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01-10-2017 | Short Paper

Brain microstructural alterations in patients with severe obstructive sleep apnea: a preliminary diffusion tensor imaging study

Authors: Masaki Nakamura, Mariko Yanagihara, Kentaro Matsui, Mina Kobayashi, Yuichi Inoue

Published in: Sleep and Biological Rhythms | Issue 4/2017

Abstract

We applied a neuroimaging analysis to investigate the association between neurocognitive decline and brain structural changes in patients with OSAS. Nineteen male patients with severe OSAS were enrolled. Correlations between sleep-breathing indices and microstructural changes were analyzed. SpO₂ was positively correlated with ADC, FA, and white matter volumes in frontal areas, cingulate, anterior cerebellar lobe, and pons. A positive correlation with gray matter volume was identified in the bilateral parahippocampal gyri. Neurocognitive decline also correlated with minimum SpO₂ value. Intermittent hypoxia in OSAS may cause microstructural axonal changes. These alterations may underlie executive dysfunction in OSAS.

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Title: Brain microstructural alterations in patients with severe obstructive sleep apnea: a preliminary diffusion tensor imaging study
Authors: Masaki Nakamura
Mariko Yanagihara
Kentaro Matsui
Mina Kobayashi
Yuichi Inoue
Publication date: 01-10-2017
Publisher: Springer Japan
Published in: Sleep and Biological Rhythms / Issue 4/2017
Print ISSN: 1446-9235
Electronic ISSN: 1479-8425
DOI: https://doi.org/10.1007/s41105-017-0113-y

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Springer Medicine

Brain microstructural alterations in patients with severe obstructive sleep apnea: a preliminary diffusion tensor imaging study

Abstract

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

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