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01-09-2005 | Original Article

Bone measurements of infants in the first 3 months of life by quantitative ultrasound: the influence of gestational age, season, and postnatal age

Authors: Xiang-peng Liao, Wei-li Zhang, Jiamin He, Jian-hua Sun, Ping Huang

Published in: Pediatric Radiology | Issue 9/2005

Abstract

Background: There are a few quantitative ultrasound (QUS) studies of bone status for Chinese children. Objective: To evaluate the clinical application and to investigate the bone status of neonates and young infants with QUS. Materials and methods: An ultrasound bone sonometer was used to measure the bone speed of sound (SOS) of the tibia in 542 neonates within 3 months of birth. Results: At birth, no significant difference of SOS was found between boys and girls, but there was a significant difference of SOS between premature infants and full-term infants. The SOS in neonates born during spring and summer was significantly lower than those born during autumn and winter. There were significant correlations between SOS and gestational age, and between bone SOS and birth weight in appropriate for gestational age (AGA) infants. Multiple regression analysis found that gestational age and infant birth season were two important factors influencing SOS. During the first 3 months, there was no significant difference in SOS between sexes. The SOS of infants showed an inverse correlation with postnatal age, and the decrease of bone SOS with age in premature infants was more marked than in full-term infants. Conclusions: QUS is suitable for evaluating bone status in infants with high precision. The study offers some basic data for neonates and young infants.

Steelman J, Zeitler P (2001) Osteoporosis in pediatrics. Pediatr Rev 22:56–65PubMed

Gertner JM (1990) Disorders of calcium and phosphorus homeostasis. Pediatr Clin North Am 37:1441–1465PubMed

Wunsche K, Wunsche B, Fahnrich H, et al (2000) Ultrasound bone densitometry of the os calcis in children and adolescents. Calcif Tissue Int 67:349–355CrossRefPubMed

Fogelman I, Blake GM (2000) Different approaches to bone densitometry. J Nucl Med 41:2015–2025PubMed

Gilsanz V (1998) Bone density in children: a review of the available techniques and indications. Eur J Radiol 26:177–182CrossRefPubMed

Rauch F, Schoenau E (2002) Skeletal development in premature infants: a review of bone physiology beyond nutritional aspects. Arch Dis Child Fetal Neonatal Ed 86:F82–F85CrossRefPubMed

Prins SH, Jorgensen HL, Jorgensen LV, et al (1998) The role of quantitative ultrasound in the assessment of bone: a review. Clin Physiol 18:3–17CrossRefPubMed

Mehta SS, Antich PP, Daphtary MM, et al (2001) Bone material ultrasound velocity is predictive of whole bone strength. Ultrasound Med Biol 27:861–867CrossRefPubMed

Zadik Z, Price D, Diamond G (2003) Pediatric reference curves for multi-site quantitative ultrasound and its modulators. Osteoporos Int 14:857–862CrossRefPubMed

10.

Wright LL, Glade MJ, Gopal J (1987) The use of transmission ultrasonics to assess bone status in the human newborn. Pediatr Res 22:541–544PubMed

11.

Nemet D, Dolfin T, Wolach B, et al (2001) Quantitative ultrasound measurements of bone speed of sound in premature infants. Eur J Pediatr 160:736–740PubMed

12.

Eliakim A, Nemet D, Friedland O, et al (2002) Spontaneous activity in premature infants affects bone strength. J Perinatol 22:650–652CrossRefPubMed

13.

Litmanovitz I, Dolfin T, Friedland O, et al (2003) Early physical activity intervention prevents decrease of bone strength in very low birth weight infants. Pediatrics 112:15–19CrossRefPubMed

14.

Rubinacci A, Moro GE, Boehm G, et al (2003) Quantitative ultrasound for the assessment of osteopenia in preterm infants. Eur J Endocrinol 149:307–315CrossRefPubMed

15.

Pereda L, Ashmeade T, Zaritt J, et al (2003) The use of quantitative ultrasound in assessing bone status in newborn preterm infants. J Perinatol 23:655–659CrossRefPubMed

16.

Rubinacci A, Moro GE, Boehm G, et al (2003) Quantitative ultrasound for the assessment of osteopenia in preterm infants. Eur J Endocrinol 149:307–315CrossRefPubMed

17.

Javiaid MK, Cooper C (2002) Prenatal and childhood influences on osteoporosis. Best Pract Res Clin Endocrinol Metab 16:349–367CrossRefPubMed

18.

Yan L, Crabtree NJ, Reeve J, et al (2004) Does hip strength analysis explain the lower incidence of hip fracture in the People’s Republic of China? Bone 34:584–588CrossRefPubMed

19.

Zhang ZL, Zhao JX, Meng XW, et al (2003) Association of polymorphisms of vitamin D receptor gene start codon and 3’-end region with bone mineral density in postmenopausal women. Zhanghua Yi Xue Yi Chuan Xue Za Zhi 20:5–8

20.

Lequin MH, van Rijn RR, Robben SG, et al (1999) Evaluation of short-term precision for tibial ultrasonometry. Calcif Tissue Int 64:24–27CrossRefPubMed

21.

van den Bergh JP, Noordam C, Thijssen JM, et al (2001) Measuring skeletal changes with calcaneal ultrasound imaging in healthy children and adults: the influence of size and location of the region of interest. Osteoporos Int 12:970–979CrossRefPubMed

22.

Knapp KM, Blake GM, Spector TD, et al (2001) Multisite quantitative ultrasound: precision, age- and menopause-related changes, fracture discrimination, and T-score equivalence with dual-energy X-ray absorptiometry. Osteoporos Int 12:456–464CrossRefPubMed

23.

Sosa M, Saavedra P, Munoz-Torres M, et al (2002) Quantitative ultrasound calcaneus measurements: normative data and precision in the Spanish population. Osteoporos Int 13:487–492CrossRefPubMed

24.

Hori C, Tsukahara H, Fujii Y, et al (1995) Bone mineral status in preterm-born children: assessment by dual-energy X-ray absorptiometry. Biol Neonate 68:254–258PubMed

25.

Fewtrell MS, Prentice A, Jones SC, et al (1999) Bone mineralization and turnover in preterm infants at 8–12 years of age: the effect of early diet. J Bone Miner Res 14:810–820PubMed

26.

Zamora SA, Belli DC, Rizzoli R, et al (2001) Lower femoral neck bone mineral density in prepubertal former preterm girls. Bone 29:424–427CrossRefPubMed

27.

Fewtrell MS, Cole TJ, Bishop NJ, et al (2000) Neonatal factors predicting childhood height in preterm infants: evidence for a persisting effect of early metabolic bone disease? J Pediatr 137:668–673CrossRefPubMed

28.

Njeh CF, Hans D, Wu C, et al (1999) An in vitro investigation of the dependence on sample thickness of the speed of sound along the specimen. Med Eng Phys 21:651–659CrossRefPubMed

29.

Bouxsein ML, Radloff SE (1997) Quantitative ultrasound of the calcaneus reflects the mechanical properties of calcaneal trabecular bone. J Bone Miner Res 12:839–846PubMed

30.

Usher R, McLean F (1969) Intrauterine growth of live-born Caucasian infants at sea level: standards obtained from measurements in 7 dimensions of infants born between 25 and 44 weeks of gestation. J Pediatr 74:901–910PubMed

31.

Namgung R, Mimouni F, Campaigne BN, et al (1992) Low bone mineral content in summer-born compared with winter-born infants. J Pediatr Gastroenterol Nutr 15:285–288PubMed

32.

Namgung R, Tsang RC, Specker BL, et al (1994) Low bone mineral content and high serum osteocalcin and 1,25-dihydroxyvitamin D in summer versus winter-born newborn infants: an early fetal effect? J Pediatr Gastroenterol Nutr 19:220–227PubMed

33.

Namgung R, Tsang RC, Specker BL, et al (1993) Reduced serum osteo calcin and 1,2,5-dighydroxyvitamin D concentrations and low bone mineralinfants; evidence of decreased bone formation rates. J Pediatr 122:269–275PubMed

34.

Delmas PD, Eastell R, Garnero P, et al (2000) The use of biochemical markers of bone turnover in osteoporosis. Committee of Scientific Advisors of the International Osteoporosis Foundation. Osteoporos Int 11[Suppl 6]:S2–S17CrossRefPubMed

35.

Rapuri PB, Kinyamu HK, Gallagher JC, et al (2002) Seasonal changes in calciotropic hormones, bone markers, and bone mineral density in elderly women. J Clin Endocrinol Metab 87:2024–2032CrossRefPubMed

36.

Woitge HW, Knothe A, Witte K, et al (2000) Circaannual rhythms and interactions of vitamin D metabolites, parathyroid hormone, and biochemical markers of skeletal homeostasis: a prospective study. J Bone Miner Res 15:2443–2450PubMed

37.

Han VK, Carter AM (2001) Control of growth and development of the feto-placental unit. Curr Opin Pharmacol 1:632–640CrossRefPubMed

38.

Miller ME (2003) The bone disease of preterm birth: a biomechanical perspective. Pediatr Res 53:10–15CrossRefPubMed

39.

Rauch F, Schoenau E (2001) Changes in bone density during childhood and adolescence: an approach based on bone’s biological organization. J Bone Miner Res 16:597–604PubMed

40.

Ge KY, Chang SY (2001) Dietary intake of some essential micronutrients in China. Biomed Environ Sci 14:318–324PubMed

41.

Li JY, Specker BL, Ho ML, et al (1989) Bone mineral content in black and white children 1 to 6 years of age. Am J Dis Child 143:1346–1348PubMed

Title: Bone measurements of infants in the first 3 months of life by quantitative ultrasound: the influence of gestational age, season, and postnatal age
Authors: Xiang-peng Liao
Wei-li Zhang
Jiamin He
Jian-hua Sun
Ping Huang
Publication date: 01-09-2005
Publisher: Springer-Verlag
Published in: Pediatric Radiology / Issue 9/2005
Print ISSN: 0301-0449
Electronic ISSN: 1432-1998
DOI: https://doi.org/10.1007/s00247-005-1481-z

At a glance: The STEP trials

Springer Medicine

Bone measurements of infants in the first 3 months of life by quantitative ultrasound: the influence of gestational age, season, and postnatal age

Abstract

At a glance: The STEP trials

Springer Medicine

Abstract

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