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Current Allergy and Asthma Reports
Published in: Current Allergy and Asthma Reports 1/2020

01-01-2020 | Bronchial Asthma | Basic and Applied Science (I Lewkowich, Section Editor)

Circadian Rhythms in Immunity

Author: Stephen N. Waggoner

Published in: Current Allergy and Asthma Reports | Issue 1/2020

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Abstract

Purpose of Review

This review is focused on the existing evidence for circadian control of innate and adaptive immune responses to provide a framework for evaluating the contributions of diurnal rhythms to control of infections and pathogenesis of disease.

Recent Findings

Circadian rhythms driven by cell-autonomous biological clocks are central to innate and adaptive immune responses against microbial pathogens. Research during the past few years has uncovered circadian circuits governing leukocyte migration between tissues, the magnitude of mucosal inflammation, the types of cytokines produced, and the severity of immune diseases. Other studies revealed how disruption of the circadian clock impairs immune function or how microbial products alter clock machinery.

Summary

Revelations concerning the widespread impact of the circadian clock on immunity and homeostasis highlight how the timing of inflammatory challenges can dictate pathological outcomes and how the timing of therapeutic interventions likely determines clinical efficacy. An improved understanding of circadian circuits controlling immune function will facilitate advances in circadian immunotherapy.
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Metadata
Title
Circadian Rhythms in Immunity
Author
Stephen N. Waggoner
Publication date
01-01-2020
Publisher
Springer US
Published in
Current Allergy and Asthma Reports / Issue 1/2020
Print ISSN: 1529-7322
Electronic ISSN: 1534-6315
DOI
https://doi.org/10.1007/s11882-020-0896-9