41/702) and 0.85% (6/702) respectively. Fourteen out of the 41 oesophageal malignancies were only detectable with oesophagoscopy. Only one of the synchronous lung malignancies was detectable by bronchoscopy. Risk factors for synchronous malignancies include male gender, smokers, drinkers and primary hypopharyngeal cancer.

Conclusions

Oesophagoscopy is essential for detecting synchronous oesophageal malignancies in patients with HNSCCs especially in male patients, smokers and drinkers, and it is most valuable in primary hypopharyngeal cancer patients among all primary subsites. Bronchoscopy had a low yield for synchronous lung malignancies and can be potentially replaced by imaging techniques.
Literature
1.
Billroth T, Von Winiwarter A. A general surgical pathology and therapeutics. New York: Appleton; 1883.
2.
Slaughter DP, Southwick HW, Smejkal W. Field cancerization in oral stratified squamous epithelium; clinical implications of multicentric origin. Cancer. 1953:963–8.
3.
Bhattacharyya N, Nayak JK. Survival outcomes for second primary head and neck cancer: a matched analysis. Otolaryngol Head Neck Surg. 2005;132:63–8.CrossRef
4.
Schwarz LH, Ozsahin M, Zhang GN, et al. Synchronous and metachronous head and neck carcinoma. Cancer. 1994;74:1933–8.CrossRef
5.
Di Martino E, Sellhaus B, Hausmann R, et al. Survival in sec-ond primary malignancies of patients with head and neck cancer. J Laryngol Otol. 2002;116:831–8.CrossRef
6.
Chung CS, Liao LJ, Lo WC, et al. Risk factors for second primary neoplasia of oesophagus in newly diagnosed head and neck cancer patients. BMC Gastroenterol. 2013;13:154.CrossRef
7.
McGuirt WF. Panendoscopy as a screening examination for synchronous primary cancers in head and neck cancer: a prospective sequential study and review of the literature. Laryngoscope. 1982;92:569–76.CrossRef
8.
Maisel RH, Vermeersch H. Panendoscopy for second primaries in head and neck cancer. Ann Otol Rhinol Laryngol. 1981;90:460–4.CrossRef
9.
Abemayor E, Moore DM, Hanson DG. Identification of synchronous oesophageal cancers in patients with head and neck cancer. J Surg Oncol. 1988;38:94–6.CrossRef
10.
Colt HG, Matsuo T. Hospital charges attributable to bronchoscopy-related complications in outpatients. Respiration. 2001;68:67–72.CrossRef
11.
Ginzburg L, Greenwald D. Cohen J/ complications of endoscopy. Gastrointest Endosc Clin N Am. 2007;17:405–32.CrossRef
12.
Soni A, Sampliner RE, Sonnenberg A. Screening for high-grade dysplasia in gastrooesophageal reflux disease: is it cost- effective? Am J Gastroenterol. 2000;95:2086–93.CrossRef
13.
Gupta N, Bansal A, Wani SB, Gaddam S, Rastogi A, Sharma P. Endoscopy for upper GI cancer screening in the general population: a cost-utility analysis. Gastrointest Endosc. 2011;74:610–24.CrossRef
14.
McGarey PO, O’Rourke AK, Owen SR, et al. Rigid Oesophagoscopy for head and neck Cancer staging and the incidence of synchronous Oesophageal malignant neoplasms. JAMA Otolaryngol Head Neck Surg. 2016;142(1):40–5.CrossRef
15.
Chow TL, Lee DT, Choi CY, Chan TT, Lam SH. Prediction of synchronous oesophageal lesions in head and neck squamous cell carcinoma: a multivariate analysis. Arch Otolaryngol Head Neck Surg. 2009;135:882–5.CrossRef
16.
Huang YC, Lee YC, Tseng PH, et al. Regular screening of oesophageal cancer for 248 newly diagnosed hypopharyngeal squamous cell carcinoma by unsedated transnasal esophagogastroduodenoscopy. Oral Oncol. 2016;55:55–60.CrossRef
17.
Zhang H-Z, Jin G-F, Shen H-B. Epidemiologic differences in oesophageal cancer between Asian and Western populations. Chin J Cancer. 2012;31(6):281–6.CrossRef
18.
Hung SH, Tsai MC, Liu TC, Lin HC, Chung SD. Routine endoscopy for esophageal cancer is suggestive for patients with oral, oropharyngeal and hypopharyngeal cancer. PLoS One. 2013;8(8):e72097.CrossRef
19.
Chuang SC, et al. Risk of second primary cancer among patients with head and neck cancers: a pooled analysis of 13cancer registries. Int J Cancer. 2008;123(10):2390–6.CrossRef
20.
Stoeckli SJ, Zimmermann R, Schmid S. Role of routine panendoscopy in cancer of the upper aerodigestive tract. Otolaryngol Head Neck Surg. 2001;124:208–12.CrossRef
21.
Guardiola E, Chaigneau L. VillanuevaC, PivotX. Is there still a role for triple endoscopy as part of staging for head and neck cancer? Curr Opin Otolaryngol Head Neck Surg. 2006;14(2):85–8.PubMed
22.
de Monès E, Bertolus C, Salaun PY, Dubrulle F, Ferrié JC, Temam S, Chevalier D, Vergez S, Lagarde F, Schultz P, Lapeyre M, Barry B, Tronche S, de Raucourt D, Morinière S. Initial staging of squamous cell carcinoma of the oral cavity, larynx and pharynx (excluding nasopharynx). Part 2: remote extension assessment and exploration for secondary synchronous locations outside of the upper aerodigestive tract. 2012 SFORL guidelines. Eur Ann Otorhinolaryngol Head Neck Dis. 2013;130:107–12.CrossRef
23.
Koo K, Harris R, Wiesenfeld D, Iseli TA. A role for panendoscopy? Second primary tumour in early stage squamous cell carcinoma of the oral tongue. J Laryngol Otol. 2015;129(S1):S27–31.CrossRef
24.
Rodriguez-Bruno K, Ali MJ, Wang SJ. Role of panendoscopy to identify synchronous second primary malignancies in patients with oral cavity and oropharyngeal squamous cell carcinoma. Head Neck. 2011;33:949–53.CrossRef
25.
Boiselle PM. Computed tomography screening for lung cancer. JAMA. 2013;309:1163–70.CrossRef
Metadata
Title
Value of oesophagoscopy and bronchoscopy in diagnosis of synchronous malignancies in patients with head and neck squamous cell carcinomas
Authors
Shi Yeung Ho
Raymond King Yin Tsang
Publication date
01-12-2020
Publisher
BioMed Central
Published in
BMC Cancer / Issue 1/2020
Electronic ISSN: 1471-2407
DOI
https://doi.org/10.1186/s12885-020-07681-9

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