Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress
Clinical Collections
Advances in Alzheimer’s

Keynote webinar | Spotlight on medication adherence

LIVE: Thursday 27th June 2024, 18:00-19:30 (CEST)
Join our expert panel to discover why you need to understand the drivers of non-adherence in your patients, and how you can optimize medication adherence in your clinics to drastically improve patient outcomes.
ADVANCED SEARCH
Log in
Top
BMC Public Health
Published in: BMC Public Health 1/2024

Open Access 01-12-2024 | Research

Bisphenol A and its alternatives bisphenol S and F exposure with serum uric acid levels, hyperuricemia, and gout prevalence among US adults: a nationally representative cross-sectional study

Authors: Shunli Jiang, Yongxin Wang, Zengliang Wang, Yaru Xu, Xi Li, Mingjia Sun, Bo Li

Published in: BMC Public Health | Issue 1/2024

Login to get access

Abstract

Background

Recent studies suggested inconclusive associations between bisphenols exposure and hyperuricemia risk. Our objective was to assess the potential association of bisphenol A (BPA) and its substitutes bisphenol S and F (BPS and BPF) exposure with serum uric acid (SUA) levels, hyperuricemia, and gout prevalence among US adults within the NHANES 2013-2016 datasets.

Methods

Multivariable linear and logistic regression models were used to explore the associations of urinary bisphenols concentrations with SUA levels, hyperuricemia, and gout prevalence, in total population and different sex groups. The restricted cubic spline (RCS) model was used to explore the dose-response relationship.

Results

In total population, doubling of urinary BPS and ∑BPs concentrations showed associations with an increase of 2.64 μmol/L (95% CI: 0.54, 4.74) and 3.29 μmol/L (95% CI: 0.59, 5.99) in SUA levels, respectively. The RCS model indicated a significantly “J”-shaped dose-response relationship between BPS exposure and SUA levels. Compared to the reference group of urinary BPS, males in the highest quartile displayed a 13.06 μmol/L (95% CI: 0.75, 25.37) rise in SUA levels. For females, doubling of urinary BPS concentrations was associated with a 3.30 μmol/L (95% CI: 0.53, 6.07) increase in SUA levels, with a significant linear dose-response relationship. In total population, doubling of urinary BPA concentrations showed a 1.05-fold (95% CI: 0.97, 1.14) adjusted risk of having hyperuricemia, with an inverted “U” curve. Doubling of urinary ∑BPs concentrations was associated with a 1.05-fold (95% CI: 0.96, 1.14) adjusted risk of hyperuricemia in total population, with a significant monotonic dose-response relationship. In females, doubling of urinary BPS concentrations was associated with a 1.45-fold (95% CI: 1.01, 2.08) adjusted increased risk of having gout, with a “J” shaped relationship.

Conclusions

BPA and BPS exposure to some extent were associated with elevated SUA levels and increased risk of hyperuricemia, with different dose-response relationships and sex differences.
Appendix
Available only for authorised users
Literature
1.
Rock KL, Kataoka H, Lai JJ. Uric acid as a danger signal in gout and its comorbidities. Nat Rev Rheumatol. 2013;9(1):13–23.CrossRefPubMed
2.
Kuo CF, Grainge MJ, Zhang W, Doherty M. Global epidemiology of gout: prevalence, incidence and risk factors. Nat Rev Rheumatol. 2015;11(11):649–62.CrossRefPubMed
3.
4.
Kim Y, Kang J, Kim G-T. Prevalence of hyperuricemia and its associated factors in the general Korean population: an analysis of a population-based nationally representative sample. Clin Rheumatol. 2018;37(9):2529–38.CrossRefPubMed
5.
6.
Chen-Xu M, Yokose C, Rai SK, Pillinger MH, Choi HK. Contemporary Prevalence of Gout and Hyperuricemia in the United States and Decadal Trends: The National Health and Nutrition Examination Survey, 2007–2016. Arthritis Rheumatol. 2019;71(6):991–9.CrossRefPubMedPubMedCentral
7.
Krishnan E, Lingala B, Bhalla V. Low-level lead exposure and the prevalence of gout: an observational study. Ann Intern Med. 2012;157(4):233–41.CrossRefPubMed
8.
Kuo CC, Weaver V, Fadrowski JJ, Lin YS, Guallar E, Navas-Acien A. Arsenic exposure, hyperuricemia, and gout in US adults. Environ Int. 2015;76:32–40.CrossRefPubMed
9.
Jiang S, Liu H, Zhou S, Zhang X, Peng C, Zhou H, Tong Y, Lu Q. Association of bisphenol A and its alternatives bisphenol S and F exposure with hypertension and blood pressure: a cross-sectional study in China. Environ Pollut. 2020;257:113639.CrossRefPubMed
10.
Almeida S, Raposo A, Almeida-González M, Carrascosa C. Bisphenol A: food exposure and impact on human health. Compr Rev Food Sci Food Saf. 2018;17(6):1503–17.CrossRefPubMed
11.
12.
Ye X, Wong L-Y, Kramer J, Zhou X, Jia T, Calafat AM. Urinary concentrations of bisphenol A and three other bisphenols in convenience samples of US adults during 2000–2014. Environ Sci Technol. 2015;49(19):11834–9.CrossRefPubMedPubMedCentralADS
13.
Chen D, Kannan K, Tan H, Zheng Z, Feng YL, Wu Y, Widelka M. Bisphenol Analogues Other Than BPA: Environmental Occurrence, Human Exposure, and Toxicity-A Review. Environ Sci Technol. 2016;50(11):5438–53.CrossRefPubMedADS
14.
Lee YJ, Lim YH, Shin CH, Kim BN, Kim JI, Hong YC, Cho YM, Lee YA. Relationship between bisphenol A, bisphenol S, and bisphenol F and serum uric acid concentrations among school-aged children. PLoS One. 2022;17(6):e0268503.CrossRefPubMedPubMedCentral
15.
Hu J, Peng C, Li J, Gao R, Zhang A, Ma L, Zhang L, Yang Y, Cheng Q, Wang Y, et al. Serum Bisphenol A is an independent risk factor of hyperuricemia: A 6-year prospective study. Semin Arthritis Rheum. 2019;48(4):644–8.CrossRefPubMed
16.
Aekplakorn W, Chailurkit LO, Ongphiphadhanakul B. Association of serum bisphenol a with hypertension in thai population. Int J Hypertens. 2015;2015:594189.CrossRefPubMedPubMedCentral
17.
Jiang S, Sun M, Zhou X, Xu Y, Ullah H, Niu X, Feng C, Gao Q. Association between blood manganese levels and depressive symptoms among US adults: a nationally representative cross-sectional study. J Affect Disord. 2023;333:65–71.CrossRefPubMed
18.
von Elm E, Altman DG, Egger M, Pocock SJ, Gøtzsche PC, Vandenbroucke JP, STROBE Initiative. The Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) statement: guidelines for reporting observational studies. Lancet (London, England). 2007;370(9596):1453–7. https://​doi.​org/​10.​1016/​S0140-6736(07)61602-X.
19.
20.
Chittoor G, Voruganti VS: Chapter 53 - Hyperuricemia and Gout. In: Principles of Nutrigenetics and Nutrigenomics. edn. Edited by Caterina RDE, Martinez JA, Kohlmeier M. London: Elsevier, Academic Press, an Imprint of Elsevier; 2020. p. 389–394.
21.
Choi HK, Atkinson K, Karlson EW, Willett W, Curhan G. Purine-rich foods, dairy and protein intake, and the risk of gout in men. N Engl J Med. 2004;350(11):1093–103.CrossRefPubMed
22.
23.
Rattan P, Penrice DD, Ahn JC, Ferrer A, Patnaik M, Shah VH, Kamath PS, Mangaonkar AA, Simonetto DA. Inverse Association of Telomere Length With Liver Disease and Mortality in the US Population. Hepatol Commun. 2022;6(2):399–410.CrossRefPubMed
24.
Tian X, Xue B, Wang B, Lei R, Shan X, Niu J, Luo B. Physical activity reduces the role of blood cadmium on depression: a cross-sectional analysis with NHANES data. Environ Pollut. 2022;304:119211.CrossRefPubMed
25.
Levey AS, Stevens LA, Schmid CH, Zhang YL, Castro AF 3rd, Feldman HI, Kusek JW, Eggers P, Van Lente F, Greene T, et al. A new equation to estimate glomerular filtration rate. Ann Internal Med. 2009;150(9):604–12.CrossRef
26.
Bakris G, Ali W, Parati G. ACC/AHA Versus ESC/ESH on Hypertension Guidelines: JACC Guideline Comparison. J Am Coll Cardiol. 2019;73(23):3018–26.CrossRefPubMed
27.
Cosentino F, Grant PJ, Aboyans V, Bailey CJ, Ceriello A, Delgado V, Federici M, Filippatos G, Grobbee DE, Hansen TB, et al. 2019 ESC Guidelines on diabetes, pre-diabetes, and cardiovascular diseases developed in collaboration with the EASD. Eur Heart J. 2020;41(2):255–323.CrossRefPubMed
28.
Grundy SM, Stone NJ, Bailey AL, Beam C, Birtcher KK, Blumenthal RS, Braun LT, de Ferranti S, Faiella-Tommasino J, Forman DE, et al. 2018 AHA/ACC/AACVPR/AAPA/ABC/ACPM/ADA/AGS/APhA/ASPC/NLA/PCNA Guideline on the Management of Blood Cholesterol: Executive Summary: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines. Circulation. 2019;139(25):e1046–81.PubMed
29.
Nelson RH. Hyperlipidemia as a risk factor for cardiovascular disease. Prim Care. 2013;40(1):195–211.CrossRefPubMed
30.
31.
Barr DB, Wilder LC, Caudill SP, Gonzalez AJ, Needham LL, Pirkle JL. Urinary creatinine concentrations in the US population: implications for urinary biologic monitoring measurements. Environ Health Perspect. 2004;113(2):192–200.CrossRefPubMedCentral
32.
33.
Ma L, Hu J, Li J, Yang Y, Zhang L, Zou L, Gao R, Peng C, Wang Y, Luo T, et al. Bisphenol A promotes hyperuricemia via activating xanthine oxidase. FASEB J. 2018;32(2):1007–16.CrossRefPubMed
34.
Asimakopoulos AG, Xue J, De Carvalho BP, Iyer A, Abualnaja KO, Yaghmoor SS, Kumosani TA, Kannan K. Urinary biomarkers of exposure to 57 xenobiotics and its association with oxidative stress in a population in Jeddah. Saudi Arabia Environ Res. 2016;150:573–81.CrossRefPubMed
35.
Liao C, Liu F, Alomirah H, Loi VD, Mohd MA, Moon HB, Nakata H, Kannan K. Bisphenol S in urine from the United States and seven Asian countries: occurrence and human exposures. Environ Sci Technol. 2012;46(12):6860–6.CrossRefPubMedADS
36.
Gayrard V, Lacroix MZ, Grandin FC, Collet SH, Mila H, Viguié C, Gély CA, Rabozzi B, Bouchard M, Léandri R, et al. Oral Systemic Bioavailability of Bisphenol A and Bisphenol S in Pigs. Environ Health Perspect. 2019;127(7):77005.CrossRefPubMed
37.
Rosenmai AK, Dybdahl M, Pedersen M. Alice van Vugt-Lussenburg BM, Wedebye EB, Taxvig C, Vinggaard AM: Are structural analogues to bisphenol a safe alternatives? Toxicol Sci. 2014;139(1):35–47.CrossRefPubMed
38.
39.
Vandenberg LN, Maffini MV, Sonnenschein C, Rubin BS, Soto AM. Bisphenol-A and the great divide: a review of controversies in the field of endocrine disruption. Endocr Rev. 2009;30(1):75–95.CrossRefPubMedPubMedCentral
40.
Vandenberg LN, Colborn T, Hayes TB, Heindel JJ, Jacobs DR Jr, Lee DH, Shioda T, Soto AM, vom Saal FS, Welshons WV, et al. Hormones and endocrine-disrupting chemicals: low-dose effects and nonmonotonic dose responses. Endocr Rev. 2012;33(3):378–455.CrossRefPubMedPubMedCentral
41.
Nickel S, Mahringer A. The xenoestrogens ethinylestradiol and bisphenol A regulate BCRP at the blood-brain barrier of rats. Xenobiotica. 2014;44(11):1046–54.CrossRefPubMed
42.
Sieppi E, Vähäkangas K, Rautio A, Ietta F, Paulesu L, Myllynen P. The xenoestrogens, bisphenol A and para-nonylphenol, decrease the expression of the ABCG2 transporter protein in human term placental explant cultures. Mol Cell Endocrinol. 2016;429:41–9.CrossRefPubMed
43.
Bao L, Zhao C, Feng L, Zhao Y, Duan S, Qiu M, Wu K, Zhang N, Hu X, Fu Y. Ferritinophagy is involved in Bisphenol A-induced ferroptosis of renal tubular epithelial cells through the activation of the AMPK-mTOR-ULK1 pathway. Food Chem Toxicol. 2022;163:112909.CrossRefPubMed
44.
Yoo MH, Lee SJ, Kim W, Kim Y, Kim YB, Moon KS, Lee BS. Bisphenol A impairs renal function by reducing Na(+)/K(+)-ATPase and F-actin expression, kidney tubule formation in vitro and in vivo. Ecotoxicol Environ Saf. 2022;246:114141.CrossRefPubMed
45.
Huang M, Liu S, Fu L, Jiang X, Yang M. Bisphenol A and its analogues bisphenol S, bisphenol F and bisphenol AF induce oxidative stress and biomacromolecular damage in human granulosa KGN cells. Chemosphere. 2020;253:126707.CrossRefPubMedADS
46.
Zhang L, Spencer KL, Voruganti VS, Jorgensen NW, Fornage M, Best LG, Brown-Gentry KD, Cole SA, Crawford DC, Deelman E. Association of functional polymorphism rs2231142 (Q141K) in the ABCG2 gene with serum uric acid and gout in 4 US populations: the PAGE Study. Am J Epidemiol. 2013;177(9):923–32.CrossRefPubMedPubMedCentral
47.
Bhole V, de Vera M, Rahman MM, Krishnan E, Choi H. Epidemiology of gout in women: Fifty-two–year followup of a prospective cohort. Arthritis Rheum. 2010;62(4):1069–76.CrossRefPubMed
Metadata
Title
Bisphenol A and its alternatives bisphenol S and F exposure with serum uric acid levels, hyperuricemia, and gout prevalence among US adults: a nationally representative cross-sectional study
Authors
Shunli Jiang
Yongxin Wang
Zengliang Wang
Yaru Xu
Xi Li
Mingjia Sun
Bo Li
Publication date
01-12-2024
Publisher
BioMed Central
Published in
BMC Public Health / Issue 1/2024
Electronic ISSN: 1471-2458
DOI
https://doi.org/10.1186/s12889-024-17883-6

Other articles of this Issue 1/2024

BMC Public Health 1/2024 Go to the issue

Publisher Correction

Publisher Correction: Association of urinary chlorpyrifos, paraquat, and cyproconazole levels with the severity of fatty liver based on MRI

Research

Does “National Civilized City” policy mitigate air pollution in China? A spatial Durbin difference-in-differences analysis

Research

Knowledge, attitude, and practice of diabetes in patients with and without sight-threatening diabetic retinopathy from two secondary eye care centres in India

Research

Mediating role of birth at a baby-friendly hospital in the association between parental socioeconomic status and infant exclusive breastfeeding at six months old

Research

Pneumococcal vaccine uptake among high-risk adults and children in Italy: results from the OBVIOUS project survey

Research

Novel subgroups of obesity and their association with outcomes: a data-driven cluster analysis