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Current Osteoporosis Reports

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01-06-2021 | Bone Metastasis | Cancer-induced Musculoskeletal Diseases (C Lynch and J Sterling, Section Editors)

Extracellular Vesicles and Bone-Associated Cancer

Authors: Jinlu Dai, Alison B. Shupp, Karen M. Bussard, Evan T. Keller

Published in: Current Osteoporosis Reports | Issue 3/2021

Abstract

Purpose of Review

In this review, we describe the biology of extracellular vesicles (EV) and how they contribute to bone-associated cancers.

Recent Findings

Crosstalk between tumor and bone has been demonstrated to promote tumor and metastatic progression. In addition to direct cell-to-cell contact and soluble factors, such as cytokines, EVs mediate crosstalk between tumor and bone. EVs are composed of a heterogenous group of membrane-delineated vesicles of varying size range, mechanisms of formation, and content. These include apoptotic bodies, microvesicles, large oncosomes, and exosomes. EVs derived from primary tumors have been shown to alter bone remodeling and create formation of a pre-metastatic niche that favors development of bone metastasis. Similarly, EVs from marrow stromal cells have been shown to promote tumor progression. Additionally, EVs can act as therapeutic delivery vehicles due to their low immunogenicity and targeting specificity.

Summary

EVs play critical roles in intercellular communication. Multiple classes of EVs exist based on size on mechanism of formation. In addition to a role in pathophysiology, EVs can be exploited as therapeutic delivery vehicles.

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Title: Extracellular Vesicles and Bone-Associated Cancer
Authors: Jinlu Dai
Alison B. Shupp
Karen M. Bussard
Evan T. Keller
Publication date: 01-06-2021
Publisher: Springer US
Keyword: Bone Metastasis
Published in: Current Osteoporosis Reports / Issue 3/2021
Print ISSN: 1544-1873
Electronic ISSN: 1544-2241
DOI: https://doi.org/10.1007/s11914-021-00668-w

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Extracellular Vesicles and Bone-Associated Cancer

Abstract

Purpose of Review

Recent Findings

Summary

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Purpose of Review

Recent Findings

Summary

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