Skip to main content
Top
Published in: Aesthetic Plastic Surgery 1/2022

01-02-2022 | Brachytherapy | Review

Adjuvant Radiotherapy for Keloids

Authors: Wenfang Dong, Bin Qiu, Fei Fan

Published in: Aesthetic Plastic Surgery | Issue 1/2022

Login to get access

Abstract

Radiotherapy is one of the therapeutic methods for keloids, and the irradiation technique has innovated from superficial X-ray to brachytherapy after decades of clinical practice. At present, the application of adjuvant radiotherapy has been widely accepted by clinicians, while the consensus of optimal adjuvant radiotherapy strategies for keloids has not been reached. Factors such as radiation timing, dose, fractions, and lesion locations may be associated with the clinical outcomes of patients with keloids after radiotherapy while a comprehensive review is lacking. Herein, this review summarized the published literature of adjuvant radiotherapy for keloids involving mechanism, timing, dose, fractions, and complications, etc., which may facilitate clinical decision making.
Level of Evidence III This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.​springer.​com/​00266.
Literature
1.
go back to reference Flickinger JC (2011) A radiobiological analysis of multicenter data for postoperative keloid radiotherapy. Int J Radiat Oncol Biol Phys 79:1164–1170PubMedCrossRef Flickinger JC (2011) A radiobiological analysis of multicenter data for postoperative keloid radiotherapy. Int J Radiat Oncol Biol Phys 79:1164–1170PubMedCrossRef
2.
go back to reference Li W, Wang Y, Wang X, Liu Z (2014) A keloid edge precut, preradiotherapy method in large keloid skin graft treatment. Dermatol Surg 40:52–57PubMedCrossRef Li W, Wang Y, Wang X, Liu Z (2014) A keloid edge precut, preradiotherapy method in large keloid skin graft treatment. Dermatol Surg 40:52–57PubMedCrossRef
3.
go back to reference Brown JJ, Bayat A (2009) Genetic susceptibility to raised dermal scarring. Br J Dermatol 161:8–18PubMedCrossRef Brown JJ, Bayat A (2009) Genetic susceptibility to raised dermal scarring. Br J Dermatol 161:8–18PubMedCrossRef
5.
go back to reference Hoang D, Reznik R, Orgel M et al (2017) Surgical excision and adjuvant brachytherapy vs external beam radiation for the effective treatment of keloids: 10-year institutional retrospective analysis. Aesthet Surg J 37:212–225PubMedCrossRef Hoang D, Reznik R, Orgel M et al (2017) Surgical excision and adjuvant brachytherapy vs external beam radiation for the effective treatment of keloids: 10-year institutional retrospective analysis. Aesthet Surg J 37:212–225PubMedCrossRef
6.
go back to reference Mankowski P, Kanevsky J, Tomlinson J et al (2017) Optimizing radiotherapy for keloids: a meta-analysis systematic review comparing recurrence rates between different radiation modalities. Ann Plast Surg 78:403–411PubMedCrossRef Mankowski P, Kanevsky J, Tomlinson J et al (2017) Optimizing radiotherapy for keloids: a meta-analysis systematic review comparing recurrence rates between different radiation modalities. Ann Plast Surg 78:403–411PubMedCrossRef
7.
go back to reference Mustoe TA, Cooter RD, Gold MH et al (2002) International clinical recommendations on scar management. Plast Reconstr Surg 110:560–571PubMedCrossRef Mustoe TA, Cooter RD, Gold MH et al (2002) International clinical recommendations on scar management. Plast Reconstr Surg 110:560–571PubMedCrossRef
8.
go back to reference Ogawa R (2010) The most current algorithms for the treatment and prevention of hypertrophic scars and keloids. Plast Reconstr Surg 125:557–568PubMedCrossRef Ogawa R (2010) The most current algorithms for the treatment and prevention of hypertrophic scars and keloids. Plast Reconstr Surg 125:557–568PubMedCrossRef
9.
go back to reference Craig RD, Pearson D (1965) Early post-operative irradiation in the treatment of keloid scars. Br J Plast Surg 18:369–376PubMedCrossRef Craig RD, Pearson D (1965) Early post-operative irradiation in the treatment of keloid scars. Br J Plast Surg 18:369–376PubMedCrossRef
10.
go back to reference Inalsingh CH (1974) An experience in treating five hundred and one patients with keloids. Johns Hopkins Med J 134:284–290PubMed Inalsingh CH (1974) An experience in treating five hundred and one patients with keloids. Johns Hopkins Med J 134:284–290PubMed
11.
go back to reference Levy DS, Salter MM, Roth RE (1976) Postoperative irradiation in the prevention of keloids. AJR Am J Roentgenol 127:509–510PubMedCrossRef Levy DS, Salter MM, Roth RE (1976) Postoperative irradiation in the prevention of keloids. AJR Am J Roentgenol 127:509–510PubMedCrossRef
12.
13.
go back to reference Ship AG, Weiss PR, Mincer FR, Wolkstein W (1993) Sternal keloids: successful treatment employing surgery and adjunctive radiation. Ann Plast Surg 31:481–487PubMedCrossRef Ship AG, Weiss PR, Mincer FR, Wolkstein W (1993) Sternal keloids: successful treatment employing surgery and adjunctive radiation. Ann Plast Surg 31:481–487PubMedCrossRef
14.
go back to reference Ogawa R, Mitsuhashi K, Hyakusoku H, Miyashita T (2003) Postoperative electron-beam irradiation therapy for keloids and hypertrophic scars: retrospective study of 147 cases followed for more than 18 months. Plast Reconstr Surg 111:547–553PubMed Ogawa R, Mitsuhashi K, Hyakusoku H, Miyashita T (2003) Postoperative electron-beam irradiation therapy for keloids and hypertrophic scars: retrospective study of 147 cases followed for more than 18 months. Plast Reconstr Surg 111:547–553PubMed
15.
go back to reference Al-Attar A, Mess S, Thomassen JM et al (2006) Keloid pathogenesis and treatment. Plast Reconstr Surg 117:286–300PubMedCrossRef Al-Attar A, Mess S, Thomassen JM et al (2006) Keloid pathogenesis and treatment. Plast Reconstr Surg 117:286–300PubMedCrossRef
16.
go back to reference Lin YF, Shueng PW, Roan TL et al (2020) Tomotherapy as an alternative irradiative treatment for complicated keloids. J Clin Med 9:3732PubMedCentralCrossRef Lin YF, Shueng PW, Roan TL et al (2020) Tomotherapy as an alternative irradiative treatment for complicated keloids. J Clin Med 9:3732PubMedCentralCrossRef
17.
go back to reference Akinbiyi T, Kozak GM, Davis HD et al (2021) Contemporary treatment of keloids: a 10-year institutional experience with medical management, surgical excision, and radiation therapy. Am J Surg 221:689–696PubMedCrossRef Akinbiyi T, Kozak GM, Davis HD et al (2021) Contemporary treatment of keloids: a 10-year institutional experience with medical management, surgical excision, and radiation therapy. Am J Surg 221:689–696PubMedCrossRef
18.
go back to reference Wang Y, Ma J, Zhang Z, Shen H (2020) Combined surgical excision and electron external beam radiation improves the treatment of keloids: a descriptive study. Dermatol Ther 33:e13494PubMedCrossRef Wang Y, Ma J, Zhang Z, Shen H (2020) Combined surgical excision and electron external beam radiation improves the treatment of keloids: a descriptive study. Dermatol Ther 33:e13494PubMedCrossRef
20.
go back to reference Jones ME, Ganzer CA, Bennett D, Finizio A (2019) Surgical excision of keloids followed by in-office superficial radiation therapy: prospective study examining clinical outcomes. Plast Reconstr Surg Glob Open 7:e2212PubMedPubMedCentralCrossRef Jones ME, Ganzer CA, Bennett D, Finizio A (2019) Surgical excision of keloids followed by in-office superficial radiation therapy: prospective study examining clinical outcomes. Plast Reconstr Surg Glob Open 7:e2212PubMedPubMedCentralCrossRef
21.
go back to reference Liu CL, Yuan ZY (2019) Retrospective study of immediate postoperative electron radiotherapy for therapy-resistant earlobe keloids. Arch Dermatol Res 311:469–475PubMedPubMedCentralCrossRef Liu CL, Yuan ZY (2019) Retrospective study of immediate postoperative electron radiotherapy for therapy-resistant earlobe keloids. Arch Dermatol Res 311:469–475PubMedPubMedCentralCrossRef
22.
go back to reference Hsueh WT, Hung KS, Chen YC et al (2019) Adjuvant radiotherapy after keloid excision: preliminary experience in taiwan. Ann Plast Surg 82:S39–S44PubMedCrossRef Hsueh WT, Hung KS, Chen YC et al (2019) Adjuvant radiotherapy after keloid excision: preliminary experience in taiwan. Ann Plast Surg 82:S39–S44PubMedCrossRef
24.
go back to reference Sruthi K, Chelakkot PG, Madhavan R et al (2018) Single-fraction radiation: a promising adjuvant therapy to prevent keloid recurrence. J Cancer Res Ther 14:1251–1255PubMed Sruthi K, Chelakkot PG, Madhavan R et al (2018) Single-fraction radiation: a promising adjuvant therapy to prevent keloid recurrence. J Cancer Res Ther 14:1251–1255PubMed
25.
go back to reference Renz P, Hasan S, Gresswell S et al (2018) Dose effect in adjuvant radiation therapy for the treatment of resected keloids. Int J Radiat Oncol Biol Phys 102:149–154PubMedPubMedCentralCrossRef Renz P, Hasan S, Gresswell S et al (2018) Dose effect in adjuvant radiation therapy for the treatment of resected keloids. Int J Radiat Oncol Biol Phys 102:149–154PubMedPubMedCentralCrossRef
26.
go back to reference Shen J, Lian X, Sun Y et al (2015) Hypofractionated electron-beam radiation therapy for keloids: retrospective study of 568 cases with 834 lesions. J Radiat Res 56:811–817PubMedPubMedCentralCrossRef Shen J, Lian X, Sun Y et al (2015) Hypofractionated electron-beam radiation therapy for keloids: retrospective study of 568 cases with 834 lesions. J Radiat Res 56:811–817PubMedPubMedCentralCrossRef
27.
go back to reference Lee SY, Park J (2015) Postoperative electron beam radiotherapy for keloids: treatment outcome and factors associated with occurrence and recurrence. Ann Dermatol 27:53–58PubMedPubMedCentralCrossRef Lee SY, Park J (2015) Postoperative electron beam radiotherapy for keloids: treatment outcome and factors associated with occurrence and recurrence. Ann Dermatol 27:53–58PubMedPubMedCentralCrossRef
28.
go back to reference Wang LZ, Ding JP, Yang MY, Chen B (2014) Forty-five cases of chest keloids treated with subcutaneous super-tension-reduction suture combined with postoperative electron-beam irradiation. Dermatol Surg 40:1378–1384PubMedCrossRef Wang LZ, Ding JP, Yang MY, Chen B (2014) Forty-five cases of chest keloids treated with subcutaneous super-tension-reduction suture combined with postoperative electron-beam irradiation. Dermatol Surg 40:1378–1384PubMedCrossRef
29.
30.
go back to reference Yamawaki S, Naitoh M, Ishiko T et al (2011) Keloids can be forced into remission with surgical excision and radiation, followed by adjuvant therapy. Ann Plast Surg 67:402–406PubMedCrossRef Yamawaki S, Naitoh M, Ishiko T et al (2011) Keloids can be forced into remission with surgical excision and radiation, followed by adjuvant therapy. Ann Plast Surg 67:402–406PubMedCrossRef
31.
go back to reference Stahl S, Barnea Y, Weiss J et al (2010) Treatment of earlobe keloids by extralesional excision combined with preoperative and postoperative “sandwich” radiotherapy. Plast Reconstr Surg 125:135–141PubMedCrossRef Stahl S, Barnea Y, Weiss J et al (2010) Treatment of earlobe keloids by extralesional excision combined with preoperative and postoperative “sandwich” radiotherapy. Plast Reconstr Surg 125:135–141PubMedCrossRef
32.
go back to reference Sakamoto T, Oya N, Shibuya K et al (2009) Dose-response relationship and dose optimization in radiotherapy of postoperative keloids. Radiother Oncol 91:271–276PubMedCrossRef Sakamoto T, Oya N, Shibuya K et al (2009) Dose-response relationship and dose optimization in radiotherapy of postoperative keloids. Radiother Oncol 91:271–276PubMedCrossRef
33.
go back to reference Speranza G, Sultanem K, Muanza T (2008) Descriptive study of patients receiving excision and radiotherapy for keloids. Int J Radiat Oncol Biol Phys 71:1465–1469PubMedCrossRef Speranza G, Sultanem K, Muanza T (2008) Descriptive study of patients receiving excision and radiotherapy for keloids. Int J Radiat Oncol Biol Phys 71:1465–1469PubMedCrossRef
34.
go back to reference Ogawa R, Miyashita T, Hyakusoku H et al (2007) Postoperative radiation protocol for keloids and hypertrophic scars: statistical analysis of 370 sites followed for over 18 months. Ann Plast Surg 59:688–691PubMedCrossRef Ogawa R, Miyashita T, Hyakusoku H et al (2007) Postoperative radiation protocol for keloids and hypertrophic scars: statistical analysis of 370 sites followed for over 18 months. Ann Plast Surg 59:688–691PubMedCrossRef
35.
go back to reference Bischof M, Krempien R, Debus J, Treiber M (2007) Postoperative electron beam radiotherapy for keloids: objective findings and patient satisfaction in self-assessment. Int J Dermatol 46:971–975PubMedCrossRef Bischof M, Krempien R, Debus J, Treiber M (2007) Postoperative electron beam radiotherapy for keloids: objective findings and patient satisfaction in self-assessment. Int J Dermatol 46:971–975PubMedCrossRef
36.
go back to reference Malaker K, Vijayraghavan K, Hodson I, Al YT (2004) Retrospective analysis of treatment of unresectable keloids with primary radiation over 25 years. Clin Oncol (R Coll Radiol) 16:290–298CrossRef Malaker K, Vijayraghavan K, Hodson I, Al YT (2004) Retrospective analysis of treatment of unresectable keloids with primary radiation over 25 years. Clin Oncol (R Coll Radiol) 16:290–298CrossRef
37.
go back to reference Malaker K, Zaidi M, Franka MR (2004) Treatment of earlobe keloids using the cobalt 60 teletherapy unit. Ann Plast Surg 52:602–604PubMedCrossRef Malaker K, Zaidi M, Franka MR (2004) Treatment of earlobe keloids using the cobalt 60 teletherapy unit. Ann Plast Surg 52:602–604PubMedCrossRef
38.
go back to reference Maarouf M, Schleicher U, Schmachtenberg A, Ammon J (2002) Radiotherapy in the management of keloids. Clinical experience with electron beam irradiation and comparison with X-ray therapy. Strahlenther Onkol 178:330–335PubMedCrossRef Maarouf M, Schleicher U, Schmachtenberg A, Ammon J (2002) Radiotherapy in the management of keloids. Clinical experience with electron beam irradiation and comparison with X-ray therapy. Strahlenther Onkol 178:330–335PubMedCrossRef
39.
go back to reference Sclafani AP, Gordon L, Chadha M, Romo T 3rd (1996) Prevention of earlobe keloid recurrence with postoperative corticosteroid injections versus radiation therapy: a randomized, prospective study and review of the literature. Dermatol Surg 22:569–574PubMedCrossRef Sclafani AP, Gordon L, Chadha M, Romo T 3rd (1996) Prevention of earlobe keloid recurrence with postoperative corticosteroid injections versus radiation therapy: a randomized, prospective study and review of the literature. Dermatol Surg 22:569–574PubMedCrossRef
40.
go back to reference Klumpar DI, Murray JC, Anscher M (1994) Keloids treated with excision followed by radiation therapy. J Am Acad Dermatol 31:225–231PubMedCrossRef Klumpar DI, Murray JC, Anscher M (1994) Keloids treated with excision followed by radiation therapy. J Am Acad Dermatol 31:225–231PubMedCrossRef
41.
go back to reference Lo TC, Seckel BR, Salzman FA, Wright KA (1990) Single-dose electron beam irradiation in treatment and prevention of keloids and hypertrophic scars. Radiother Oncol 19:267–272PubMedCrossRef Lo TC, Seckel BR, Salzman FA, Wright KA (1990) Single-dose electron beam irradiation in treatment and prevention of keloids and hypertrophic scars. Radiother Oncol 19:267–272PubMedCrossRef
42.
go back to reference Sallstrom KO, Larson O, Heden P et al (1989) Treatment of keloids with surgical excision and postoperative X-ray radiation. Scand J Plast Reconstr Surg Hand Surg 23:211–215PubMed Sallstrom KO, Larson O, Heden P et al (1989) Treatment of keloids with surgical excision and postoperative X-ray radiation. Scand J Plast Reconstr Surg Hand Surg 23:211–215PubMed
43.
go back to reference Kovalic JJ, Perez CA (1989) Radiation therapy following keloidectomy: a 20-year experience. Int J Radiat Oncol Biol Phys 17:77–80PubMedCrossRef Kovalic JJ, Perez CA (1989) Radiation therapy following keloidectomy: a 20-year experience. Int J Radiat Oncol Biol Phys 17:77–80PubMedCrossRef
44.
go back to reference Borok TL, Bray M, Sinclair I et al (1988) Role of ionizing irradiation for 393 keloids. Int J Radiat Oncol Biol Phys 15:865–870PubMedCrossRef Borok TL, Bray M, Sinclair I et al (1988) Role of ionizing irradiation for 393 keloids. Int J Radiat Oncol Biol Phys 15:865–870PubMedCrossRef
45.
go back to reference Enhamre A, Hammar H (1983) Treatment of keloids with excision and postoperative X-ray irradiation. Dermatologica 167:90–93PubMedCrossRef Enhamre A, Hammar H (1983) Treatment of keloids with excision and postoperative X-ray irradiation. Dermatologica 167:90–93PubMedCrossRef
46.
go back to reference Anderson EM, David J, Phillips T et al (2021) Interstitial high-dose-rate brachytherapy in the treatment of keloids: moving toward a volumetric approach. Brachytherapy 20:185–188PubMedCrossRef Anderson EM, David J, Phillips T et al (2021) Interstitial high-dose-rate brachytherapy in the treatment of keloids: moving toward a volumetric approach. Brachytherapy 20:185–188PubMedCrossRef
47.
go back to reference Bijlard E, Verduijn GM, Harmeling JX et al (2018) Optimal high-dose-rate brachytherapy fractionation scheme after keloid excision: a retrospective multicenter comparison of recurrence rates and complications. Int J Radiat Oncol Biol Phys 100:679–686PubMedCrossRef Bijlard E, Verduijn GM, Harmeling JX et al (2018) Optimal high-dose-rate brachytherapy fractionation scheme after keloid excision: a retrospective multicenter comparison of recurrence rates and complications. Int J Radiat Oncol Biol Phys 100:679–686PubMedCrossRef
48.
go back to reference Jiang P, Geenen M, Siebert FA et al (2018) Efficacy and the toxicity of the interstitial high-dose-rate brachytherapy in the management of recurrent keloids: 5-year outcomes. Brachytherapy 17:597–600PubMedCrossRef Jiang P, Geenen M, Siebert FA et al (2018) Efficacy and the toxicity of the interstitial high-dose-rate brachytherapy in the management of recurrent keloids: 5-year outcomes. Brachytherapy 17:597–600PubMedCrossRef
49.
go back to reference Jiang P, Baumann R, Dunst J et al (2016) Perioperative interstitial high-dose-rate brachytherapy for the treatment of recurrent keloids: feasibility and early results. Int J Radiat Oncol Biol Phys 94:532–536PubMedCrossRef Jiang P, Baumann R, Dunst J et al (2016) Perioperative interstitial high-dose-rate brachytherapy for the treatment of recurrent keloids: feasibility and early results. Int J Radiat Oncol Biol Phys 94:532–536PubMedCrossRef
50.
go back to reference van Leeuwen MC, Stokmans SC, Bulstra AE et al (2015) Surgical excision with adjuvant irradiation for treatment of keloid scars: a systematic review. Plast Reconstr Surg Glob Open 3:e440PubMedPubMedCentralCrossRef van Leeuwen MC, Stokmans SC, Bulstra AE et al (2015) Surgical excision with adjuvant irradiation for treatment of keloid scars: a systematic review. Plast Reconstr Surg Glob Open 3:e440PubMedPubMedCentralCrossRef
51.
go back to reference De Cicco L, Vischioni B, Vavassori A et al (2014) Postoperative management of keloids: low-dose-rate and high-dose-rate brachytherapy. Brachytherapy 13:508–513PubMedCrossRef De Cicco L, Vischioni B, Vavassori A et al (2014) Postoperative management of keloids: low-dose-rate and high-dose-rate brachytherapy. Brachytherapy 13:508–513PubMedCrossRef
52.
go back to reference Kuribayashi S, Miyashita T, Ozawa Y et al (2011) Post-keloidectomy irradiation using high-dose-rate superficial brachytherapy. J Radiat Res 52:365–368PubMedCrossRef Kuribayashi S, Miyashita T, Ozawa Y et al (2011) Post-keloidectomy irradiation using high-dose-rate superficial brachytherapy. J Radiat Res 52:365–368PubMedCrossRef
53.
go back to reference Viani GA, Stefano EJ, Afonso SL, De Fendi LI (2009) Postoperative strontium-90 brachytherapy in the prevention of keloids: results and prognostic factors. Int J Radiat Oncol Biol Phys 73:1510–1516PubMedCrossRef Viani GA, Stefano EJ, Afonso SL, De Fendi LI (2009) Postoperative strontium-90 brachytherapy in the prevention of keloids: results and prognostic factors. Int J Radiat Oncol Biol Phys 73:1510–1516PubMedCrossRef
54.
go back to reference Veen RE, Kal HB (2007) Postoperative high-dose-rate brachytherapy in the prevention of keloids. Int J Radiat Oncol Biol Phys 69:1205–1208PubMedCrossRef Veen RE, Kal HB (2007) Postoperative high-dose-rate brachytherapy in the prevention of keloids. Int J Radiat Oncol Biol Phys 69:1205–1208PubMedCrossRef
55.
go back to reference Garg MK, Weiss P, Sharma AK et al (2004) Adjuvant high dose rate brachytherapy (Ir-192) in the management of keloids which have recurred after surgical excision and external radiation. Radiother Oncol 73:233–236PubMedCrossRef Garg MK, Weiss P, Sharma AK et al (2004) Adjuvant high dose rate brachytherapy (Ir-192) in the management of keloids which have recurred after surgical excision and external radiation. Radiother Oncol 73:233–236PubMedCrossRef
56.
go back to reference Guix B, Henriquez I, Andres A et al (2001) Treatment of keloids by high-dose-rate brachytherapy: a seven-year study. Int J Radiat Oncol Biol Phys 50:167–172PubMedCrossRef Guix B, Henriquez I, Andres A et al (2001) Treatment of keloids by high-dose-rate brachytherapy: a seven-year study. Int J Radiat Oncol Biol Phys 50:167–172PubMedCrossRef
57.
go back to reference Escarmant P, Zimmermann S, Amar A et al (1993) The treatment of 783 keloid scars by iridium 192 interstitial irradiation after surgical excision. Int J Radiat Oncol Biol Phys 26:245–251PubMedCrossRef Escarmant P, Zimmermann S, Amar A et al (1993) The treatment of 783 keloid scars by iridium 192 interstitial irradiation after surgical excision. Int J Radiat Oncol Biol Phys 26:245–251PubMedCrossRef
58.
go back to reference Ogawa R, Akita S, Akaishi S et al (2019) Diagnosis and treatment of keloids and hypertrophic scars-Japan scar workshop consensus document 2018. Burns Trauma 7:39PubMedPubMedCentralCrossRef Ogawa R, Akita S, Akaishi S et al (2019) Diagnosis and treatment of keloids and hypertrophic scars-Japan scar workshop consensus document 2018. Burns Trauma 7:39PubMedPubMedCentralCrossRef
59.
go back to reference Zhu Z, Shan Y, Ying L et al (2015) Complete earlobe keloid resection with fistulectomy. Dermatol Surg 41:83–86PubMedCrossRef Zhu Z, Shan Y, Ying L et al (2015) Complete earlobe keloid resection with fistulectomy. Dermatol Surg 41:83–86PubMedCrossRef
60.
go back to reference Ogawa R, Akaishi S, Dohi T et al (2015) Analysis of the surgical treatments of 63 keloids on the cartilaginous part of the auricle: effectiveness of the core excision method. Plast Reconstr Surg 135:868–875PubMedCrossRef Ogawa R, Akaishi S, Dohi T et al (2015) Analysis of the surgical treatments of 63 keloids on the cartilaginous part of the auricle: effectiveness of the core excision method. Plast Reconstr Surg 135:868–875PubMedCrossRef
61.
go back to reference Chong Y, Kim CW, Kim YS et al (2018) Complete excision of proliferating core in auricular keloids significantly reduces local recurrence: a prospective study. J Dermatol 45:139–144PubMedCrossRef Chong Y, Kim CW, Kim YS et al (2018) Complete excision of proliferating core in auricular keloids significantly reduces local recurrence: a prospective study. J Dermatol 45:139–144PubMedCrossRef
62.
go back to reference Sunohara M, Ozawa T, Harada T et al (2012) A technique for auricular keloid core excision using a skin biopsy punch. Aesthetic Plast Surg 36:628–630PubMedCrossRef Sunohara M, Ozawa T, Harada T et al (2012) A technique for auricular keloid core excision using a skin biopsy punch. Aesthetic Plast Surg 36:628–630PubMedCrossRef
63.
go back to reference Janis JE, Kwon RK, Lalonde DH (2010) A practical guide to wound healing. Plast Reconstr Surg 125:230e–244ePubMedCrossRef Janis JE, Kwon RK, Lalonde DH (2010) A practical guide to wound healing. Plast Reconstr Surg 125:230e–244ePubMedCrossRef
64.
go back to reference Ruiz-Tovar J, Alonso N, Morales V, Llavero C (2015) Association between triclosan-coated sutures for abdominal wall closure and incisional surgical site infection after open surgery in patients presenting with fecal peritonitis: a randomized clinical trial. Surg Infect (Larchmt) 16:588–594CrossRef Ruiz-Tovar J, Alonso N, Morales V, Llavero C (2015) Association between triclosan-coated sutures for abdominal wall closure and incisional surgical site infection after open surgery in patients presenting with fecal peritonitis: a randomized clinical trial. Surg Infect (Larchmt) 16:588–594CrossRef
65.
go back to reference Hayashi T, Furukawa H, Oyama A et al (2012) A new uniform protocol of combined corticosteroid injections and ointment application reduces recurrence rates after surgical keloid/hypertrophic scar excision. Dermatol Surg 38:893–897PubMedCrossRef Hayashi T, Furukawa H, Oyama A et al (2012) A new uniform protocol of combined corticosteroid injections and ointment application reduces recurrence rates after surgical keloid/hypertrophic scar excision. Dermatol Surg 38:893–897PubMedCrossRef
66.
go back to reference Boahene K, Brissett AE, Jones LR (2018) Facial plastic surgery controversies: keloids. Facial Plast Surg Clin North Am 26:105–112PubMedCrossRef Boahene K, Brissett AE, Jones LR (2018) Facial plastic surgery controversies: keloids. Facial Plast Surg Clin North Am 26:105–112PubMedCrossRef
67.
go back to reference Donkor P (2007) Head and neck keloid: treatment by core excision and delayed intralesional injection of steroid. J Oral Maxillofac Surg 65:1292–1296PubMedCrossRef Donkor P (2007) Head and neck keloid: treatment by core excision and delayed intralesional injection of steroid. J Oral Maxillofac Surg 65:1292–1296PubMedCrossRef
68.
go back to reference Choi YJ, Lee YH, Lee HJ et al (2020) Auricular keloid management in Asian skin: clinical outcome of intralesional excision and postoperative triamcinolone acetonide intralesional injection. J Cosmet Dermatol 19:3041–3047PubMedCrossRef Choi YJ, Lee YH, Lee HJ et al (2020) Auricular keloid management in Asian skin: clinical outcome of intralesional excision and postoperative triamcinolone acetonide intralesional injection. J Cosmet Dermatol 19:3041–3047PubMedCrossRef
69.
go back to reference De Bearman R GH. Cheloides des maqueuses. Ann Dermatol Syphilol (Paris) 1906; 7: 151 De Bearman R GH. Cheloides des maqueuses. Ann Dermatol Syphilol (Paris) 1906; 7: 151
70.
go back to reference Cosman BCG, Ju DM, Gaulin JC, Lattes R (1961) The surgical treatment of keloids. Plas Reconstr Surg 27:335–358CrossRef Cosman BCG, Ju DM, Gaulin JC, Lattes R (1961) The surgical treatment of keloids. Plas Reconstr Surg 27:335–358CrossRef
71.
go back to reference Ollstein RN, Siegel HW, Gillooley JF, Barsa JM (1981) Treatment of keloids by combined surgical excision and immediate postoperative X-ray therapy. Ann Plast Surg 7:281–285PubMedCrossRef Ollstein RN, Siegel HW, Gillooley JF, Barsa JM (1981) Treatment of keloids by combined surgical excision and immediate postoperative X-ray therapy. Ann Plast Surg 7:281–285PubMedCrossRef
72.
go back to reference Berman B, Maderal A, Raphael B (2017) Keloids and hypertrophic scars: pathophysiology, classification, and treatment. Dermatol Surg 43(Suppl 1):S3–S18PubMedCrossRef Berman B, Maderal A, Raphael B (2017) Keloids and hypertrophic scars: pathophysiology, classification, and treatment. Dermatol Surg 43(Suppl 1):S3–S18PubMedCrossRef
73.
go back to reference Nicoletis C (1967) Chassagne D [interstitial irradiation by iridium 192 in the prevention of recurrence after surgical excision of keloid cicatrices]. Ann Chir Plast 12:237–242PubMed Nicoletis C (1967) Chassagne D [interstitial irradiation by iridium 192 in the prevention of recurrence after surgical excision of keloid cicatrices]. Ann Chir Plast 12:237–242PubMed
74.
go back to reference Arneja JS, Singh GB, Dolynchuk KN et al (2008) Treatment of recurrent earlobe keloids with surgery and high-dose-rate brachytherapy. Plast Reconstr Surg 121:95–99PubMedCrossRef Arneja JS, Singh GB, Dolynchuk KN et al (2008) Treatment of recurrent earlobe keloids with surgery and high-dose-rate brachytherapy. Plast Reconstr Surg 121:95–99PubMedCrossRef
75.
go back to reference Wagner W, Alfrink M, Micke O et al (2000) Results of prophylactic irradiation in patients with resected keloids–a retrospective analysis. Acta Oncol 39:217–220PubMedCrossRef Wagner W, Alfrink M, Micke O et al (2000) Results of prophylactic irradiation in patients with resected keloids–a retrospective analysis. Acta Oncol 39:217–220PubMedCrossRef
76.
go back to reference Seegenschmiedt MH, Micke O, Willich N (2004) Radiation therapy for nonmalignant diseases in Germany. Current concepts and future perspectives. Strahlenther Onkol 180:718–730PubMedCrossRef Seegenschmiedt MH, Micke O, Willich N (2004) Radiation therapy for nonmalignant diseases in Germany. Current concepts and future perspectives. Strahlenther Onkol 180:718–730PubMedCrossRef
77.
go back to reference Gurtner GC, Werner S, Barrandon Y, Longaker MT (2008) Wound repair and regeneration. Nature 453:314–321PubMedCrossRef Gurtner GC, Werner S, Barrandon Y, Longaker MT (2008) Wound repair and regeneration. Nature 453:314–321PubMedCrossRef
78.
go back to reference Kal HB, Veen RE (2005) Biologically effective doses of postoperative radiotherapy in the prevention of keloids dose-effect relationship. Strahlenther Onkol 181:717–723PubMedCrossRef Kal HB, Veen RE (2005) Biologically effective doses of postoperative radiotherapy in the prevention of keloids dose-effect relationship. Strahlenther Onkol 181:717–723PubMedCrossRef
79.
go back to reference Barendsen GW (1982) Dose fractionation, dose rate and iso-effect relationships for normal tissue responses. Int J Radiat Oncol Biol Phys 8:1981–1997PubMedCrossRef Barendsen GW (1982) Dose fractionation, dose rate and iso-effect relationships for normal tissue responses. Int J Radiat Oncol Biol Phys 8:1981–1997PubMedCrossRef
80.
go back to reference Thames HD Jr, Withers HR, Peters LJ, Fletcher GH (1982) Changes in early and late radiation responses with altered dose fractionation: implications for dose-survival relationships. Int J Radiat Oncol Biol Phys 8:219–226PubMedCrossRef Thames HD Jr, Withers HR, Peters LJ, Fletcher GH (1982) Changes in early and late radiation responses with altered dose fractionation: implications for dose-survival relationships. Int J Radiat Oncol Biol Phys 8:219–226PubMedCrossRef
81.
go back to reference Wang QG, Li XM, Zhang M et al (2014) [Effect of two dose fractionations on postoperative radiotherapy of keloid: an analysis of 107 patients]. Beijing Da Xue Xue Bao Yi Xue Ban 46:169–172PubMed Wang QG, Li XM, Zhang M et al (2014) [Effect of two dose fractionations on postoperative radiotherapy of keloid: an analysis of 107 patients]. Beijing Da Xue Xue Bao Yi Xue Ban 46:169–172PubMed
82.
go back to reference Malaker A, Ellis F, Paine CH (1976) Keloid scars: a new method of treatment combining surgery with interstitial radiotherapy. Clin Radiol 27:179–183PubMedCrossRef Malaker A, Ellis F, Paine CH (1976) Keloid scars: a new method of treatment combining surgery with interstitial radiotherapy. Clin Radiol 27:179–183PubMedCrossRef
83.
go back to reference Ogawa R, Huang C, Akaishi S et al (2013) Analysis of surgical treatments for earlobe keloids: analysis of 174 lesions in 145 patients. Plast Reconstr Surg 132:818e–825ePubMedCrossRef Ogawa R, Huang C, Akaishi S et al (2013) Analysis of surgical treatments for earlobe keloids: analysis of 174 lesions in 145 patients. Plast Reconstr Surg 132:818e–825ePubMedCrossRef
84.
go back to reference Ragoowansi R, Cornes PG, Moss AL, Glees JP (2003) Treatment of keloids by surgical excision and immediate postoperative single-fraction radiotherapy. Plast Reconstr Surg 111:1853–1859PubMedCrossRef Ragoowansi R, Cornes PG, Moss AL, Glees JP (2003) Treatment of keloids by surgical excision and immediate postoperative single-fraction radiotherapy. Plast Reconstr Surg 111:1853–1859PubMedCrossRef
85.
go back to reference Fraunholz IB, Gerstenhauer A, Bottcher HD (2005) Results of postoperative (90)Sr radiotherapy of keloids in view of patients’ subjective assessment. Strahlenther Onkol 181:724–729PubMedCrossRef Fraunholz IB, Gerstenhauer A, Bottcher HD (2005) Results of postoperative (90)Sr radiotherapy of keloids in view of patients’ subjective assessment. Strahlenther Onkol 181:724–729PubMedCrossRef
86.
go back to reference Ogawa R, Yoshitatsu S, Yoshida K, Miyashita T (2009) Is radiation therapy for keloids acceptable? The risk of radiation-induced carcinogenesis. Plast Reconstr Surg 124:1196–1201PubMedCrossRef Ogawa R, Yoshitatsu S, Yoshida K, Miyashita T (2009) Is radiation therapy for keloids acceptable? The risk of radiation-induced carcinogenesis. Plast Reconstr Surg 124:1196–1201PubMedCrossRef
87.
go back to reference Biemans RG (1963) A rare case of sarcomatous degeneration of a cheloid. Arch Chir Neerl 15:175–185PubMed Biemans RG (1963) A rare case of sarcomatous degeneration of a cheloid. Arch Chir Neerl 15:175–185PubMed
88.
go back to reference Leer JW, van Houtte P, Davelaar J (1998) Indications and treatment schedules for irradiation of benign diseases: a survey. Radiother Oncol 48:249–257PubMedCrossRef Leer JW, van Houtte P, Davelaar J (1998) Indications and treatment schedules for irradiation of benign diseases: a survey. Radiother Oncol 48:249–257PubMedCrossRef
Metadata
Title
Adjuvant Radiotherapy for Keloids
Authors
Wenfang Dong
Bin Qiu
Fei Fan
Publication date
01-02-2022
Publisher
Springer US
Published in
Aesthetic Plastic Surgery / Issue 1/2022
Print ISSN: 0364-216X
Electronic ISSN: 1432-5241
DOI
https://doi.org/10.1007/s00266-021-02442-w

Other articles of this Issue 1/2022

Aesthetic Plastic Surgery 1/2022 Go to the issue