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Published in: Medical Microbiology and Immunology 3/2005

01-05-2005 | Opinion

Bioterrorism: is it a real threat?

Authors: René Gottschalk, Wolfgang Preiser

Published in: Medical Microbiology and Immunology | Issue 3/2005

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Abstract

The Geneva Protocol of 1925 commits the signatory nations to refraining from the use of biological weapons. However, the terrorist assaults of September 2001 and, subsequently, the anthrax-containing letters are cause for great concerns: new threats to the security of nations are expected, as terrorist organizations seem to increasingly explore novel ways of spreading terror.
In this context, naturally emerging diseases such as SARS, monkeypox or West Nile fever assume new importance because it is difficult to distinguish between natural epidemics and possible bioweapon assaults. Great efforts on the part of governments and public health authorities are necessary to counteract these threats.
Literature
1.
go back to reference Beeching NJ, Dance DAB, Miller ARO, Spencer RC (2002) Biological warfare and bioterrorism. Br Med J 324:336–339CrossRef Beeching NJ, Dance DAB, Miller ARO, Spencer RC (2002) Biological warfare and bioterrorism. Br Med J 324:336–339CrossRef
2.
go back to reference Berger A, Drosten C, Doerr HW, Stürmer M, Preiser W (2004) Severe acute respiratory syndrome (SARS)—paradigm of an emerging viral infection. J Clin Virol. 29:13–22 Berger A, Drosten C, Doerr HW, Stürmer M, Preiser W (2004) Severe acute respiratory syndrome (SARS)—paradigm of an emerging viral infection. J Clin Virol. 29:13–22
3.
go back to reference Bravata DM, Sundaram V, McDonald KM, Smith WM, Szeto H, Schleinitz MD, Owens DK (2004) Evaluating detection and diagnostic decision support systems for bioterrorism response. Emerg Infect Dis 10:100–108 Bravata DM, Sundaram V, McDonald KM, Smith WM, Szeto H, Schleinitz MD, Owens DK (2004) Evaluating detection and diagnostic decision support systems for bioterrorism response. Emerg Infect Dis 10:100–108
4.
go back to reference Bundesministerium für Gesundheit und Soziale Sicherung (BMGS) Pressemitteilung 4/2003. Available at: http://www.bmgs.bund.de/deu/gra/aktuelles/pm/bmgs03/bmgs4_4340.cfm (accessed 25 May 2004) Bundesministerium für Gesundheit und Soziale Sicherung (BMGS) Pressemitteilung 4/2003. Available at: http://​www.​bmgs.​bund.​de/​deu/​gra/​aktuelles/​pm/​bmgs03/​bmgs4_​4340.​cfm (accessed 25 May 2004)
5.
go back to reference Bush LM, Abrams BH, Beall A, Johnson CC (2001) Index case of fatal inhalational anthrax due to bioterrorism in the United States. N Engl J Med 345:1607–1610CrossRefPubMed Bush LM, Abrams BH, Beall A, Johnson CC (2001) Index case of fatal inhalational anthrax due to bioterrorism in the United States. N Engl J Med 345:1607–1610CrossRefPubMed
6.
go back to reference Casadevall A, Pirofski LA (2004) The weapon potential of a microbe. Trends Microbiol 12:259–263PubMed Casadevall A, Pirofski LA (2004) The weapon potential of a microbe. Trends Microbiol 12:259–263PubMed
7.
go back to reference Centers for Disease Control and Prevention (1999) Outbreak of West Nile-like viral encephalitis—New York, 1999. MMWR Morb Mortal Wkly Rep 48:845–849PubMed Centers for Disease Control and Prevention (1999) Outbreak of West Nile-like viral encephalitis—New York, 1999. MMWR Morb Mortal Wkly Rep 48:845–849PubMed
8.
go back to reference Centers for Disease Control and Prevention (2001) Update: Investigation of anthrax associated with intentional exposure and interim public health guidelines, October 2001. MMWR Morb Mortal Wkly Rep 50:889–893PubMed Centers for Disease Control and Prevention (2001) Update: Investigation of anthrax associated with intentional exposure and interim public health guidelines, October 2001. MMWR Morb Mortal Wkly Rep 50:889–893PubMed
9.
go back to reference Centers for Disease Control and Prevention (2003) Bioterrorism Agents/Diseases; last modification November 19, 2003. Available at: http://www.bt.cdc.gov/agent/agentlist-category.asp (accessed 25 May 2004) Centers for Disease Control and Prevention (2003) Bioterrorism Agents/Diseases; last modification November 19, 2003. Available at: http://​www.​bt.​cdc.​gov/​agent/​agentlist-category.​asp (accessed 25 May 2004)
10.
go back to reference Centers for Disease Control and Prevention (2003) Smallpox vaccination and adverse reactions: guidance for clinicians. MMWR Morb Mortal Wkly Rep 52:1–28 Centers for Disease Control and Prevention (2003) Smallpox vaccination and adverse reactions: guidance for clinicians. MMWR Morb Mortal Wkly Rep 52:1–28
11.
go back to reference Centers for Disease Control and Prevention (2004) 2003 West Nile virus activity in the United States (reported as of May 21, 2004). Available from http://www.cdc.gov/ncidod/dvbid/westnile/surv&controlCaseCount03_detailed.htm (accessed 12 July 2004) Centers for Disease Control and Prevention (2004) 2003 West Nile virus activity in the United States (reported as of May 21, 2004). Available from http://​www.​cdc.​gov/​ncidod/​dvbid/​westnile/​surv&​controlCaseCount​03_​detailed.​htm (accessed 12 July 2004)
12.
14.
go back to reference Farber NJ, Aboff BM, Weiner J, Davis EB, Boyer EG, Ubel PA (2001) Physicians’ willingness to participate in the process of lethal injection for capital punishment. Ann Intern Med 135:884–888PubMed Farber NJ, Aboff BM, Weiner J, Davis EB, Boyer EG, Ubel PA (2001) Physicians’ willingness to participate in the process of lethal injection for capital punishment. Ann Intern Med 135:884–888PubMed
15.
go back to reference Fenner F, Henderson DA, Arita I, Ježek Z, Ladnyi ID (1988) Developments in vaccination and control between 1900 and 1966. In: Smallpox and its eradication, chapter 7. World Health Organization, Geneva Fenner F, Henderson DA, Arita I, Ježek Z, Ladnyi ID (1988) Developments in vaccination and control between 1900 and 1966. In: Smallpox and its eradication, chapter 7. World Health Organization, Geneva
16.
go back to reference Guarner J, Johnson BJ, Paddock CD, Shieh WJ, Goldsmith CS, Reynolds MG, Damon IK, Regnery RL, Zaki SR, the Veterinary Monkeypox Virus Working Group (2004) Monkeypox transmission and pathogenesis in prairie dogs. Emerg Infect Dis 10:426–431 Guarner J, Johnson BJ, Paddock CD, Shieh WJ, Goldsmith CS, Reynolds MG, Damon IK, Regnery RL, Zaki SR, the Veterinary Monkeypox Virus Working Group (2004) Monkeypox transmission and pathogenesis in prairie dogs. Emerg Infect Dis 10:426–431
17.
go back to reference Jernigan DB, Raghunathan PL, Bell BP, et al (2002) Investigation of bioterrorism-related anthrax, United States, 2001: epidemiologic findings. Emerg Infect Dis 8:1019–1028PubMed Jernigan DB, Raghunathan PL, Bell BP, et al (2002) Investigation of bioterrorism-related anthrax, United States, 2001: epidemiologic findings. Emerg Infect Dis 8:1019–1028PubMed
18.
go back to reference Jia XY, Briese T, Jordan I, Rambaut A, Chi HC, Mackenzie JS, Hall RA, Scherret J, Lipkin WI (1999) Genetic analysis of West Nile New York 1999 encephalitis virus. Lancet 354:1971–1972CrossRefPubMed Jia XY, Briese T, Jordan I, Rambaut A, Chi HC, Mackenzie JS, Hall RA, Scherret J, Lipkin WI (1999) Genetic analysis of West Nile New York 1999 encephalitis virus. Lancet 354:1971–1972CrossRefPubMed
19.
go back to reference Kelley M, Coghlan J (2003) Mixing bugs and bombs. Bull Atom Sci 59:24–31 Kelley M, Coghlan J (2003) Mixing bugs and bombs. Bull Atom Sci 59:24–31
20.
go back to reference Lanciotti RS, Roehrig JT, Deubel V, et al (1999) Origin of the West Nile virus responsible for an outbreak of encephalitis in the northeastern United States. Science 286:2333–2337CrossRefPubMed Lanciotti RS, Roehrig JT, Deubel V, et al (1999) Origin of the West Nile virus responsible for an outbreak of encephalitis in the northeastern United States. Science 286:2333–2337CrossRefPubMed
21.
go back to reference Ludwig B, Kraus FB, Allwinn R, Doerr HW, Preiser W (2003) Viral zoonoses—a threat under control? Intervirology 46:71–78CrossRefPubMed Ludwig B, Kraus FB, Allwinn R, Doerr HW, Preiser W (2003) Viral zoonoses—a threat under control? Intervirology 46:71–78CrossRefPubMed
22.
go back to reference Monaghan K (2003) SARS down but still a threat. National Intelligence Council Intelligence Community Assessment, August 2003. Available at: http://www.cia.gov/nic/special_sarsthreat.html (accessed 25 May 2004) Monaghan K (2003) SARS down but still a threat. National Intelligence Council Intelligence Community Assessment, August 2003. Available at: http://​www.​cia.​gov/​nic/​special_​sarsthreat.​html (accessed 25 May 2004)
23.
go back to reference Müllbacher A, Lobigs M (2001) Creation of killer poxvirus could have been predicted. J Virol 75:8353–8355CrossRefPubMed Müllbacher A, Lobigs M (2001) Creation of killer poxvirus could have been predicted. J Virol 75:8353–8355CrossRefPubMed
24.
go back to reference Nash D, Mostashari F, Fine A, et al (2001) The outbreak of West Nile virus infection in the New York City area in 1999. N Engl J Med 344:1807–1814CrossRefPubMed Nash D, Mostashari F, Fine A, et al (2001) The outbreak of West Nile virus infection in the New York City area in 1999. N Engl J Med 344:1807–1814CrossRefPubMed
25.
go back to reference Petro JB, Plasse TR, Mcnulty JA (2003) Biotechnology: impact on biological warfare and biodefense. Biosecur Bioterror 1:161–168CrossRefPubMed Petro JB, Plasse TR, Mcnulty JA (2003) Biotechnology: impact on biological warfare and biodefense. Biosecur Bioterror 1:161–168CrossRefPubMed
26.
go back to reference Protocol for the Prohibition of the Use in War of Asphyxiating, Poisonous, or other Gases, and of Bacteriological Methods of Warfare (Geneva Protocol, 1925). Opened for signature: 17 June 1925, entered into force: 8 February 1928. Available at: http://www.sussex.ac.uk/spru/hsp/Genev-Prot.html (accessed 21 June 2004) Protocol for the Prohibition of the Use in War of Asphyxiating, Poisonous, or other Gases, and of Bacteriological Methods of Warfare (Geneva Protocol, 1925). Opened for signature: 17 June 1925, entered into force: 8 February 1928. Available at: http://​www.​sussex.​ac.​uk/​spru/​hsp/​Genev-Prot.​html (accessed 21 June 2004)
27.
go back to reference Reed KD, Melski JW, Graham MB, et al (2004) The detection of monkeypox in humans in the Western hemisphere. N Engl J Med. 350:342–350 Reed KD, Melski JW, Graham MB, et al (2004) The detection of monkeypox in humans in the Western hemisphere. N Engl J Med. 350:342–350
28.
go back to reference Richardson L (2004) Buying biosafety—is the price right? N Engl J Med 350:2121–2123 Richardson L (2004) Buying biosafety—is the price right? N Engl J Med 350:2121–2123
29.
go back to reference Rotz LD, Khan AS, Lillibridge SR, Ostroff SM, Hughes JM (2002) Public health assessment of potential biological terrorism agents. Emerg Infect Dis 8:225–230PubMed Rotz LD, Khan AS, Lillibridge SR, Ostroff SM, Hughes JM (2002) Public health assessment of potential biological terrorism agents. Emerg Infect Dis 8:225–230PubMed
30.
go back to reference Rumyantsev SN (2004) The best defence against bioweapons has already been invented by evolution. Infect Genet Evol 4:159–166PubMed Rumyantsev SN (2004) The best defence against bioweapons has already been invented by evolution. Infect Genet Evol 4:159–166PubMed
31.
32.
go back to reference Takahashi H, Keim P, Kaufmann AF, Keys C, Smith KL, Taniguchi K, Inouye S, Kurata T (2004) Bacillus anthracis incident, Kameido, Tokyo, 1993. Emerg Infect Dis 10:117–120 Takahashi H, Keim P, Kaufmann AF, Keys C, Smith KL, Taniguchi K, Inouye S, Kurata T (2004) Bacillus anthracis incident, Kameido, Tokyo, 1993. Emerg Infect Dis 10:117–120
33.
go back to reference The European Agency for the Evaluation of Medicinal Products (2002) EMEA/CPMP guidance document on use of medicinal products for treatment and prophylaxis of biological agents that might be used as weapons of bioterrorism. CPMP/4048/01. Available at: http://www.emea.eu.int/htms/human/bioterror/bioterror.htm (accessed 18 July 2004) The European Agency for the Evaluation of Medicinal Products (2002) EMEA/CPMP guidance document on use of medicinal products for treatment and prophylaxis of biological agents that might be used as weapons of bioterrorism. CPMP/4048/01. Available at: http://​www.​emea.​eu.​int/​htms/​human/​bioterror/​bioterror.​htm (accessed 18 July 2004)
34.
go back to reference Wirtz A, Gottschalk R, Weber HJ (2003) Management of an attack with biological agents. Reflections on the necessary infrastructure for states and towns. Bundesgesundheitsbl Gesundheitsforsch Gesundheitsschutz 46:1001–1009CrossRef Wirtz A, Gottschalk R, Weber HJ (2003) Management of an attack with biological agents. Reflections on the necessary infrastructure for states and towns. Bundesgesundheitsbl Gesundheitsforsch Gesundheitsschutz 46:1001–1009CrossRef
35.
go back to reference World Health Organization (2002) Smallpox eradication: destruction of variola virus stocks. Report by the Secretariat. Available at: http://www.who.int/gb/ebwha/pdf_files/WHA55/ea5521.pdf (accessed 25 May 2004) World Health Organization (2002) Smallpox eradication: destruction of variola virus stocks. Report by the Secretariat. Available at: http://​www.​who.​int/​gb/​ebwha/​pdf_​files/​WHA55/​ea5521.​pdf (accessed 25 May 2004)
36.
go back to reference World Health Organization (2003) Laboratory safety manual. Second edition (revised). WHO/CDS/CSR/LYO/2003.4. Interim guidelines. World Health Organization, Geneva 2003 World Health Organization (2003) Laboratory safety manual. Second edition (revised). WHO/CDS/CSR/LYO/2003.4. Interim guidelines. World Health Organization, Geneva 2003
37.
go back to reference World Health Organization (2004) Public health response to biological and chemical weapons: WHO guidance, 2nd edn. World Health Organization, Geneva 2004. Available at: http://www.who.int/csr/delibepidemics/biochemguide/en/ (accessed 18 July 2004) World Health Organization (2004) Public health response to biological and chemical weapons: WHO guidance, 2nd edn. World Health Organization, Geneva 2004. Available at: http://​www.​who.​int/​csr/​delibepidemics/​biochemguide/​en/​ (accessed 18 July 2004)
Metadata
Title
Bioterrorism: is it a real threat?
Authors
René Gottschalk
Wolfgang Preiser
Publication date
01-05-2005
Publisher
Springer-Verlag
Published in
Medical Microbiology and Immunology / Issue 3/2005
Print ISSN: 0300-8584
Electronic ISSN: 1432-1831
DOI
https://doi.org/10.1007/s00430-004-0228-z

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