Published in:
11-08-2023 | Bone Metastasis | Computed Tomography
Spectral CT assists differentiation of osteoblastic bone metastasis from bone island in newly diagnosed cancer patients
Published in: European Radiology | Issue 1/2024
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Objectives
To investigate measurements derived from plain and enhanced spectral CT in differentiating osteoblastic bone metastasis (OBM) from bone island (BI).
Materials and methods
From January to November 2020, 73 newly diagnosed cancer patients with 201 bone lesions (OBM = 92, BI = 109) having received spectral CT were retrospectively enrolled. Measurements including CT values of 40–140 keV, slope of the spectral curve, effective atomic number (Zeff), water (calcium) density, calcium (water) density, and Iodine (calcium) density were derived from manually segmented lesions on plain and enhanced spectral CT, and then analyzed using Student t-test and Pearson’s correlation. Multivariate analysis was performed to build models (plain spectral model, enhanced spectral CT model, and combined model) for the discrimination of OBM and BI with performance evaluated using receiver operator characteristics curve and DeLong test.
Results
All features were significantly different between the BI group and OBM group (all p < 0.05), highly correlated with the corresponding features between plain and enhanced spectral CT both in OBM (r: 0.392–0.763) and BI (r: 0.430–0.544). As for the model performance, the combined model achieved the best performance (AUC = 0.925, 95% CI: 0.879 to 0.957), which significantly outperformed the plain spectral CT model (AUC = 0.815, 95% CI: 0.754 to 0.866, p < 0.001) and enhanced spectral CT model (AUC = 0.901, 95% CI: 0.852 to 0.939, p = 0.024) in differentiating OBM and BI.
Conclusion
In addition to plain spectral CT measurements, enhanced spectral CT measurements would further significantly benefit the differential diagnosis.
Clinical relevance statement
Measurements derived either from plain or enhanced spectral CT could provide additional valuable information to improve the differential diagnosis between OBM and BI in newly diagnosed cancer patients.
Key Points
• We intend to investigate plain and enhanced spectral CT measurements in differentiating OBM from BI.
• Both plain and enhanced spectral CT help in discriminating OBM and BI in newly diagnosed cancer patients.
• Enhanced spectral CT measurements further improve plain spectral CT measurements-based differential diagnosis.