Published in:
01-11-2021 | Breast Cancer | ASO Author Reflections
ASO Author Reflections: High BRCA2 Gene Expression is Associated with Aggressive and Highly Proliferative Breast Cancer
Authors:
Vikas Satyananda, MD, Masanori Oshi, MD, PhD, Itaru Endo, MD, PhD, Kazuaki Takabe, MD, PhD, FACS
Published in:
Annals of Surgical Oncology
|
Issue 12/2021
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Excerpt
BRCA2 is one of the most studied genetic mutations associated with hereditary forms of breast cancer.
BRCA2 mediates double-stranded DNA repair and stabilizes chromosomes. Unlike
BRCA2 mutation, the clinical relevance of
BRCA2 gene expression is less well studied. The availability of economically viable technology has led to generation and accumulation of vast data on gene expression of tumors in large cohorts of patients. Recent advances in computational biology allow us to conduct research that assesses the real-world relevance of the expression of genes of interest, such as glucocorticoid receptor
1, nuclear factor erythroid 2-related factor 2 (NRF2)
2, inositol 1,4,5-trisphosphate 3-kinase C (ITPKC)
3, and annexin A1
4 in breast cancer to name just a few. …
