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Cancer Causes & Control
Published in: Cancer Causes & Control 2/2020

01-02-2020 | Breast Cancer | Original Paper

Alcohol consumption and serum metabolite concentrations in young women

Authors: Joanne F. Dorgan, Seungyoun Jung, Cher M. Dallal, Min Zhan, Christina A. Stennett, Yuji Zhang, Richard L. Eckert, Linda G. Snetselaar, Linda Van Horn

Published in: Cancer Causes & Control | Issue 2/2020

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Abstract

Purpose

Alcohol consumption is an established breast cancer risk factor, though further research is needed to advance our understanding of the mechanism underlying the association. We used global metabolomics profiling to identify serum metabolites and metabolic pathways that could potentially mediate the alcohol–breast cancer association.

Methods

A cross-sectional analysis of reported alcohol consumption and serum metabolite concentrations was conducted among 211 healthy women 25–29 years old who participated in the Dietary Intervention Study in Children 2006 Follow-Up Study (DISC06). Alcohol–metabolite associations were evaluated using multivariable linear mixed-effects regression.

Results

Alcohol was significantly (FDR p < 0.05) associated with several serum metabolites after adjustment for diet composition and other potential confounders. The amino acid sarcosine, the omega-3 fatty acid eicosapentaenoate, and the steroid 4-androsten-3beta,17beta-diol monosulfate were positively associated with alcohol intake, while the gamma-tocopherol metabolite gamma-carboxyethyl hydroxychroman (CEHC) was inversely associated. Positive associations of alcohol with 2-methylcitrate and 4-androsten-3beta,17beta-diol disulfate were borderline significant (FDR p < 0.10). Metabolite set enrichment analysis identified steroids and the glycine pathway as having more members associated with alcohol consumption than expected by chance.

Conclusions

Most of the metabolites associated with alcohol in the current analysis participate in pathways hypothesized to mediate the alcohol–breast cancer association including hormonal, one-carbon metabolism, and oxidative stress pathways, but they could also affect risk via alternative pathways. Independent replication of alcohol–metabolite associations and prospective evaluation of confirmed associations with breast cancer risk are needed.
Appendix
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Footnotes
1
Children’s Hospital, New Orleans, LA; Johns Hopkins Hospital, Baltimore, MD, Kaiser Permanente Center for Health Research, Portland, OR; University of Medicine and Dentistry of New Jersey, Newark, NJ; Northwestern University Medical School, Chicago, IL; University of Iowa Hospital and Clinics, Iowa City, IA.
 
2
Maryland Medical Research Institute, Baltimore, MD.
 
Literature
1.
American Cancer Society (2017) Cancer facts & figures 2017
2.
Allen N, Beral V, Casabonne D, Kan S, Reeves G, Brown A, Green J, Collaborators oboMWS (2009) Moderate alcohol intake and cancer incidence in women. J Natl Cancer Inst 101:296–305CrossRefPubMed
3.
Chen W, Rosner B, Hankinson S, Colditz G, Willett W (2011) Moderate alcohol consumption during adult life, drinking patterns, and breast cancer risk. JAMA 306:1884–1890CrossRefPubMedPubMedCentral
4.
Collaborative Group on Hormonal Factors in Breast Cancer (2002) Alcohol, tobacco and breast cancer - collaborative reanalysis of individual data from 53 epidemiologic studies, including 58515 women with breast cancer and 95067 women without the disease. Br J Cancer 87:1234–1245CrossRefPubMedCentral
5.
Smith-Warner SA, Spiegelman D, Yaun SS, van den Brandt PA, Folsom AR, Goldbohm RA, Graham S, Holmberg L, Howe GR, Marshall JR, Miller AB, Potter JD, Speizer FE, Willett WC, Wolk A, Hunter DJ (1998) Alcohol and breast cancer in women: a pooled analysis of cohort studies. JAMA 279:535–540CrossRefPubMed
6.
Jung S, Wang M, Anderson K, Baglietto L, Bergkvist L, Bernstein L, van den Brandt PA, Brinton L, Buring JE, Eliassen AH, Falk R, Gapstur SM, Giles GG, Goodman G, Hoffman-Bolton J, Horn-Ross PL, Inoue M, Kolonel LN, Krogh V, Lof M, Maas P, Miller AB, Neuhouser ML, Park Y, Robien K, Rohan TE, Scarmo S, Schouten LJ, Sieri S, Stevens VL, Tsugane S, Visvanathan K, Wilkens LR, Wolk A, Weiderpass E, Willett WC, Zeleniuch-Jacquotte A, Zhang SM, Zhang X, Ziegler RG, Smith-Warner SA (2016) Alcohol consumption and breast cancer risk by estrogen receptor status: in a pooled analysis of 20 studies. Int J Epidemiol 45:916–928CrossRefPubMed
7.
8.
Endogenous Hormones and Breast Cancer Collaborative Group, Key T, Appleby P, Reeves G, Travis R, Alberg A, Barricarte A, Berrino F, Krogh V, Sieri S, Brinton L, Dorgan J, Dossus L, Dowsett M, Eliassen A, Fortner R, Hankinson S, Helzlsouer K, Hoff man-Bolton J, Comstock G, Kaaks R, Kahle L, Muti P, Overvad K, Peeters P, Riboli E, Rinaldi S, Rollison D, Stanczyk F, Trichopoulos D, Tworoger S, Vineis P, (2013) Sex hormones and risk of breast cancer in premenopausal women: a collaborative reanalysis of individual participant data from seven prospective studies. Lancet Oncol 14:1009–1019CrossRefPubMedCentral
9.
The Endogenous Hormones and Breast Collaborative Group (2002) Endogenous sex hormones and breast cancer in postmenopausal women: reanalysis of nine prospective studies. J Natl Cancer Inst 94:606–616CrossRef
10.
Hamid A, Wani N, Kaur J (2009) New perspectives on folate transport in relation to alcoholism-induced folate malabsorption-association with epigenome stability and cancer development. FEBS J 276:2175–2191CrossRefPubMed
11.
Kruman I, Fowler A (2014) Impaired one carbon metabolism and DNA methylation in alcohol toxicity. J Neurochem 129:770–780CrossRefPubMed
12.
Varela-Rey M, Woodhoo A, Martinez-Chantar M, Mato J, Lu S (2013) Alcohol, DNA methylation, and cancer. Alcohol Res 35:25–35PubMedPubMedCentral
13.
Anderson O, Sant K, Dolinoy D (2012) Nutrition and epigenetics: an interplay of dietary methyl donors, one-carbon metabolism and DNA methylation. J Nutr Biochem 23:853–859CrossRefPubMedPubMedCentral
14.
15.
Triano E, Slusher L, Atkins T, Beneski J, Gestl S, Zolfaghari R, Polavarapu R, Frauenhoffer E, Weisz J (2003) Class I alcohol dehydrogenase is highly expressed in normal human mammary epithelium but not in invasive breast cancer: implications for breast carcinogenesis. Cancer Res 63:3092–3100PubMed
16.
Seitz H, Stickel F (2007) Molecular mechanisms of alcohol-mediated carcinogenesis. Nat Rev Cancer 7:599–612CrossRefPubMed
17.
Guertin K, Moore S, Sampson J, Huang W, Xiao Q, Stolzenberg-Solomon R, Sinha R, Cross A (2014) Metabolomics in nutritional epidemiology: identifying metabolites associated with diet and quantifying their potential to uncover diet-disease relations in populations. Am J Clin Nutr 100:208–217CrossRefPubMedPubMedCentral
18.
Harada S, Takebayashi T, Kurihara A, Akiyama M, Suzuki A, Hatakeyama Y, Sugiyama D, Kuwabara K, Takeuchi A, Okamura T, Nishiwaki Y, Tanaka T, Hirayama A, Sugimoto M, Soga T, Tomita M (2016) Metabolomic profiling reveals novel biomarkers of alcohol intake and alcohol-induced liver injury in community-dwelling men. Environ Health Prev Med 21:18–26CrossRefPubMed
19.
Jaremek M, Yu Z, Mangino M, Mittelstrass K, Prehn C, Singmann P, Xu T, Dahmen N, Weinberger K, Suhre K, Peters A, Döring A, Hauner H, Adamski J, Illig T, Spector T, Wang-Sattler R (2013) Alcohol-induced metabolomic differences in humans. Transl Psychiatry 3:e276CrossRefPubMedPubMedCentral
20.
Würtz P, Cook S, Wang Q, Tiainen M, Tynkkynen T, Kangas A, Soininen P, Laitinen J, Viikari J, Kähönen M, Lehtimäki T, Perola M, Blankenberg S, Zeller T, Männistö S, Salomaa V, Järvelin M, Raitakari O, Ala-Korpela M, Leon D (2016) Metabolic profiling of alcohol consumption in 9778 young adults. Int J Epidemiol 45:1493–1506CrossRefPubMedPubMedCentral
21.
Zheng Y, Yu B, Alexander D, Steffen L, Nettleton J, Boerwinkle E (2014) Metabolomic patterns and alcohol consumption in African Americans in the Atherosclerosis Risk in Communities Study. Am J Clin Nutr 99:1470–1478CrossRefPubMedPubMedCentral
22.
Colditz G, Giovannucci E, Rimm E, Stampfer M, Rosner B, Speizer F, Gordis E, Willett W (1991) Alcohol intake in relation to diet and obesity in women and men. Am J Clin Nutr 54:49–55CrossRefPubMed
23.
24.
Ruidavets J, Bataille V, Dallongeville J, Simon C, Bingham A, Amouyel P, Arveiler D, Ducimetière P, Ferrières J (2004) Alcohol intake and diet in France, the prominent role of lifestyle. Eur Heart J 25:1153–1162CrossRefPubMed
25.
Sieri S, Krogh V, Saieva C, Grobbee D, Bergmann M, Rohrmann S, Tjønneland A, Ferrari P, Chloptsios Y, Dilis V, Jenab M, Linseisen J, Wallström P, Johansson I, Chirlaque M, Sanchez M, Niravong M, Clavel-Chapelon F, Welch A, Allen N, Bueno-de-Mesquita H, van der Schouw Y, Sacerdote C, Panico S, Parr C, Braaten T, Olsen A, Jensen M, Bingham S, Riboli E, Slimani N (2009) Alcohol consumption patterns, diet and body weight in 10 European countries. Eur J Clin Nutr 63:S81–100CrossRefPubMed
26.
DISC Collaborative Research Group (1993) Dietary intervention study in children (DISC) with elevated low-density- lipoprotein cholesterol. Design and baseline characteristics. Ann Epidemiol 3:393–402
27.
Dorgan J, Liu L, Barton B, Deshmukh S, Snetselaar L, Van Horn L, Stevens V, Robson A, Lasser N, Himes J, Shepherd J, Pourfarzib R, Pettee Gabriel K, Kriska A, Kwiterovich P (2011) Adolescent diet and metabolic syndrome in young women: results of the Dietary Intervention Study in Children (DISC) Follow-Up Study. J Clin Endocrinol Metab 96:E1999–2008CrossRefPubMedPubMedCentral
28.
Dorgan JF, Hunsberger SA, McMahon RP, Kwiterovich PO Jr, Lauer RM, Van Horn L, Lasser NL, Stevens VJ, Friedman LA, Yanovski JA, Greenhut SF, Chandler DW, Franklin FA, Barton BA, Buckman DW, Snetselaar LG, Patterson BH, Schatzkin A, Taylor PR (2003) Diet and sex hormones in girls: findings from a randomized controlled clinical trial. J Natl Cancer Inst 95:132–141CrossRefPubMed
29.
Dorgan JF, McMahon RP, Friedman LA, Van Horn L, Snetselaar LG, Kwiterovich PO Jr, Lauer RM, Lasser NL, Stevens VJ, Robson A, Cooper SF, Chandler DW, Franklin FA, Barton BA, Patterson BH, Taylor PR, Schatzkin A (2006) Diet and sex hormones in boys: findings from the dietary intervention study in children. J Clin Endocrinol Metab 91:3992–3996CrossRefPubMed
30.
Dorgan JF, Liu L, Klifa C, Hylton N, Shepherd JA, Stanczyk FZ, Snetselaar LG, Van Horn L, Stevens VJ, Robson A, Kwiterovich PO Jr, Lasser NLH, J.H., Pettee Gabriel K, Kriska A, Ruder EH, Fang CY, Barton BA, (2010) Adolescent diet and subsequent serum hormones, breast density, and bone mineral density in young women: results of the Dietary Intervention Study in Children. Cancer Epidemiol Biomarkers Prev 19:1545–1556CrossRefPubMedPubMedCentral
31.
Obarzanek E, Hunsberger S, Van Horn L, Hartmuller V, Barton B, Stevens V, Kwiterovich PJ, Franklin F, Kimm S, Lasser N, Simons-Morton D, Lauer R (1997) Safety of a fat-reduced diet: the Dietary Intervention Study in Children (DISC). Pediatrics 100:51–59CrossRefPubMed
32.
Obarzanek E, Kimm S, Barton B, Van Horn L, Kwiterovich PJ, Simons-Morton D, Hunsberger S, Lasser N, Robson A, Franklin FJ, Lauer R, Stevens V, Friedman L, Dorgan J, Greenlick M (2001) Long-term safety and efficacy of a cholesterol-lowering diet in children with elevated low-density lipoprotein cholesterol: seven-year results of the Dietary Intervention Study in Children (DISC). Pediatrics 107:256–264CrossRefPubMed
33.
The Writing Group for the DISC Collaborative Research Group (1995) Efficacy and safety of lowering dietary intake of fat and cholesterol in children with elevated low-density lipoprotein cholesterol The Dietary Intervention Study in Children (DISC). JAMA 273:1429–1435CrossRef
34.
U.S. Public Health Service (1980) Lipid research clinics population studies data book, I: the prevalence study. Department of Health and Human Services, Public Health Service, Bethesda (MD), U.S
35.
Weber L (1987) Bogalusa Heart Study height and weight percentiles.
36.
Tanner JM (1962) Growth at adolescence, 2nd edn. Blackwell Scientific, Oxford
37.
Achenbach TM, Edelbrook C (1983) Manual for the child behavior checklist. University of Vermont, Burlington
38.
Kriska AM (1997) Historical leisure activity questionnaire. Med Sci Sport Exerc 29:S43–S45
39.
Leys C, Ley C, Klein O, Bernard P, Licata L (2013) Detecting outliers: do not use standard deviation around the mean, use absolute deviation around the median. JESP 49:764–766
40.
Benjamini Y, Hochberg Y (1995) Controlling the false discovery rate: a practical and powerful approach to multiple testing. J R Stat Soc Ser B 1:289–300
41.
Tingley D, Yamamoto T, Hirose K, Keele L, Imai K (2014) Mediation: R package for causal mediation analysis. J Stat Softw 59:1–38CrossRef
42.
43.
44.
Imai K, Keele L, Yamamoto T (2010) Identification, inference and sensitivity analysis for causal mediation effects. Stat Sci 25:51–71CrossRef
45.
Playdon M, Ziegler R, Sampson J, Stolzenberg-Solomon R, Thompson H, Irwin M, Mayne S, Hoover R, Moore S (2017) Nutritional metabolomics and breast cancer risk in a prospective study. Am J Clin Nutr 106:637–649CrossRefPubMedPubMedCentral
46.
Rajdl D, Racek J, Trefil L, Stehlik P, Dobra J, Babuska V (2016) Effect of folic acid, betaine, vitamin B6, and vitamin B12 on homocysteine and dimethylglycine levels in middle-aged men drinking white wine. Nutrients 8:E34CrossRefPubMed
47.
48.
Pellanda H (2013) Betaine homocysteine methyltransferase (BHMT)-dependent remethylation pathway in human healthy and tumoral liver. Clin Chem Lab Med 51:617–621CrossRefPubMed
49.
Cha Y, Jung W, Cho N, Koo J (2015) Expression of sarcosine metabolism-related proteins in invasive lobular carcinoma: comparison to invasive ductal carcinoma. Yonsei Med J 56:598–607CrossRefPubMedPubMedCentral
50.
Kim M, Jung W, Koo J (2015) Expression of sarcosine metabolism-related proteins in estrogen receptor negative breast cancer according to the androgen receptor and HER-2 status. Int J Clin Exp Pathol 8:7967–7977PubMedPubMedCentral
51.
Yoon J, Kim D, Koo J (2014) Implications of differences in expression of sarcosine metabolism-related proteins according to the molecular subtype of breast cancer. J Transl Med 12:149CrossRefPubMedPubMedCentral
52.
Al Dhahouri N, Langhans C, Al Hammadi Z (2018) Quantification of methylcitrate in dried urine spots by liquid chromatography tandem mass spectrometry for the diagnosis of propionic and methylmalonic acidemias. Clin Chim Acta 487:41–45CrossRefPubMed
53.
Dolan S, Wijaya A, Geddis S, Spring D, Silva-Rocha R, Welch M (2018) Loving the poison: methylcitrate and bacterial pathogenesis. Microbiology 164:251–259CrossRefPubMed
54.
Laufer EM, Hartman TJ, Baer DJ, Gunter EW, Dorgan JF, Campbell WS, Clevidence BA, Brown ED, Albanes D, Judd JT, Taylor PR (2004) Effects of moderate alcohol consumption on folate and vitamin B(12) status in postmenopausal women. Eur J Clin Nutr 58:1518–1524CrossRefPubMed
55.
Henning B, Tepel M, Riezler R, Naurath H (2001) Long-term effects of vitamin B(12), folate, and vitamin B(6) supplements in elderly people with normal serum vitamin B(12) concentrations. Gerontology 47:30–35CrossRefPubMed
56.
Johnson M, Hausman D, Davey A, Poon L, Allen R, Stabler S, Georgia Centarian Study (2010) Vitamin B12 deficiency in African American and White octogenarians and centenarians in Georgia. J Nutr Health Aging 14:339–345CrossRef
57.
58.
Ju J, Picinich S, Yang Z, Zhao Y, Suh N, Kong A, Yang C (2010) Cancer-preventive activities of tocopherols and tocotrienols. Carcinogenesis 31:533–542CrossRefPubMed
59.
Wagner K, Kamal-Eldin A, Elmadfa I (2004) Gamma-tocopherol: an underestimated vitamin. Ann Nutr Metab 48:169–188CrossRefPubMed
60.
Hensley K, Benaksas E, Bolli R, Comp P, Grammas P, Hamdheydari L, Mou S, Pye Q, Stoddard M, Wallis G, Williamson K, West M, Wechter W, Floyd R (2004) New perspectives on vitamin E: gamm-tocopherol and carboxyethylhydroxychroman metabolites in biology and medicine. Free Radic Biol Med 36:1–15CrossRefPubMed
61.
Jiang Q, Christian S, Shigenaga M, Ames B (2001) gamma-Tocopherol, the major form of vitamin E in the US diet, deserves more attention. Am J Clin Nutr 74:714–722CrossRefPubMed
62.
Faure H, Preziosi P, Roussel A, Bertrais S, Galan P, Hercberg S, Favier A (2006) Factors influencing blood concentration of retinol, alpha-tocopherol, vitamin C, and beta-carotene in the French participants of the SUVIMAX trial. Eur J Clin Nutr 60:706–717CrossRefPubMed
63.
Galan P, Viteri F, Bertrais S, Czernichow S, Faure H, Arnaud J, Ruffieux D, Chenal S, Arnault N, Favier A, Roussel A, Hercberg S (2005) Serum concentrations of beta-carotene, vitamins C and E, zinc and selenium are influenced by sex, age, diet, smoking status, alcohol consumption and corpulence in a general French adult population. Eur J Clin Nutr 59:1181–1190CrossRefPubMed
64.
Woodside J, Young I, Gilchrist S, Vioque J, Chakravarthy U, de Jong P, Rahu M, Seland J, Soubrane G, Tomazzoli L, Topouzis F, Vingerling J, Fletcher A (2013) Factors associated with serum/plasma concentrations of vitamins A, C, E and carotenoids in older people throughout Europe: the EUREYE study. Eur J Nutr 52:1493–1501CrossRefPubMed
65.
Zou Y, Wang D, Sakano N, Sato Y, Iwanaga S, Taketa K, Kubo M, Takemoto K, Masatomi C, Inoue K, Ogino K (2014) Associations of serum retinol, α-tocopherol, and γ-tocopherol with biomarkers among healthy Japanese men. Int J Environ Res Public Health 11:1647–1660CrossRefPubMedPubMedCentral
66.
Hartman TJ, Baer DJ, Graham LB, Stone WL, Gunter EW, Parker CE, Albert PS, Dorgan JF, Clevidence BA, Campbell WS, Tomer KB, Judd JT, Taylor PR (2005) Moderate alcohol consumption and levels of antioxidant vitamins and isoprostanes in postmenopausal women. Eur J Clin Nutr 59:161–168CrossRefPubMed
67.
Smolarek A, So J, Burgess B, Kong A, Reuhl K, Lin Y (2012) Dietary administration of delta- and gamma-tocopherol inhibits tumorigenesis in the animal model of estrogen receptor-positive, but not HER-2 breast cancer. Cancer Prev Res 5:1310–1320CrossRef
68.
Bakker M, Peeters P, Klaasen V, Bueno-de-Mesquita H, Jansen E, Ros M, Travier N, Olsen A, Tjønneland A, Overvad K, Rinaldi S, Romieu I, Brennan P, Boutron-Ruault M, Perquier F, Cadeau C, Boeing H, Aleksandrova K, Kaaks R, Kühn T, Trichopoulou A, Lagiou P, Trichopoulos D, Vineis P, Krogh V, Panico S, Masala G, Tumino R, Weiderpass E, Skeie G, Lund E, Quirós J, Ardanaz E, Navarro C, Amiano P, Sánchez M, Buckland G, Ericson U, Sonestedt E, Johansson M, Sund M, Travis R, Key T, Khaw K, Wareham N, Riboli E, van Gils C (2016) Plasma carotenoids, vitamin C, tocopherols, and retinol and the risk of breast cancer in the European Prospective Investigation into Cancer and Nutrition cohort. Am J Clin Nutr 103:454–464CrossRefPubMed
69.
Dorjgochoo T, Gao Y, Chow W, Shu X, Li H, Yang G, Cai Q, Rothman N, Cai H, Franke A, Zheng W, Dai Q (2009) Plasma carotenoids, tocopherols, retinol and breast cancer risk: results from the Shanghai Women Health Study (SWHS). Breast Cancer Res Treat 117:381–389CrossRefPubMed
70.
Epplein M, Shvetsov Y, Wilkens L, Franke A, Cooney R, Le Marchand L, Henderson B, Kolonel L, Goodman M (2009) Plasma carotenoids, retinol, and tocopherols and postmenopausal breast cancer risk in the Multiethnic Cohort Study: a nested case-control study. Breast Cancer Res 11:R49CrossRefPubMedPubMedCentral
71.
Sato R, Helzlsouer K, Alberg A, Hoffman S, Norkus E, Comstock G (2002) Prospective study of carotenoids, tocopherols, and retinoid concentrations and the risk of breast cancer. Cancer Epidemiol Biomarkers Prev 11:451–457PubMed
72.
Tamimi R, Hankinson S, Campos H, Spiegelman D, Zhang S, Colditz G, Willett W, Hunter D (2005) Plasma carotenoids, retinol, and tocopherols and risk of breast cancer. Am J Epidemiol 161:153–160CrossRefPubMed
73.
Kabat G, Kim M, Adams-Campbell L, Caan B, Chlebowski R, Neuhouser M, Shikany J, Rohan T, Investigators WHI (2009) Longitudinal study of serum carotenoid, retinol, and tocopherol concentrations in relation to breast cancer risk among postmenopausal women. Am J Clin Nutr 90:162–169CrossRefPubMedPubMedCentral
74.
de Lorgeril M, Salen P, Martin J, Boucher F, de Leiris J (2008) Interactions of wine drinking with omega-3 fatty acids in patients with coronary heart disease: a fish-like effect of moderate wine drinking. Am Heart J 155:175–181CrossRefPubMed
75.
di Giuseppe R, de Lorgeril M, Salen P, Laporte F, Di Castelnuovo A, Krogh V, Siani A, Arnout J, Cappuccio F, van Dongen M, Donati M, de Gaetano G, Iacoviello L, European Collaborative Group of the IMMIDIET Project (2009) Alcohol consumption and n-3 polyunsaturated fatty acids in healthy men and women from 3 European populations. Am J Clin Nutr 89:354–362CrossRef
76.
Schwingshackl L, Schwedhelm C, Galbete C, Hoffmann G (2017) Adherence to Mediterranean diet and risk of cancer: an updated systematic review and meta-analysis. Nutrients 9:E1063CrossRefPubMed
77.
Bassett J, Hodge A, English D, MacInnis R, Giles G (2016) Plasma phospholipids fatty acids, dietary fatty acids, and breast cancer risk. Cancer Causes Control 27:759–773CrossRefPubMed
78.
Chajès V, Assi N, Biessy C, Ferrari P, Rinaldi S, Slimani N, Lenoir G, Baglietto L, His M, Boutron-Ruault M, Trichopoulou A, Lagiou P, Katsoulis M, Kaaks R, Kühn T, Panico S, Pala V, Masala G, Bueno-de-Mesquita H, Peeters P, van Gils C, Hjartåker A, Standahl Olsen K, Borgund Barnung R, Barricarte A, Redondo-Sanchez D, Menéndez V, Amiano P, Wennberg M, Key T, Khaw K, Merritt M, Riboli E, Gunter M, Romieu I (2017) A prospective evaluation of plasma phospholipid fatty acids and breast cancer risk in the EPIC study. Ann Oncol 28:2836–2842CrossRefPubMed
79.
Pouchieu C, Chajès V, Laporte F, Kesse-Guyot E, Galan P, Hercberg S, Latino-Martel P, Touvier M (2014) Prospective associations between plasma saturated, monounsaturated and polyunsaturated fatty acids and overall and breast cancer risk - modulation by antioxidants: a nested case-control study. PLoS ONE 9:e90442CrossRefPubMedPubMedCentral
80.
Saadatian-Elahi M, Toniolo P, Ferrari P, Goudable J, Arslan A, Zeleniuch-Jacquotte A, Riboli E (2002) Serum fatty acids and risk of breast cancer in a nested case-control study of the New York University Women’s Health Study. Cancer Epidemiol Biomarkers Prev 11:1353–1360PubMed
81.
Kiyabu G, Inoue M, Saito E, Abe S, Sawada N, Ishihara J, Iwasaki M, Yamaji T, Shimazu T, Sasazuki S, Shibuya K, Tsugane S, JPHC Study Group (2015) Fish, n - 3 polyunsaturated fatty acids and n - 6 polyunsaturated fatty acids intake and breast cancer risk: the Japan Public Health Center-based prospective study. Int J Cancer 137:2915–2926CrossRef
82.
Sczaniecka A, Brasky T, Lampe J, Patterson R, White E (2012) Dietary intake of specific fatty acids and breast cancer risk among postmenopausal women in the VITAL cohort. Nutr Cancer 64:1131–1142CrossRefPubMedPubMedCentral
83.
Zheng JS, Hu XJ, Zhao YM, Yang J, Li D (2013) Intake of fish and marine n-3 polyunsaturated fatty acids and risk of breast cancer: meta-analysis of data from 21 independent prospective cohort studies. BMJ 346:f3706CrossRefPubMed
84.
Thompson F, Kirkpatrick S, Subar A, Reedy J, Schap T, Wilson M, Krebs-Smith S (2015) The National Cancer Institute's Dietary Assessment Primer: A resource for diet research. J Acad Nutr Diet 115:1986–1995CrossRefPubMedPubMedCentral
85.
Grundy S, Stone N, Bailey A, Beam C, Birtcher K, Blumenthal R, Braun L, de Ferranti S, Faiella-Tommasino J, Forman D, Goldberg R, Heidenreich P, Hlatky M, Jones D, Lloyd-Jones D, Lopez-Pajares N, Ndumele C, Orringer C, Peralta C, Saseen J, Smith SJ, Sperling L, Virani S, Yeboah J (2019) 2018 AHA/ACC/AACVPR/AAPA/ABC/ACPM/ADA/AGS/APhA/ASPC/NLA/PCNA Guideline on the management of blood cholesterol: executive summary. Circulation 139:e1046–1081PubMed
86.
Nelson D, Naimi T, Brewer R, Roeber J (2010) US state alcohol sales compared to survey data, 1993–2006. Addiction 105:1589–1596CrossRefPubMed
87.
Key T, Appleby P, Barnes I, Reeves G (2002) Endogenous sex hormones and breast cancer in postmenopausal women: reanalysis of nine prospective studies. J Natl Cancer Inst 94:606–616CrossRefPubMed
88.
Dorgan JF, Baer DJ, Albert PS, Judd JT, Brown ED, Corle DK, Campbell WS, Hartman TJ, Tejpar AA, Clevidence BA, Giffen CA, Chandler DW, Stanczyk FZ, Taylor PR (2001) Serum hormones and the alcohol-breast cancer association in postmenopausal women. J Natl Cancer Inst 93:710–715CrossRefPubMed
89.
Hirko K, Spiegelman D, Willett W, Hankinson S, Eliassen A (2014) Alcohol consumption in relation to plasma sex hormones, prolactin, and sex hormone-binding globulin in premenopausal women. Cancer Epidemiol Biomarkers and Prev 23:2943–2953CrossRef
90.
Key TJ, Appleby PN, Reeves GK, Roddam AW, Helzlsouer KJ, Alberg AJ, Rollison DE, Dorgan JF, Brinton LA, Overvad K, Kaaks R, Trichopoulou A, Clavel-Chapelon F, Panico S, Duell EJ, Peeters PH, Rinaldi S, Fentiman IS, Dowsett M, Manjer J, Lenner P, Hallmans G, Baglietto L, English DR, Giles GG, Hopper JL, Severi G, Morris HA, Hankinson SE, Tworoger SS, Koenig K, Zeleniuch-Jacquotte A, Arslan AA, Toniolo P, Shore RE, Krogh V, Micheli A, Berrino F, Barrett-Connor E, Laughlin GA, Kabuto M, Akiba S, Stevens RG, Neriishi K, Land CE, Cauley JA, Lui LY, Cummings SR, Gunter MJ, Rohan TE, Strickler HD (2011) Circulating sex hormones and breast cancer risk factors in postmenopausal women: reanalysis of 13 studies. Br J Cancer 105:709–722CrossRefPubMed
91.
Reichman ME, Judd JT, Longcope C, Schatzkin A, Clevidence BA, Nair PP, Campbell WS, Taylor PR (1993) Effects of alcohol consumption on plasma and urinary hormone concentrations in premenopausal women. J Natl Cancer Inst 85:722–727CrossRefPubMed
92.
Rinaldi S, Peeters P, Bezemer I, Dossus L, Biessy C, Sacerdote C, Berrino F, Panico S, Palli D, Tumino R, Khaw K, Bingham S, Allen N, Key T, Jensen M, Overvad K, Olsen A, Tjonneland A, Amiano P, Ardanaz E, Agudo A, Martinez-Garcia C, Quiros J, Tormo M, Nagel G, Linseisen J, Boeing H, Schulz M, Grobbee D, Bueno-de-Mesquita H, Koliva M, Kyriazi G, Thrichooulou A, Boutron-Ruault M, Clavel-Chapelon F, Ferrari P, Slimani N, Saracci R, Riboli E, Kaaks R (2006) Relationship of alcohol intake and sex steroid concentrations in blood in pre- and post-menopausal women: the European Prospective Investigation into Cancer and Nutrition. Cancer Causes Control 17:1033–1043CrossRefPubMed
Metadata
Title
Alcohol consumption and serum metabolite concentrations in young women
Authors
Joanne F. Dorgan
Seungyoun Jung
Cher M. Dallal
Min Zhan
Christina A. Stennett
Yuji Zhang
Richard L. Eckert
Linda G. Snetselaar
Linda Van Horn
Publication date
01-02-2020
Publisher
Springer International Publishing
Published in
Cancer Causes & Control / Issue 2/2020
Print ISSN: 0957-5243
Electronic ISSN: 1573-7225
DOI
https://doi.org/10.1007/s10552-019-01256-1

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