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Reviews in Endocrine and Metabolic Disorders
Published in: Reviews in Endocrine and Metabolic Disorders 2/2015

01-06-2015

Bone kidney interactions

Authors: Thomas L. Nickolas, Sophie A. Jamal

Published in: Reviews in Endocrine and Metabolic Disorders | Issue 2/2015

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Abstract

The fact that bone disease and kidney disease co-exist is well known. Formally, this inter-relationship is called chronic kidney disease mineral bone disorder or CKD-MBD. Traditionally, it was thought that bone played a passive role in CKD-MBD - specifically that kidney disease caused disordered mineral metabolism which resulted in bone disease and ultimately fractures. More recently however our understanding of bone function in general and the role that bone plays in CKD-MBD in particular, has changed. This chapter will briefly review epidemiology of fractures in chronic kidney disease (CKD) and the roles that imaging and measuring markers of mineral metabolism can play in assessing fracture risk. We will then review more recent data consistent with the concept MBD occurs early in the course of CKD and, via the secretion of novel molecules and/or signalling pathways, the bone can influence other organ systems.
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Metadata
Title
Bone kidney interactions
Authors
Thomas L. Nickolas
Sophie A. Jamal
Publication date
01-06-2015
Publisher
Springer US
Published in
Reviews in Endocrine and Metabolic Disorders / Issue 2/2015
Print ISSN: 1389-9155
Electronic ISSN: 1573-2606
DOI
https://doi.org/10.1007/s11154-015-9314-3

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