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10-11-2023 | Brain Tumor | Original Article

Prevalence, characteristics, and risk factors of venous thromboembolism in patients with brain tumor undergoing craniotomy: a meta-analysis

Authors: Qingping Zeng, Guangyu Lu, Jing Yuan, Jiali Ding, Juan Chen, Xianru Gao, Yujia Huang, Tian Shi, Hailong Yu, Hongbin Ni, Yuping Li

Published in: Neurological Sciences | Issue 4/2024

Abstract

Background

Brain tumor patients undergoing craniotomy are significantly associated with the development of venous thromboembolism (VTE), while the contributing factors remains controversial. Our study aimed to investigate the prevalence and risk factors for VTE in postoperational brain tumor patients.

Methods

We searched the PubMed, Embase, Web of Science, Medline, and Cochrane Library databases from their inception to July 2023. Article selection, data extraction, and study quality assessment were performed independently by two reviewers. Publication bias was assessed using Egger’s and Begg’s tests. Stata 15.0 software was used for data analysis.

Results

A total of 25 studies were considered, with a total of 49,620 brain tumor individuals. The pooled prevalence of VTE during hospitalization in postoperational brain tumor patients was 9% [95% CI: (0.08, 0.10)]. Moreover, our results demonstrated that patients with VTE were older than those without VTE [mean difference [MD] = 8.14, 95% CI: (4.97, 11.30)]. The following variables were significantly associated with VTE: prior history of VTE [OR = 7.81, 95% CI: (3.62, 16.88)], congestive heart failure [OR = 2.33, 95% CI: (1.08–5.05)], diabetes [OR = 1.87, 95% CI: (1.12–3.10)], hypertension [OR = 1.27, 95% CI: (1.07–1.50)], steroid use [OR = 1.63, 95% CI: (1.41, 1.88)], high white blood cells counts [MD = 0.32, 95% CI: (0.01, 0.63)], and high fibrinogen levels [MD = 0.19, 95% CI: (0.08, 0.30)].

Conclusion

This meta-analysis identified risk factors for postoperational VTE in patients with brain tumor, which can serve as a theoretical foundation for medical staff to manage and treat VTE.

Trial registration

CRD42023357459

Available only for authorised users

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Title: Prevalence, characteristics, and risk factors of venous thromboembolism in patients with brain tumor undergoing craniotomy: a meta-analysis
Authors: Qingping Zeng
Guangyu Lu
Jing Yuan
Jiali Ding
Juan Chen
Xianru Gao
Yujia Huang
Tian Shi
Hailong Yu
Hongbin Ni
Yuping Li
Publication date: 10-11-2023
Publisher: Springer International Publishing
Keywords: Brain Tumor
Craniotomy
Glioma
Glioma
Glioma
Published in: Neurological Sciences / Issue 4/2024
Print ISSN: 1590-1874
Electronic ISSN: 1590-3478
DOI: https://doi.org/10.1007/s10072-023-07160-6

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Prevalence, characteristics, and risk factors of venous thromboembolism in patients with brain tumor undergoing craniotomy: a meta-analysis

Abstract

Background

Methods

Results

Conclusion

Trial registration

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Methods

Results

Conclusion

Trial registration

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