Sole adjuvant intraoperative breast radiotherapy in Taiwan: a single-center experience

go back to reference Darby S, McGale P, Correa C, Taylor C, Arriagada R, Clarke M, Cutter D, Davies C, Ewertz M, Godwin J, et al. Effect of radiotherapy after breast-conserving surgery on 10-year recurrence and 15-year breast cancer death: meta-analysis of individual patient data for 10,801 women in 17 randomised trials. Lancet. 2011;378(9804):1707–16. https://doi.org/10.1016/S0140-6736(11)61629-2.CrossRefPubMed Darby S, McGale P, Correa C, Taylor C, Arriagada R, Clarke M, Cutter D, Davies C, Ewertz M, Godwin J, et al. Effect of radiotherapy after breast-conserving surgery on 10-year recurrence and 15-year breast cancer death: meta-analysis of individual patient data for 10,801 women in 17 randomised trials. Lancet. 2011;378(9804):1707–16. https://​doi.​org/​10.​1016/​S0140-6736(11)61629-2.CrossRefPubMed

go back to reference Korzets Y, Fyles A, Shepshelovich D, Amir E, Goldvaser H. Toxicity and clinical outcomes of partial breast irradiation compared to whole breast irradiation for early-stage breast cancer: a systematic review and meta-analysis. Breast Cancer Res Treat. 2019;175(3):531–45. https://doi.org/10.1007/s10549-019-05209-9.CrossRefPubMed Korzets Y, Fyles A, Shepshelovich D, Amir E, Goldvaser H. Toxicity and clinical outcomes of partial breast irradiation compared to whole breast irradiation for early-stage breast cancer: a systematic review and meta-analysis. Breast Cancer Res Treat. 2019;175(3):531–45. https://​doi.​org/​10.​1007/​s10549-019-05209-9.CrossRefPubMed

go back to reference Harris EER, Small W Jr. Intraoperative radiotherapy for breast cancer. Front Oncol. 2017;7:317. https://doi.org/10.3389/fonc.2017.00317.CrossRefPubMedPubMedCentral Harris EER, Small W Jr. Intraoperative radiotherapy for breast cancer. Front Oncol. 2017;7:317. https://​doi.​org/​10.​3389/​fonc.​2017.​00317.CrossRefPubMedPubMedCentral

go back to reference Morrison C, Gonzalez V, Hsu C. Intraoperative radiation therapy (IORT) as sole adjuvant RT modality for breast cancer: patterns of care in the United States and utilization after publication of guidelines and randomized trials. Int J Radiat Oncol Biol Phys. 2018;102(3):e603. https://doi.org/10.1016/j.ijrobp.2018.07.1656.CrossRef Morrison C, Gonzalez V, Hsu C. Intraoperative radiation therapy (IORT) as sole adjuvant RT modality for breast cancer: patterns of care in the United States and utilization after publication of guidelines and randomized trials. Int J Radiat Oncol Biol Phys. 2018;102(3):e603. https://​doi.​org/​10.​1016/​j.​ijrobp.​2018.​07.​1656.CrossRef

go back to reference Harness JK, Davies K, Via C, Brooks E, Zambelli-Weiner A, Shah C, Vicini F. Meta-analysis of local invasive breast cancer recurrence after electron intraoperative radiotherapy. Ann Surg Oncol. 2018;25(1):137–47. https://doi.org/10.1245/s10434-017-6130-x.CrossRefPubMed Harness JK, Davies K, Via C, Brooks E, Zambelli-Weiner A, Shah C, Vicini F. Meta-analysis of local invasive breast cancer recurrence after electron intraoperative radiotherapy. Ann Surg Oncol. 2018;25(1):137–47. https://​doi.​org/​10.​1245/​s10434-017-6130-x.CrossRefPubMed

go back to reference Chang KJ, Kuo WH, Wang MY. The epidemiology of breast cancer in Taiwan. J Chi Oncol Soc. 2008;24:85–93. Chang KJ, Kuo WH, Wang MY. The epidemiology of breast cancer in Taiwan. J Chi Oncol Soc. 2008;24:85–93.

go back to reference Lai HW, Liu LC, Ouyang F, Yao CC, Jan HC, Chang YH, Tu CW, Chen DR, Cheng TF, Tzeng YD, Hsu HM, Yeh MH, Wu YC, Yang PS, Lam HB, Hou MF, Chen FM. Multi-center study on patient selection for and the oncologic safety of intraoperative radiotherapy (IORT) with the Xoft Axxent(R) eBx(R) system for the management of early stage breast cancer in Taiwan. PLoS One. 2017;12(11):e0185876. https://doi.org/10.1371/journal.pone.0185876.CrossRefPubMedPubMedCentral Lai HW, Liu LC, Ouyang F, Yao CC, Jan HC, Chang YH, Tu CW, Chen DR, Cheng TF, Tzeng YD, Hsu HM, Yeh MH, Wu YC, Yang PS, Lam HB, Hou MF, Chen FM. Multi-center study on patient selection for and the oncologic safety of intraoperative radiotherapy (IORT) with the Xoft Axxent(R) eBx(R) system for the management of early stage breast cancer in Taiwan. PLoS One. 2017;12(11):e0185876. https://​doi.​org/​10.​1371/​journal.​pone.​0185876.CrossRefPubMedPubMedCentral

go back to reference Corica T, Joseph D, Saunders C, Bulsara M, Nowak AK. Intraoperative radiotherapy for early breast cancer: do health professionals choose convenience or risk? Radiat Oncol. 2014;9(1):33. https://doi.org/10.1186/1748-717X-9-33.CrossRefPubMedPubMedCentral Corica T, Joseph D, Saunders C, Bulsara M, Nowak AK. Intraoperative radiotherapy for early breast cancer: do health professionals choose convenience or risk? Radiat Oncol. 2014;9(1):33. https://​doi.​org/​10.​1186/​1748-717X-9-33.CrossRefPubMedPubMedCentral

go back to reference Correa C, Harris EE, Leonardi MC, Smith BD, Taghian AG, Thompson AM, White J, Harris JR. Accelerated partial breast irradiation: executive summary for the update of an ASTRO evidence-based consensus statement. Pract Radiat Oncol. 2017;7(2):73–9. https://doi.org/10.1016/j.prro.2016.09.007.CrossRefPubMed Correa C, Harris EE, Leonardi MC, Smith BD, Taghian AG, Thompson AM, White J, Harris JR. Accelerated partial breast irradiation: executive summary for the update of an ASTRO evidence-based consensus statement. Pract Radiat Oncol. 2017;7(2):73–9. https://​doi.​org/​10.​1016/​j.​prro.​2016.​09.​007.CrossRefPubMed

go back to reference Veronesi U, Orecchia R, Maisonneuve P, Viale G, Rotmensz N, Sangalli C, Luini A, Veronesi P, Galimberti V, Zurrida S, Leonardi MC, Lazzari R, Cattani F, Gentilini O, Intra M, Caldarella P, Ballardini B. Intraoperative radiotherapy versus external radiotherapy for early breast cancer (ELIOT): a randomised controlled equivalence trial. Lancet Oncol. 2013;14(13):1269–77. https://doi.org/10.1016/S1470-2045(13)70497-2.CrossRefPubMed Veronesi U, Orecchia R, Maisonneuve P, Viale G, Rotmensz N, Sangalli C, Luini A, Veronesi P, Galimberti V, Zurrida S, Leonardi MC, Lazzari R, Cattani F, Gentilini O, Intra M, Caldarella P, Ballardini B. Intraoperative radiotherapy versus external radiotherapy for early breast cancer (ELIOT): a randomised controlled equivalence trial. Lancet Oncol. 2013;14(13):1269–77. https://​doi.​org/​10.​1016/​S1470-2045(13)70497-2.CrossRefPubMed

go back to reference Vaidya JS, Wenz F, Bulsara M, Tobias JS, Joseph DJ, Keshtgar M, Flyger HL, Massarut S, Alvarado M, Saunders C, Eiermann W, Metaxas M, Sperk E, Sütterlin M, Brown D, Esserman L, Roncadin M, Thompson A, Dewar JA, Holtveg HMR, Pigorsch S, Falzon M, Harris E, Matthews A, Brew-Graves C, Potyka I, Corica T, Williams NR, Baum M. Risk-adapted targeted intraoperative radiotherapy versus whole-breast radiotherapy for breast cancer: 5-year results for local control and overall survival from the TARGIT-A randomised trial. Lancet. 2014;383(9917):603–13. https://doi.org/10.1016/S0140-6736(13)61950-9.CrossRefPubMed Vaidya JS, Wenz F, Bulsara M, Tobias JS, Joseph DJ, Keshtgar M, Flyger HL, Massarut S, Alvarado M, Saunders C, Eiermann W, Metaxas M, Sperk E, Sütterlin M, Brown D, Esserman L, Roncadin M, Thompson A, Dewar JA, Holtveg HMR, Pigorsch S, Falzon M, Harris E, Matthews A, Brew-Graves C, Potyka I, Corica T, Williams NR, Baum M. Risk-adapted targeted intraoperative radiotherapy versus whole-breast radiotherapy for breast cancer: 5-year results for local control and overall survival from the TARGIT-A randomised trial. Lancet. 2014;383(9917):603–13. https://​doi.​org/​10.​1016/​S0140-6736(13)61950-9.CrossRefPubMed

go back to reference Zhang L, Zhou Z, Mei X, Yang Z, Ma J, Chen X, Wang J, Liu G, Yu X, Guo X. Intraoperative radiotherapy versus whole-breast external beam radiotherapy in early-stage breast cancer: a systematic review and meta-analysis. Medicine. 2015;94(27):e1143. https://doi.org/10.1097/MD.0000000000001143.CrossRefPubMedPubMedCentral Zhang L, Zhou Z, Mei X, Yang Z, Ma J, Chen X, Wang J, Liu G, Yu X, Guo X. Intraoperative radiotherapy versus whole-breast external beam radiotherapy in early-stage breast cancer: a systematic review and meta-analysis. Medicine. 2015;94(27):e1143. https://​doi.​org/​10.​1097/​MD.​0000000000001143​.CrossRefPubMedPubMedCentral

go back to reference Gentilini O, Botteri E, Leonardi MC, Rotmensz N, Vila J, Peradze N, Thomazini MV, Jereczek BA, Galimberti V, Luini A, Veronesi P, Orecchia R. Ipsilateral axillary recurrence after breast conservative surgery: the protective effect of whole breast radiotherapy. Radiother Oncol. 2017;122(1):37–44. https://doi.org/10.1016/j.radonc.2016.12.021.CrossRefPubMed Gentilini O, Botteri E, Leonardi MC, Rotmensz N, Vila J, Peradze N, Thomazini MV, Jereczek BA, Galimberti V, Luini A, Veronesi P, Orecchia R. Ipsilateral axillary recurrence after breast conservative surgery: the protective effect of whole breast radiotherapy. Radiother Oncol. 2017;122(1):37–44. https://​doi.​org/​10.​1016/​j.​radonc.​2016.​12.​021.CrossRefPubMed

go back to reference Polgar C, Van Limbergen E, Potter R, Kovacs G, Polo A, Lyczek J, Hildebrandt G, Niehoff P, Guinot JL, Guedea F, et al. Patient selection for accelerated partial-breast irradiation (APBI) after breast-conserving surgery: recommendations of the Groupe Europeen de Curietherapie-European Society for Therapeutic Radiology and Oncology (GEC-ESTRO) breast cancer working group based on clinical evidence (2009). Radiother Oncol. 2010;94(3):264–73. https://doi.org/10.1016/j.radonc.2010.01.014.CrossRefPubMed Polgar C, Van Limbergen E, Potter R, Kovacs G, Polo A, Lyczek J, Hildebrandt G, Niehoff P, Guinot JL, Guedea F, et al. Patient selection for accelerated partial-breast irradiation (APBI) after breast-conserving surgery: recommendations of the Groupe Europeen de Curietherapie-European Society for Therapeutic Radiology and Oncology (GEC-ESTRO) breast cancer working group based on clinical evidence (2009). Radiother Oncol. 2010;94(3):264–73. https://​doi.​org/​10.​1016/​j.​radonc.​2010.​01.​014.CrossRefPubMed

go back to reference Leonardi MC, Maisonneuve P, Mastropasqua MG, Morra A, Lazzari R, Rotmensz N, Sangalli C, Luini A, Veronesi U, Orecchia R. How do the ASTRO consensus statement guidelines for the application of accelerated partial breast irradiation fit intraoperative radiotherapy? A retrospective analysis of patients treated at the European Institute of Oncology. Int J Radiat Oncol Biol Phys. 2012;83(3):806–13. https://doi.org/10.1016/j.ijrobp.2011.08.014.CrossRefPubMed Leonardi MC, Maisonneuve P, Mastropasqua MG, Morra A, Lazzari R, Rotmensz N, Sangalli C, Luini A, Veronesi U, Orecchia R. How do the ASTRO consensus statement guidelines for the application of accelerated partial breast irradiation fit intraoperative radiotherapy? A retrospective analysis of patients treated at the European Institute of Oncology. Int J Radiat Oncol Biol Phys. 2012;83(3):806–13. https://​doi.​org/​10.​1016/​j.​ijrobp.​2011.​08.​014.CrossRefPubMed

go back to reference Strnad V, Ott OJ, Hildebrandt G, Kauer-Dorner D, Knauerhase H, Major T, Lyczek J, Guinot JL, Dunst J, Gutierrez Miguelez C, Slampa P, Allgäuer M, Lössl K, Polat B, Kovács G, Fischedick AR, Wendt TG, Fietkau R, Hindemith M, Resch A, Kulik A, Arribas L, Niehoff P, Guedea F, Schlamann A, Pötter R, Gall C, Malzer M, Uter W, Polgár C, Groupe Européen de Curiethérapie of European Society for Radiotherapy and Oncology (GEC-ESTRO). 5-year results of accelerated partial breast irradiation using sole interstitial multicatheter brachytherapy versus whole-breast irradiation with boost after breast-conserving surgery for low-risk invasive and in-situ carcinoma of the female breast: a randomised, phase 3, non-inferiority trial. Lancet. 2016;387(10015):229–38. https://doi.org/10.1016/S0140-6736(15)00471-7.CrossRefPubMed Strnad V, Ott OJ, Hildebrandt G, Kauer-Dorner D, Knauerhase H, Major T, Lyczek J, Guinot JL, Dunst J, Gutierrez Miguelez C, Slampa P, Allgäuer M, Lössl K, Polat B, Kovács G, Fischedick AR, Wendt TG, Fietkau R, Hindemith M, Resch A, Kulik A, Arribas L, Niehoff P, Guedea F, Schlamann A, Pötter R, Gall C, Malzer M, Uter W, Polgár C, Groupe Européen de Curiethérapie of European Society for Radiotherapy and Oncology (GEC-ESTRO). 5-year results of accelerated partial breast irradiation using sole interstitial multicatheter brachytherapy versus whole-breast irradiation with boost after breast-conserving surgery for low-risk invasive and in-situ carcinoma of the female breast: a randomised, phase 3, non-inferiority trial. Lancet. 2016;387(10015):229–38. https://​doi.​org/​10.​1016/​S0140-6736(15)00471-7.CrossRefPubMed

go back to reference Polgar C, Fodor J, Major T, Sulyok Z, Kasler M. Breast-conserving therapy with partial or whole breast irradiation: ten-year results of the Budapest randomized trial. Radiother Oncol. 2013;108(2):197–202. https://doi.org/10.1016/j.radonc.2013.05.008.CrossRefPubMed Polgar C, Fodor J, Major T, Sulyok Z, Kasler M. Breast-conserving therapy with partial or whole breast irradiation: ten-year results of the Budapest randomized trial. Radiother Oncol. 2013;108(2):197–202. https://​doi.​org/​10.​1016/​j.​radonc.​2013.​05.​008.CrossRefPubMed

go back to reference Livi L, Meattini I, Marrazzo L, Simontacchi G, Pallotta S, Saieva C, Paiar F, Scotti V, De Luca CC, Bastiani P, et al. Accelerated partial breast irradiation using intensity-modulated radiotherapy versus whole breast irradiation: 5-year survival analysis of a phase 3 randomised controlled trial. Eur J Cancer. 2015;51(4):451–63. https://doi.org/10.1016/j.ejca.2014.12.013.CrossRefPubMed Livi L, Meattini I, Marrazzo L, Simontacchi G, Pallotta S, Saieva C, Paiar F, Scotti V, De Luca CC, Bastiani P, et al. Accelerated partial breast irradiation using intensity-modulated radiotherapy versus whole breast irradiation: 5-year survival analysis of a phase 3 randomised controlled trial. Eur J Cancer. 2015;51(4):451–63. https://​doi.​org/​10.​1016/​j.​ejca.​2014.​12.​013.CrossRefPubMed

go back to reference El Saghir NS, Seoud M, Khalil MK, Charafeddine M, Salem ZK, Geara FB, Shamseddine AI. Effects of young age at presentation on survival in breast cancer. BMC Cancer. 2006;6(1):194. https://doi.org/10.1186/1471-2407-6-194.CrossRefPubMedPubMedCentral El Saghir NS, Seoud M, Khalil MK, Charafeddine M, Salem ZK, Geara FB, Shamseddine AI. Effects of young age at presentation on survival in breast cancer. BMC Cancer. 2006;6(1):194. https://​doi.​org/​10.​1186/​1471-2407-6-194.CrossRefPubMedPubMedCentral

go back to reference Kirby AM. Updated ASTRO guidelines on accelerated partial breast irradiation (APBI): to whom can we offer APBI outside a clinical trial? Br J Radiol. 2018;91(1085):20170565. https://doi.org/10.1259/bjr.20170565.CrossRefPubMedPubMedCentral Kirby AM. Updated ASTRO guidelines on accelerated partial breast irradiation (APBI): to whom can we offer APBI outside a clinical trial? Br J Radiol. 2018;91(1085):20170565. https://​doi.​org/​10.​1259/​bjr.​20170565.CrossRefPubMedPubMedCentral

go back to reference Cedolini C, Bertozzi S, Seriau L, Londero AP, Concina S, Moretti E, Padovani R, Pasqualucci A, Ceschia T, Risaliti A. Feasibility of concervative breast surgery and intraoperative radiation therapy for early breast cancer: a single-center, open, non-randomized, prospective pilot study. Oncol Rep. 2014;31(4):1539–46. https://doi.org/10.3892/or.2014.3018.CrossRefPubMedPubMedCentral Cedolini C, Bertozzi S, Seriau L, Londero AP, Concina S, Moretti E, Padovani R, Pasqualucci A, Ceschia T, Risaliti A. Feasibility of concervative breast surgery and intraoperative radiation therapy for early breast cancer: a single-center, open, non-randomized, prospective pilot study. Oncol Rep. 2014;31(4):1539–46. https://​doi.​org/​10.​3892/​or.​2014.​3018.CrossRefPubMedPubMedCentral

go back to reference Hanna SA, de Barros ACSD, de Andrade FEM, Bevilacqua JLB, Piato JRM, Pelosi EL, Martella E, da Silva JLF, de Andrade Carvalho H. Intraoperative radiation therapy in early breast cancer using a linear accelerator outside of the operative suite: an “image-guided” approach. Int J Radiat Oncol Biol Phys. 2014;89(5):1015–23. https://doi.org/10.1016/j.ijrobp.2014.04.038.CrossRefPubMed Hanna SA, de Barros ACSD, de Andrade FEM, Bevilacqua JLB, Piato JRM, Pelosi EL, Martella E, da Silva JLF, de Andrade Carvalho H. Intraoperative radiation therapy in early breast cancer using a linear accelerator outside of the operative suite: an “image-guided” approach. Int J Radiat Oncol Biol Phys. 2014;89(5):1015–23. https://​doi.​org/​10.​1016/​j.​ijrobp.​2014.​04.​038.CrossRefPubMed

go back to reference Kawamura M, Itoh Y, Sawaki M, Kikumori T, Tsunoda N, Kamomae T, Kubota S, Okada T, Nakahara R, Ito J. A phase I/II trial of intraoperative breast radiotherapy in an Asian population: 5-year results of local control and cosmetic outcome. Radiat Oncol. 2015;10(1):1–6.CrossRef Kawamura M, Itoh Y, Sawaki M, Kikumori T, Tsunoda N, Kamomae T, Kubota S, Okada T, Nakahara R, Ito J. A phase I/II trial of intraoperative breast radiotherapy in an Asian population: 5-year results of local control and cosmetic outcome. Radiat Oncol. 2015;10(1):1–6.CrossRef

go back to reference Philippson C, Simon S, Vandekerkhove C, Hertens D, Veys I, Noterman D, De Neubourg F, Larsimont D, Bourgeois P, Van Houtte P. Early invasive cancer and partial intraoperative electron radiation therapy of the breast: experience of the Jules Bordet Institute. Int J Breast Cancer. 2014;2014:1–6. https://doi.org/10.1155/2014/627352.CrossRef Philippson C, Simon S, Vandekerkhove C, Hertens D, Veys I, Noterman D, De Neubourg F, Larsimont D, Bourgeois P, Van Houtte P. Early invasive cancer and partial intraoperative electron radiation therapy of the breast: experience of the Jules Bordet Institute. Int J Breast Cancer. 2014;2014:1–6. https://​doi.​org/​10.​1155/​2014/​627352.CrossRef

go back to reference Wang X, Liu J, Wang W, Feng Q, Wang X. Clinical analysis of intraoperative radiotherapy during breast-conserving surgery of early breast cancer in the Chinese Han population. Oncotarget. 2015;6(40):43120–6. https://doi.org/10.18632/oncotarget.5716.CrossRefPubMedPubMedCentral Wang X, Liu J, Wang W, Feng Q, Wang X. Clinical analysis of intraoperative radiotherapy during breast-conserving surgery of early breast cancer in the Chinese Han population. Oncotarget. 2015;6(40):43120–6. https://​doi.​org/​10.​18632/​oncotarget.​5716.CrossRefPubMedPubMedCentral

go back to reference Victoor A, Noordman J, Potappel A, Meijers M, Kloek CJJ, de Jong JD. Discussing patients’ insurance and out-of-pocket expenses during GPs' consultations. BMC Health Serv Res. 2019;19(1):141. https://doi.org/10.1186/s12913-019-3966-8.CrossRefPubMedPubMedCentral Victoor A, Noordman J, Potappel A, Meijers M, Kloek CJJ, de Jong JD. Discussing patients’ insurance and out-of-pocket expenses during GPs' consultations. BMC Health Serv Res. 2019;19(1):141. https://​doi.​org/​10.​1186/​s12913-019-3966-8.CrossRefPubMedPubMedCentral

go back to reference Dunn J, Steginga SK. Young women’s experience of breast cancer: defining young and identifying concerns. Psychooncology. 2000;9(2):137–46. https://doi.org/10.1002/(SICI)1099-1611(200003/04)9:2<137::AID-PON442>3.0.CO;2-0.CrossRefPubMed Dunn J, Steginga SK. Young women’s experience of breast cancer: defining young and identifying concerns. Psychooncology. 2000;9(2):137–46. https://​doi.​org/​10.​1002/​(SICI)1099-1611(200003/​04)9:​2<137:​:​AID-PON442>3.​0.​CO;2-0.CrossRefPubMed

go back to reference Broman K, Sun W, Zhou JM, Fridley B, Diaz R, Laronga C. Outcomes of selective whole breast irradiation following lumpectomy with intraoperative radiation therapy for hormone receptor positive breast cancer. Am J Sur. 2019;218(4):749–54. https://doi.org/10.1016/j.amjsurg.2019.07.011.CrossRef Broman K, Sun W, Zhou JM, Fridley B, Diaz R, Laronga C. Outcomes of selective whole breast irradiation following lumpectomy with intraoperative radiation therapy for hormone receptor positive breast cancer. Am J Sur. 2019;218(4):749–54. https://​doi.​org/​10.​1016/​j.​amjsurg.​2019.​07.​011.CrossRef

go back to reference Lei J, Wang Y, Bi Z, Xue S, Ou B, Liu K. Intraoperative radiotherapy (IORT) versus whole-breast external beam radiotherapy (EBRT) in early stage breast cancer: results from SEER database. Jpn J Radiol. 2020;38(1):85–92. https://doi.org/10.1007/s11604-019-00891-7.CrossRefPubMed Lei J, Wang Y, Bi Z, Xue S, Ou B, Liu K. Intraoperative radiotherapy (IORT) versus whole-breast external beam radiotherapy (EBRT) in early stage breast cancer: results from SEER database. Jpn J Radiol. 2020;38(1):85–92. https://​doi.​org/​10.​1007/​s11604-019-00891-7.CrossRefPubMed

go back to reference Komoike Y, Akiyama F, Iino Y, Ikeda T, Akashi-Tanaka S, Ohsumi S, Kusama M, Sano M, Shin E, Suemasu K, Sonoo H, Taguchi T, Nishi T, Nishimura R, Haga S, Mise K, Kinoshita T, Murakami S, Yoshimoto M, Tsukuma H, Inaji H. Ipsilateral breast tumor recurrence (IBTR) after breast-conserving treatment for early breast cancer: risk factors and impact on distant metastases. Cancer. 2006;106(1):35–41. https://doi.org/10.1002/cncr.21551.CrossRefPubMed Komoike Y, Akiyama F, Iino Y, Ikeda T, Akashi-Tanaka S, Ohsumi S, Kusama M, Sano M, Shin E, Suemasu K, Sonoo H, Taguchi T, Nishi T, Nishimura R, Haga S, Mise K, Kinoshita T, Murakami S, Yoshimoto M, Tsukuma H, Inaji H. Ipsilateral breast tumor recurrence (IBTR) after breast-conserving treatment for early breast cancer: risk factors and impact on distant metastases. Cancer. 2006;106(1):35–41. https://​doi.​org/​10.​1002/​cncr.​21551.CrossRefPubMed

go back to reference Houssami N, Macaskill P, Marinovich ML, Dixon JM, Irwig L, Brennan ME, Solin LJ. Meta-analysis of the impact of surgical margins on local recurrence in women with early-stage invasive breast cancer treated with breast-conserving therapy. Eur J Cancer. 2010;46(18):3219–32. https://doi.org/10.1016/j.ejca.2010.07.043.CrossRefPubMed Houssami N, Macaskill P, Marinovich ML, Dixon JM, Irwig L, Brennan ME, Solin LJ. Meta-analysis of the impact of surgical margins on local recurrence in women with early-stage invasive breast cancer treated with breast-conserving therapy. Eur J Cancer. 2010;46(18):3219–32. https://​doi.​org/​10.​1016/​j.​ejca.​2010.​07.​043.CrossRefPubMed

go back to reference Sopik V, Nofech-Mozes S, Sun P, Narod SA. The relationship between local recurrence and death in early-stage breast cancer. Breast Cancer Res Treat. 2016;155(1):175–85. https://doi.org/10.1007/s10549-015-3666-y.CrossRefPubMed Sopik V, Nofech-Mozes S, Sun P, Narod SA. The relationship between local recurrence and death in early-stage breast cancer. Breast Cancer Res Treat. 2016;155(1):175–85. https://​doi.​org/​10.​1007/​s10549-015-3666-y.CrossRefPubMed

go back to reference Vickberg S. Fears about breast cancer recurrence: interviews with a diverse sample. Cancer Pract. 2001;9(5):237–43. https://doi.org/10.1046/j.1523-5394.2001.009005237.x.CrossRef Vickberg S. Fears about breast cancer recurrence: interviews with a diverse sample. Cancer Pract. 2001;9(5):237–43. https://​doi.​org/​10.​1046/​j.​1523-5394.​2001.​009005237.​x.CrossRef

go back to reference Northouse LL, Mood D, Kershaw T, Schafenacker A, Mellon S, Walker J, Galvin E, Decker V. Quality of life of women with recurrent breast cancer and their family members. J Clin Oncol. 2002;20(19):4050–64. https://doi.org/10.1200/JCO.2002.02.054.CrossRefPubMed Northouse LL, Mood D, Kershaw T, Schafenacker A, Mellon S, Walker J, Galvin E, Decker V. Quality of life of women with recurrent breast cancer and their family members. J Clin Oncol. 2002;20(19):4050–64. https://​doi.​org/​10.​1200/​JCO.​2002.​02.​054.CrossRefPubMed