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BMC Medical Informatics and Decision Making

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01-12-2020 | Bronchial Asthma | Software

FHIR PIT: an open software application for spatiotemporal integration of clinical data and environmental exposures data

Authors: Hao Xu, Steven Cox, Lisa Stillwell, Emily Pfaff, James Champion, Stanley C. Ahalt, Karamarie Fecho

Published in: BMC Medical Informatics and Decision Making | Issue 1/2020

Abstract

Background

Informatics tools to support the integration and subsequent interrogation of spatiotemporal data such as clinical data and environmental exposures data are lacking. Such tools are needed to support research in environmental health and any biomedical field that is challenged by the need for integrated spatiotemporal data to examine individual-level determinants of health and disease.

Results

We have developed an open-source software application—FHIR PIT (Health Level 7 Fast Healthcare Interoperability Resources Patient data Integration Tool)—to enable studies on the impact of individual-level environmental exposures on health and disease. FHIR PIT was motivated by the need to integrate patient data derived from our institution’s clinical warehouse with a variety of public data sources on environmental exposures and then openly expose the data via ICEES (Integrated Clinical and Environmental Exposures Service). FHIR PIT consists of transformation steps or building blocks that can be chained together to form a transformation and integration workflow. Several transformation steps are generic and thus can be reused. As such, new types of data can be incorporated into the modular FHIR PIT pipeline by simply reusing generic steps or adding new ones. We validated FHIR PIT in the context of a driving use case designed to investigate the impact of airborne pollutant exposures on asthma. Specifically, we replicated published findings demonstrating racial disparities in the impact of airborne pollutants on asthma exacerbations.

Conclusions

While FHIR PIT was developed to support our driving use case on asthma, the software can be used to integrate any type and number of spatiotemporal data sources at a level of granularity that enables individual-level study. We expect FHIR PIT to facilitate research in environmental health and numerous other biomedical disciplines.

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Title: FHIR PIT: an open software application for spatiotemporal integration of clinical data and environmental exposures data
Authors: Hao Xu
Steven Cox
Lisa Stillwell
Emily Pfaff
James Champion
Stanley C. Ahalt
Karamarie Fecho
Publication date: 01-12-2020
Publisher: BioMed Central
Keywords: Bronchial Asthma
Environmental Medicine
Published in: BMC Medical Informatics and Decision Making / Issue 1/2020
Electronic ISSN: 1472-6947
DOI: https://doi.org/10.1186/s12911-020-1056-9

At a glance: The STEP trials

Springer Medicine

FHIR PIT: an open software application for spatiotemporal integration of clinical data and environmental exposures data

Abstract

Background

Results

Conclusions

At a glance: The STEP trials

Springer Medicine

Abstract

Background

Results

Conclusions

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