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02-06-2023 | Biomarkers | Review Article

Tumor Microenvironment: a Therapeutic Aid in Cancer

Authors: Sakshi Tiwari, Bilal Siddiqui, Shilpy Singh, Afsana Praveen

Published in: Indian Journal of Surgery | Issue 1/2024

Abstract

The tumorigenesis and cancer cell progression are complicated processes starting from primary tumor formation by dysregulated vascularization to systemic metastasis. The tumor tends to thrive in a microenvironment that anchors its growth, progression, activation, and malignancies in the nearby tissues. The tumor microenvironment (TME) comprises different types of immune cells such as neutrophils, dendritic cells, macrophages, and fibroblasts, which have important functions in the activation of tumor suppression, and an extracellular matrix with cytokines, chemokines, and interleukins for cell signaling. This microenvironment niche has emerged as a significant way to target tumor cells and is implied in cancer immunotherapy techniques. The deeper insights into diverse cell types of cancer, carcinoma ligands, spatial arrangements, and leaky blood vessels have provided favorable circumstances for modulating therapeutic conciliation. This mini-review discusses the nature of the TME, its varied constituents, and its role in cancer therapeutics to target tumors. Overall, this review provides a brief account of the tumor microenvironment and its promising role in cancer treatment.

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Title: Tumor Microenvironment: a Therapeutic Aid in Cancer
Authors: Sakshi Tiwari
Bilal Siddiqui
Shilpy Singh
Afsana Praveen
Publication date: 02-06-2023
Publisher: Springer India
Keyword: Biomarkers
Published in: Indian Journal of Surgery / Issue 1/2024
Print ISSN: 0972-2068
Electronic ISSN: 0973-9793
DOI: https://doi.org/10.1007/s12262-023-03828-7

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Tumor Microenvironment: a Therapeutic Aid in Cancer

Abstract

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Abstract

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