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European Archives of Oto-Rhino-Laryngology

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01-05-2020 | Biomarkers | Laryngology

Identification of core biomarkers associated with pathogenesis and prognostic outcomes of laryngeal squamous-cell cancer using bioinformatics analysis

Authors: Wei Chen, Lianming Liao, Haichun Lai, Xuehan Yi, Desheng Wang

Published in: European Archives of Oto-Rhino-Laryngology | Issue 5/2020

Abstract

Purpose

Despite advances in the treatment of laryngeal squamous-cell carcinoma (LSCC), the survival rate of LSCC remains poor. Thereby, it is urgent to identify novel diagnostic and prognostic biomarkers for LSCC. The study aimed to identify potential core genes associated with the pathogenesis and prognosis of LSCC.

Methods

Differentially expressed genes between LSCC and normal laryngeal tissue samples were screened by an integrated analysis of data from GEO and TCGA databases. Core genes related to the pathogenesis and prognosis of LSCC were identified by employing protein–protein interaction network and Cox proportional hazards model analyses.

Results

Ten hub genes (AURKA, AURKB, CDC45, KIF2C, NDC80, EXO1, TYMS, RAD51AP1, ITGA3, and UBE2T) that might be highly related to the pathogenesis of LSCC were identified. An eight-gene prognostic signature consisted of ZG16B, STATH, RTN4R, MSRA, CBX8, SLC5A1, EFNB1 and CNTFR was constructed with a good performance in predicting overall survivals.

Conclusion

Our findings might shed some new light on the pathogenesis of LSCC and help identify new therapeutic targets of LSCC.

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Title: Identification of core biomarkers associated with pathogenesis and prognostic outcomes of laryngeal squamous-cell cancer using bioinformatics analysis
Authors: Wei Chen
Lianming Liao
Haichun Lai
Xuehan Yi
Desheng Wang
Publication date: 01-05-2020
Publisher: Springer Berlin Heidelberg
Keyword: Biomarkers
Published in: European Archives of Oto-Rhino-Laryngology / Issue 5/2020
Print ISSN: 0937-4477
Electronic ISSN: 1434-4726
DOI: https://doi.org/10.1007/s00405-020-05856-5

At a glance: The STEP trials

Springer Medicine

Identification of core biomarkers associated with pathogenesis and prognostic outcomes of laryngeal squamous-cell cancer using bioinformatics analysis

Abstract

Purpose

Methods

Results

Conclusion

At a glance: The STEP trials

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusion

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