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Malaria Journal
Published in: Malaria Journal 1/2013

Open Access 01-12-2013 | Review

Biochemical and immunological mechanisms by which sickle cell trait protects against malaria

Authors: Lauren Gong, Sunil Parikh, Philip J Rosenthal, Bryan Greenhouse

Published in: Malaria Journal | Issue 1/2013

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Abstract

Sickle cell trait (HbAS) is the best-characterized genetic polymorphism known to protect against falciparum malaria. Although the protective effect of HbAS against malaria is well known, the mechanism(s) of protection remain unclear. A number of biochemical and immune-mediated mechanisms have been proposed, and it is likely that multiple complex mechanisms are responsible for the observed protection. Increased evidence for an immune component of protection as well as novel mechanisms, such as enhanced tolerance to disease mediated by HO-1 and reduced parasitic growth due to translocation of host micro-RNA into the parasite, have recently been described. A better understanding of relevant mechanisms will provide valuable insight into the host-parasite relationship, including the role of the host immune system in protection against malaria.
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Metadata
Title
Biochemical and immunological mechanisms by which sickle cell trait protects against malaria
Authors
Lauren Gong
Sunil Parikh
Philip J Rosenthal
Bryan Greenhouse
Publication date
01-12-2013
Publisher
BioMed Central
Published in
Malaria Journal / Issue 1/2013
Electronic ISSN: 1475-2875
DOI
https://doi.org/10.1186/1475-2875-12-317

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