Skip to main content
Top
Published in: Experimental Brain Research 3/2013

01-09-2013 | Volition

Break in volition: a virtual reality study in patients with obsessive-compulsive disorder

Authors: Pietro Cipresso, Filippo La Paglia, Caterina La Cascia, Giuseppe Riva, Giovanni Albani, Daniele La Barbera

Published in: Experimental Brain Research | Issue 3/2013

Login to get access

Abstract

Research in obsessive-compulsive disorder (OCD) produced inconsistent results in demonstrating an association between patients’ symptom severity and their cognitive impairments. The process involved in volition aspects of behavioral syndromes can be extensively analyzed using specific tests developed in virtual environments, more suitable to manipulate rules and possible breaks of the normal task execution with different, confusing or stopping instructions. The study involved thirty participants (15 OCD patients and 15 controls) during task execution and the relative interferences. At this purpose, the virtual version of Multiple Errands Test was used. Virtual reality setting, with a higher ecological validity respect to a classic neuropsychological battery, allowed us to take into account deficits of volition and the relative dysexecutive functions associated with OCD patients. The proposed paradigm also allows the development of innovative prototypes of coevolving technologies based on new theories and models and deeper understanding of human behavior.
Literature
go back to reference Abramovitch A, Dar R, Schweiger A, Hermesh H (2011) Neuropsychological impairments and their association with obsessive-compulsive symptom severity in obsessive-compulsive disorder. Arch Clin Neuropsych 26(4):364–376. doi:10.1093/arclin/acr022 CrossRef Abramovitch A, Dar R, Schweiger A, Hermesh H (2011) Neuropsychological impairments and their association with obsessive-compulsive symptom severity in obsessive-compulsive disorder. Arch Clin Neuropsych 26(4):364–376. doi:10.​1093/​arclin/​acr022 CrossRef
go back to reference Albani G, Cipresso P, Gaggioli A, Serino S, Vigna C, Priano L, Mauro A, Franzini A, Riva G (2012) Virtual help for real surgery: the case of awake surgery. Stud Health Technol Inform 173:13–15PubMed Albani G, Cipresso P, Gaggioli A, Serino S, Vigna C, Priano L, Mauro A, Franzini A, Riva G (2012) Virtual help for real surgery: the case of awake surgery. Stud Health Technol Inform 173:13–15PubMed
go back to reference Burdea G, Richard P, Coiffet P (1996) Multimodal virtual reality: input-output devices, system integration, and human factors. Int J Hum Comput Interact 8(1):5–24CrossRef Burdea G, Richard P, Coiffet P (1996) Multimodal virtual reality: input-output devices, system integration, and human factors. Int J Hum Comput Interact 8(1):5–24CrossRef
go back to reference Burgess PW, Alderman N, Forbes C, Costello A, Coates LMA, Dawson DR, Anderson ND, Gilbert SJ, Dumontheil I, Channon S (2006) The case for the development and use of “ecologically valid” measures of executive function in experimental and clinical neuropsychology. J Int Neuropsychol Soc 12:194–209PubMedCrossRef Burgess PW, Alderman N, Forbes C, Costello A, Coates LMA, Dawson DR, Anderson ND, Gilbert SJ, Dumontheil I, Channon S (2006) The case for the development and use of “ecologically valid” measures of executive function in experimental and clinical neuropsychology. J Int Neuropsychol Soc 12:194–209PubMedCrossRef
go back to reference Carelli L, Morganti F, Poletti B, Corra B, Weiss PL, Kizony R, Silani V, Riva G (2009) A NeuroVR based tool for cognitive assessment and rehabilitation of post-stroke patients: two case studies. Stud Health Technol 144:243–247. doi:10.3233/978-1-60750-017-9-243 Carelli L, Morganti F, Poletti B, Corra B, Weiss PL, Kizony R, Silani V, Riva G (2009) A NeuroVR based tool for cognitive assessment and rehabilitation of post-stroke patients: two case studies. Stud Health Technol 144:243–247. doi:10.​3233/​978-1-60750-017-9-243
go back to reference Chamberlain SR, Blackwell AD, Fineberg NA, Robbins TW, Sahakian J (2005) The neuropsychology of obsessive compulsive disorder: the importance of failures in cognitive and behavioural inhibition as candidate endophenotypic markers. Neurosci Biobehav R 29(3):399–419. doi:10.1016/j.neubiorev.2004.11.006 CrossRef Chamberlain SR, Blackwell AD, Fineberg NA, Robbins TW, Sahakian J (2005) The neuropsychology of obsessive compulsive disorder: the importance of failures in cognitive and behavioural inhibition as candidate endophenotypic markers. Neurosci Biobehav R 29(3):399–419. doi:10.​1016/​j.​neubiorev.​2004.​11.​006 CrossRef
go back to reference Chamberlain SR, Menzies L, Hampshire A, Suckling J, Fineberg NA, del Campo N, Aitken M, Craig K, Owen AM, Bullmore ET, Robbins TW, Sahakian BJ (2008) Orbitofrontal dysfunction in patients with obsessive-compulsive disorder and their unaffected relatives. Science 321(5887):421–422. doi:10.1126/science.1154433 PubMedCrossRef Chamberlain SR, Menzies L, Hampshire A, Suckling J, Fineberg NA, del Campo N, Aitken M, Craig K, Owen AM, Bullmore ET, Robbins TW, Sahakian BJ (2008) Orbitofrontal dysfunction in patients with obsessive-compulsive disorder and their unaffected relatives. Science 321(5887):421–422. doi:10.​1126/​science.​1154433 PubMedCrossRef
go back to reference Chan RCK, Shum D, Toulopoulou T, Chen EYH (2008) Assessment of executive functions: Review of instruments and identification of critical issues. Arch Clin Neuropsychol 23:201–216PubMedCrossRef Chan RCK, Shum D, Toulopoulou T, Chen EYH (2008) Assessment of executive functions: Review of instruments and identification of critical issues. Arch Clin Neuropsychol 23:201–216PubMedCrossRef
go back to reference Cipresso P, Raspelli S, Pallavicini F, Grassi A, Balgera A, Gaggioli A, Villamira M, Albani G, Mauro A, Riva G (2011) Investigations of executive functions using Virtual Multiple Errands Test and Psychophysiological measures. J CyberTher Rehabil 4(2):259–260 Cipresso P, Raspelli S, Pallavicini F, Grassi A, Balgera A, Gaggioli A, Villamira M, Albani G, Mauro A, Riva G (2011) Investigations of executive functions using Virtual Multiple Errands Test and Psychophysiological measures. J CyberTher Rehabil 4(2):259–260
go back to reference Cipresso P, Gaggioli A, Serino S, Cipresso S, Riva G (2012) How to Create Memorizable and Strong Passwords. J Med Internet Res 14(1). doi:DOI 10.2196/jmir.1906 Cipresso P, Gaggioli A, Serino S, Cipresso S, Riva G (2012) How to Create Memorizable and Strong Passwords. J Med Internet Res 14(1). doi:DOI 10.​2196/​jmir.​1906
go back to reference DSM-IV. APATFo (2000) Diagnostic and statistical manual of mental disorders : DSM-IV-TR, 4th edn. American Psychiatric Association, Washington DSM-IV. APATFo (2000) Diagnostic and statistical manual of mental disorders : DSM-IV-TR, 4th edn. American Psychiatric Association, Washington
go back to reference El Emam K, Moreau K, Jonker E (2011) How strong are passwords used to protect personal health information in clinical trials? J Med Internet Res 13(1):13–22. doi:10.2196/jmir.1335 CrossRef El Emam K, Moreau K, Jonker E (2011) How strong are passwords used to protect personal health information in clinical trials? J Med Internet Res 13(1):13–22. doi:10.​2196/​jmir.​1335 CrossRef
go back to reference Fineberg NA, Chamberlain S, Blackwell A, Sahakian BJ, Robbins TW (2005) Exploring neurocognitive endophenotypes of obsessive compulsive spectrum disorders using tests of cognitive and motor inhibition. Eur Neuropsychopharm 15:S529–S529 Fineberg NA, Chamberlain S, Blackwell A, Sahakian BJ, Robbins TW (2005) Exploring neurocognitive endophenotypes of obsessive compulsive spectrum disorders using tests of cognitive and motor inhibition. Eur Neuropsychopharm 15:S529–S529
go back to reference Fineberg N, Chamberlain SR, Menzies LA, Craig K, Morein-Zamir S, Sahakian BJ, Robbins TW, Bullmore ET (2008) Neuropsychological endophenotypes in families with OCD. Eur Neuropsychopharm 18:S166–S167CrossRef Fineberg N, Chamberlain SR, Menzies LA, Craig K, Morein-Zamir S, Sahakian BJ, Robbins TW, Bullmore ET (2008) Neuropsychological endophenotypes in families with OCD. Eur Neuropsychopharm 18:S166–S167CrossRef
go back to reference Goldstein G (1996) Functional considerations in neuropsychology. In: Sbordone RJ, Long CJ (eds) Ecological validity of neuropsychological testing. GR Press/St. Lucie Press, Delray Beach, Florida, pp 75–89 Goldstein G (1996) Functional considerations in neuropsychology. In: Sbordone RJ, Long CJ (eds) Ecological validity of neuropsychological testing. GR Press/St. Lucie Press, Delray Beach, Florida, pp 75–89
go back to reference Heeter C (1992) Being there: the subjective experience of presence. Presence: teleoperators and virtual environments 1(2):262–271 Heeter C (1992) Being there: the subjective experience of presence. Presence: teleoperators and virtual environments 1(2):262–271
go back to reference Mantovani G, Riva G (1999) “Real” presence: how different ontologies generate different criteria for presence, telepresence, and virtual presence. Presence Teleoper Virtual Environ 8(5):538–548CrossRef Mantovani G, Riva G (1999) “Real” presence: how different ontologies generate different criteria for presence, telepresence, and virtual presence. Presence Teleoper Virtual Environ 8(5):538–548CrossRef
go back to reference Mantovani G, Riva G (2001) Building a bridge between different scientific communities: on Sheridan’s eclectic ontology of presence. Presence: Teleoper Virtual Environ 8:538–548 Mantovani G, Riva G (2001) Building a bridge between different scientific communities: on Sheridan’s eclectic ontology of presence. Presence: Teleoper Virtual Environ 8:538–548
go back to reference Menzies L, Williams GB, Chamberlain SR, Ooi C, Fineberg N, Suckling J, Sahakian BJ, Robbins TW, Bullmore ET (2008) White matter abnormalities in patients with obsessive-compulsive disorder and their first-degree relatives. Am J Psychiat 165(10):1308–1315. doi:10.1176/appi.ajp.2008.07101677 PubMedCrossRef Menzies L, Williams GB, Chamberlain SR, Ooi C, Fineberg N, Suckling J, Sahakian BJ, Robbins TW, Bullmore ET (2008) White matter abnormalities in patients with obsessive-compulsive disorder and their first-degree relatives. Am J Psychiat 165(10):1308–1315. doi:10.​1176/​appi.​ajp.​2008.​07101677 PubMedCrossRef
go back to reference Morein-Zamir S, Craig KJ, Ersche KD, Abbott S, Muller U, Fineberg NA, Bullmore ET, Sahakian BJ, Robbins TW (2010a) Impaired visuospatial associative memory and attention in obsessive compulsive disorder but no evidence for differential dopaminergic modulation. Psychopharmacology 212(3):357–367. doi:10.1007/s00213-010-1963-z PubMedCrossRef Morein-Zamir S, Craig KJ, Ersche KD, Abbott S, Muller U, Fineberg NA, Bullmore ET, Sahakian BJ, Robbins TW (2010a) Impaired visuospatial associative memory and attention in obsessive compulsive disorder but no evidence for differential dopaminergic modulation. Psychopharmacology 212(3):357–367. doi:10.​1007/​s00213-010-1963-z PubMedCrossRef
go back to reference Pallavicini F, Cipresso P, Raspelli S, Grassi A, Serino S, Vigna C, Triberti S, Villamira M, Gaggioli A, Riva G (2013) Is virtual reality always an effective stressors for exposure treatments? Some insights from a controlled trial. BMC Psychiatry 13:52. doi:10.1186/1471-244X-13-52 PubMedCrossRef Pallavicini F, Cipresso P, Raspelli S, Grassi A, Serino S, Vigna C, Triberti S, Villamira M, Gaggioli A, Riva G (2013) Is virtual reality always an effective stressors for exposure treatments? Some insights from a controlled trial. BMC Psychiatry 13:52. doi:10.​1186/​1471-244X-13-52 PubMedCrossRef
go back to reference Rand D, Rukan SB, Weiss PL, Katz N (2009) Validation of the virtual MET as an assessment tool for executive functions. Neuropsychol Rehabil 19(4):583–602PubMedCrossRef Rand D, Rukan SB, Weiss PL, Katz N (2009) Validation of the virtual MET as an assessment tool for executive functions. Neuropsychol Rehabil 19(4):583–602PubMedCrossRef
go back to reference Raspelli S, Carelli L, Morganti F, Riva G, Weiss PL, Kizony R, Katz N (2009) Implementation of the Multiple Errand Test in a NeuroVR-supermarket. Virtual rehabilitation international conference, p 210 Raspelli S, Carelli L, Morganti F, Riva G, Weiss PL, Kizony R, Katz N (2009) Implementation of the Multiple Errand Test in a NeuroVR-supermarket. Virtual rehabilitation international conference, p 210
go back to reference Raspelli S, Carelli L, Morganti F, Poletti B, Corra B, Silani V, Riva G (2010) Implementation of the multiple errands test in a NeuroVR-supermarket: a possible approach. Stud Health Technol Informa 154:115–119 Raspelli S, Carelli L, Morganti F, Poletti B, Corra B, Silani V, Riva G (2010) Implementation of the multiple errands test in a NeuroVR-supermarket: a possible approach. Stud Health Technol Informa 154:115–119
go back to reference Raspelli S, Pallavicini F, Carelli L, Morganti F, Pedroli E, Cipresso P, Poletti B, Corra B, Sangalli D, Silani V, Riva G (2012) Validating the neuro VR-based virtual version of the multiple errands test: preliminary results. Presence-Teleop Virt 21(1):31–42 Raspelli S, Pallavicini F, Carelli L, Morganti F, Pedroli E, Cipresso P, Poletti B, Corra B, Sangalli D, Silani V, Riva G (2012) Validating the neuro VR-based virtual version of the multiple errands test: preliminary results. Presence-Teleop Virt 21(1):31–42
go back to reference Repetto C, Gaggioli A, Pallavicini F, Cipresso P, Raspelli S, Riva G (2013) Virtual reality and mobile phones in the treatment of generalized anxiety disorders: a phase-2 clinical trial. Pers Ubiquit Comput 17(2):253–260. doi:10.1007/s00779-011-0467-0 CrossRef Repetto C, Gaggioli A, Pallavicini F, Cipresso P, Raspelli S, Riva G (2013) Virtual reality and mobile phones in the treatment of generalized anxiety disorders: a phase-2 clinical trial. Pers Ubiquit Comput 17(2):253–260. doi:10.​1007/​s00779-011-0467-0 CrossRef
go back to reference Riva G, Gaggioli A, Grassi A, Raspelli S, Cipresso P, Pallavicini F, Vigna C, Gagliati A, Gasco S, Donvito G (2011) NeuroVR 2–a free virtual reality platform for the assessment and treatment in behavioral health care. Stud Health Technol Inform 163:493–495PubMed Riva G, Gaggioli A, Grassi A, Raspelli S, Cipresso P, Pallavicini F, Vigna C, Gagliati A, Gasco S, Donvito G (2011) NeuroVR 2–a free virtual reality platform for the assessment and treatment in behavioral health care. Stud Health Technol Inform 163:493–495PubMed
go back to reference Sbordone RJ (1996) Ecological validity: Some critical issues for neuropsychologist. In: Sbordone RJ, Long CJ (eds) Ecological validity of neuropsychological testing. GR Press/St. Lucie Press, Delray Beach, Florida, pp 15–41 Sbordone RJ (1996) Ecological validity: Some critical issues for neuropsychologist. In: Sbordone RJ, Long CJ (eds) Ecological validity of neuropsychological testing. GR Press/St. Lucie Press, Delray Beach, Florida, pp 15–41
go back to reference Schultheis MT, Himelstein J, Rizzo AA (2002) Virtual reality and neuropsychology: upgrading the current tools. J Head Trauma Rehabil 17(5):378–394PubMedCrossRef Schultheis MT, Himelstein J, Rizzo AA (2002) Virtual reality and neuropsychology: upgrading the current tools. J Head Trauma Rehabil 17(5):378–394PubMedCrossRef
go back to reference Shallice T, Burgess PW (1991) Deficits in strategy application following frontal lobe damage in man. Brain 114(Pt 2):727–741PubMedCrossRef Shallice T, Burgess PW (1991) Deficits in strategy application following frontal lobe damage in man. Brain 114(Pt 2):727–741PubMedCrossRef
go back to reference Slater M, Steed A, Chrysanthou Y (2002) Computer graphics and virtual environments: from realism to real-time. Pearson Harlow, Essex Slater M, Steed A, Chrysanthou Y (2002) Computer graphics and virtual environments: from realism to real-time. Pearson Harlow, Essex
go back to reference Slater M, Lotto B, Arnold MM, Sanchez-Vives MV (2009a) How we experience immersive virtual environments: the concept of presence and its measurement. Anuario de Psicología 40(2):193–210 Slater M, Lotto B, Arnold MM, Sanchez-Vives MV (2009a) How we experience immersive virtual environments: the concept of presence and its measurement. Anuario de Psicología 40(2):193–210
Metadata
Title
Break in volition: a virtual reality study in patients with obsessive-compulsive disorder
Authors
Pietro Cipresso
Filippo La Paglia
Caterina La Cascia
Giuseppe Riva
Giovanni Albani
Daniele La Barbera
Publication date
01-09-2013
Publisher
Springer Berlin Heidelberg
Published in
Experimental Brain Research / Issue 3/2013
Print ISSN: 0014-4819
Electronic ISSN: 1432-1106
DOI
https://doi.org/10.1007/s00221-013-3471-y

Other articles of this Issue 3/2013

Experimental Brain Research 3/2013 Go to the issue