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International Urogynecology Journal

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01-04-2021 | Original Article

Body mass index influences the risk of reoperation after first-time surgery for pelvic organ prolapse. A Danish cohort study, 2010–2016

Authors: Vibeke Weltz, Rikke Guldberg, Michael Due Larsen, Gunnar Lose

Published in: International Urogynecology Journal | Issue 4/2021

Abstract

Introduction and hypothesis

The aims of this study were to evaluate the impact of body mass index (BMI) on the risk of reoperation for pelvic organ prolapse (POP) up to 5 years after first-time surgery.

Materials and methods

This nationwide register-based study includes first-time POP surgery in 2010 through 2016. The cumulative incidence proportions of reoperation were analyzed in a Cox regression model and described using Kaplan-Meier plots stratified in BMI categories.

Results

A total of 28,533 first-time procedures were performed in 22,624 women; 76.6% had single-compartment repair. The 1- and 5-year reoperation rate within the same compartment was 2.6% and 6.1% respectively for women with BMI < 25, and for women with BMI > 35 it was 3.7% and 11.2 respectively. In the anterior compartment there was a significantly increased adjusted hazard ratio for reoperation in the same compartment with increasing BMI (reference group BMI < 25), BMI 30–34.9 with an aHR = 1.34 (CI 95% 1.04–1.71) and BMI ≥ 35 aHR = 1.77 (CI 95% 1.17–2.67). The 1- and 5-year reoperation rate in an adjacent compartment was 0.6% and 1.6% respectively for women with BMI < 25, and for women with BMI > 35 it was 1.0% and 4.4 respectively. For reoperation in an adjacent compartment the adjusted results were BMI 30–34.9 aHR = 1.64 (95% CI 1.05–2.56) and BMI > 35 aHR = 2.64 (95% CI 1.36–5.14) when the first-time operation was in the anterior compartment.

Conclusions

If the woman had BMI > 35 and first-time surgery was in the anterior compartment, she had an almost doubled risk of reoperation within 5 years both in the same compartment and in an adjacent compartment compared to women with BMI < 35. In the apical and posterior compartment there was a trend towards increasing risk of reoperation with increasing BMI, although with a broad confidence interval.

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Title: Body mass index influences the risk of reoperation after first-time surgery for pelvic organ prolapse. A Danish cohort study, 2010–2016
Authors: Vibeke Weltz
Rikke Guldberg
Michael Due Larsen
Gunnar Lose
Publication date: 01-04-2021
Publisher: Springer International Publishing
Published in: International Urogynecology Journal / Issue 4/2021
Print ISSN: 0937-3462
Electronic ISSN: 1433-3023
DOI: https://doi.org/10.1007/s00192-020-04482-3

At a glance: The STEP trials

Springer Medicine

Body mass index influences the risk of reoperation after first-time surgery for pelvic organ prolapse. A Danish cohort study, 2010–2016

Abstract

Introduction and hypothesis

Materials and methods

Results

Conclusions

At a glance: The STEP trials

Springer Medicine

Abstract

Introduction and hypothesis

Materials and methods

Results

Conclusions

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