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Cancer Cell International

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Open Access 01-12-2019 | Biomarkers | Primary research

Prognostic value of Lin28A and Lin28B in various human malignancies: a systematic review and meta-analysis

Authors: Jiayi Zhang, Aiming Xu, Chenkui Miao, Jie Yang, Min Gu, Ninghong Song

Published in: Cancer Cell International | Issue 1/2019

Abstract

Background

The mammalian homologs of Lin-28, Lin28 (also called Lin28A) and Lin28B, are promising cancer biomarkers. This meta-analysis was performed to evaluate the prognostic values of Lin28A and Lin28B in multiple human malignancies.

Methods

Systematic searches of the PubMed, Web of Science and Embase were used to identify relevant studies. Pooled hazard ratios (HRs) with 95% confidence intervals (CI) for overall survival (OS), recurrence-free survival (RFS), disease-free survival (DFS), or progression-free survival (PFS) were respectively calculated.

Results

3772 Lin28A-associated patients and 1730 Lin28B-related cases were ultimately enrolled in this meta-analysis. The elevated expression level of Lin28A was significantly associated with poor OS (HR = 1.60, P < 0.001) and poor RFS/DFS/PFS (HR = 1.62, P < 0.001) in patients with malignancies. Lin28B overexpression significantly correlated with unfavorable OS (HR = 1.72, P < 0.001) and RFS/DFS/PFS (HR = 2.35, P < 0.001) of human malignancies.

Conclusions

Lin28A and Lin28B possess significant prognostic values in various human malignancies. Overexpression of Lin28A or Lin28B suggests poor prognosis for cancer patients.

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Title: Prognostic value of Lin28A and Lin28B in various human malignancies: a systematic review and meta-analysis
Authors: Jiayi Zhang
Aiming Xu
Chenkui Miao
Jie Yang
Min Gu
Ninghong Song
Publication date: 01-12-2019
Publisher: BioMed Central
Keyword: Biomarkers
Published in: Cancer Cell International / Issue 1/2019
Electronic ISSN: 1475-2867
DOI: https://doi.org/10.1186/s12935-019-0788-z

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