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BMC Cancer
Published in: BMC Cancer 1/2020

01-12-2020 | Mood Disorders | Research article

Differential associations of proinflammatory and anti-inflammatory cytokines with depression severity from noncancer status to breast cancer course and subsequent chemotherapy

Authors: Bor-Show Tzang, Vincent Chin-Hung Chen, Ching-Chuan Hsieh, Wen-Ke Wang, Yi-Ping Weng, Hsing-Ying Ho, Ya-Ting Hsu, Han-Pin Hsaio, Jun-Cheng Weng, Yi-Lung Chen

Published in: BMC Cancer | Issue 1/2020

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Abstract

Background

In this study, we examined the differential associations of various proinflammatory and anti-inflammatory cytokines with depression severity from the development of breast cancer to subsequent chemotherapy treatment.

Methods

A cross-sectional study was conducted on a sample of 116 women: 29 controls without cancer, 55 patients with breast cancer who were not receiving chemotherapy, and 32 patients with breast cancer who were receiving chemotherapy. Blood samples were assayed to evaluate serum levels of the following cytokines: interferon-γ, interleukin (IL)-12 (p70), IL-1β, IL-2, tumor necrosis factor (TNF)-α, IL-4, IL-5, IL-10, IL-13, IL-6, and IL-17A. Depression severity was assessed using the Patient Health Questionnaire.

Results

After adjustment for sociodemographics, consistent patterns of the association between cytokine and depression were noted in the different groups. No significant associations were observed in the controls. Inverse associations were observed between cytokines levels and depression severity in patients with breast cancer who were not receiving chemotherapy, whereas positive associations were noted in patients with breast cancer who were receiving chemotherapy. Specific differential relationships between IL-5 levels and depression severity were found between patients with breast cancer who were receiving and not receiving chemotherapy.

Conclusions

Our study revealed differential relationships between cytokine levels and depression severity with the development of cancer. Immunostimulation and immunosuppression in breast cancer and cancer treatment may account for the differential responses with the development of breast cancer.
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Metadata
Title
Differential associations of proinflammatory and anti-inflammatory cytokines with depression severity from noncancer status to breast cancer course and subsequent chemotherapy
Authors
Bor-Show Tzang
Vincent Chin-Hung Chen
Ching-Chuan Hsieh
Wen-Ke Wang
Yi-Ping Weng
Hsing-Ying Ho
Ya-Ting Hsu
Han-Pin Hsaio
Jun-Cheng Weng
Yi-Lung Chen
Publication date
01-12-2020
Publisher
BioMed Central
Published in
BMC Cancer / Issue 1/2020
Electronic ISSN: 1471-2407
DOI
https://doi.org/10.1186/s12885-020-07181-w

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