Skip to main content
Top
Published in: Medical Oncology 1/2011

01-12-2011 | Orginal Paper

Bilateral papilledema on sunitinib therapy for advanced renal cell carcinoma

Authors: Jaclyn Yoong, Geoffrey Chong, K. Hamilton

Published in: Medical Oncology | Special Issue 1/2011

Login to get access

Abstract

We report the case of a 59-year-old man with advanced renal cell carcinoma who developed bilateral papilledema while on therapy with sunitinib, a multi-targeted tyrosine kinase inhibitor (TKI). While papilledema has been reported in association with another TKI (imatinib), the association between sunitinib and papilledema has not previously been reported in the literature.
Literature
1.
go back to reference Oudard S, George D, Medioni J, Motzer R. Treatment options in renal cell carcinoma: past, present and future. Ann Oncol. 2007;18(Suppl 10):x25–31.PubMedCrossRef Oudard S, George D, Medioni J, Motzer R. Treatment options in renal cell carcinoma: past, present and future. Ann Oncol. 2007;18(Suppl 10):x25–31.PubMedCrossRef
2.
go back to reference Motzer RJ, Bukowski RM. Targeted therapy for metastatic renal cell carcinoma. J Clin Oncol. 2006;24(35):5601–8.PubMedCrossRef Motzer RJ, Bukowski RM. Targeted therapy for metastatic renal cell carcinoma. J Clin Oncol. 2006;24(35):5601–8.PubMedCrossRef
3.
go back to reference Motzer RJ, et al. Sunitinib in patients with metastatic renal cell carcinoma. JAMA. 2006;295(21):2516–24.PubMedCrossRef Motzer RJ, et al. Sunitinib in patients with metastatic renal cell carcinoma. JAMA. 2006;295(21):2516–24.PubMedCrossRef
4.
go back to reference Motzer RJ, et al. Activity of SU11248, a multitargeted inhibitor of vascular endothelial growth factor receptor and platelet-derived growth factor receptor, in patients with metastatic renal cell carcinoma. J Clin Oncol. 2006;24(1):16–24. Epub 2005 Dec 5.PubMedCrossRef Motzer RJ, et al. Activity of SU11248, a multitargeted inhibitor of vascular endothelial growth factor receptor and platelet-derived growth factor receptor, in patients with metastatic renal cell carcinoma. J Clin Oncol. 2006;24(1):16–24. Epub 2005 Dec 5.PubMedCrossRef
5.
go back to reference Motzer RJ, et al. Sunitinib versus interferon alfa in metastatic renal-cell carcinoma. N Engl J Med. 2007;356(2):115–24.PubMedCrossRef Motzer RJ, et al. Sunitinib versus interferon alfa in metastatic renal-cell carcinoma. N Engl J Med. 2007;356(2):115–24.PubMedCrossRef
6.
go back to reference Porta C, Szczylik C. Tolerability of first-line therapy for metastatic renal cell carcinoma. Cancer Treat Rev. 2009;35(3):297–307. Epub 2009 Feb 26.PubMedCrossRef Porta C, Szczylik C. Tolerability of first-line therapy for metastatic renal cell carcinoma. Cancer Treat Rev. 2009;35(3):297–307. Epub 2009 Feb 26.PubMedCrossRef
7.
go back to reference Hutson TE, et al. Targeted therapies for metastatic renal cell carcinoma: an overview of toxicity and dosing strategies. Oncologist. 2008;13(10):1084–96. Epub 2008 Oct 6.PubMedCrossRef Hutson TE, et al. Targeted therapies for metastatic renal cell carcinoma: an overview of toxicity and dosing strategies. Oncologist. 2008;13(10):1084–96. Epub 2008 Oct 6.PubMedCrossRef
8.
go back to reference Chen A, Agarwal N. Reversible posterior leucoencephalopathy syndrome associated with sunitinib. Intern Med J. 2009;39(5):341–2. Epub 2009 Apr 20.PubMedCrossRef Chen A, Agarwal N. Reversible posterior leucoencephalopathy syndrome associated with sunitinib. Intern Med J. 2009;39(5):341–2. Epub 2009 Apr 20.PubMedCrossRef
9.
go back to reference Kapiteijn E, et al. Sunitinib induced hypertension, thrombotic microangiopathy and reversible posterior leukencephalopathy syndrome. Ann Oncol. 2007;18(10):1745–7.PubMedCrossRef Kapiteijn E, et al. Sunitinib induced hypertension, thrombotic microangiopathy and reversible posterior leukencephalopathy syndrome. Ann Oncol. 2007;18(10):1745–7.PubMedCrossRef
10.
go back to reference Martín G, Bellido L, Crux JJ. Reversible posterior leukoencephalopathy syndrome induced by sunitinib. J Clin Oncol. 2007;25(23):3559.PubMedCrossRef Martín G, Bellido L, Crux JJ. Reversible posterior leukoencephalopathy syndrome induced by sunitinib. J Clin Oncol. 2007;25(23):3559.PubMedCrossRef
11.
go back to reference Lee VH, Wijdicks EF, Manno EM, Rabinstein AA. Clinical spectrum of reversible posterior leukoencephalopathy syndrome. Arch Neurol. 2008;65(2):205–10.PubMedCrossRef Lee VH, Wijdicks EF, Manno EM, Rabinstein AA. Clinical spectrum of reversible posterior leukoencephalopathy syndrome. Arch Neurol. 2008;65(2):205–10.PubMedCrossRef
12.
go back to reference Hinchey J, et al. A reversible posterior leukoencephalopathy syndrome. N Engl J Med. 1996;334(8):494–500.PubMedCrossRef Hinchey J, et al. A reversible posterior leukoencephalopathy syndrome. N Engl J Med. 1996;334(8):494–500.PubMedCrossRef
13.
go back to reference Schiffer CA. BCR-ABL tyrosine kinase inhibitors for chronic myelogenous leukemia. N Engl J Med. 2007;357(3):258–65.PubMedCrossRef Schiffer CA. BCR-ABL tyrosine kinase inhibitors for chronic myelogenous leukemia. N Engl J Med. 2007;357(3):258–65.PubMedCrossRef
14.
go back to reference Kwon SI, Lee DH, Kim YJ. Optic disc edema as a possible complication of Imatinib mesylate (Gleevec). Jpn J Ophthalmol. 2008;52(4):331–3. Epub 2008 Sep 5.PubMedCrossRef Kwon SI, Lee DH, Kim YJ. Optic disc edema as a possible complication of Imatinib mesylate (Gleevec). Jpn J Ophthalmol. 2008;52(4):331–3. Epub 2008 Sep 5.PubMedCrossRef
15.
go back to reference Breccia M, et al. Ocular side effects in chronic myeloid leukemia patients treated with imatinib. Leuk Res. 2008;32(7):1022–5. Epub 2007 Dec 3.PubMedCrossRef Breccia M, et al. Ocular side effects in chronic myeloid leukemia patients treated with imatinib. Leuk Res. 2008;32(7):1022–5. Epub 2007 Dec 3.PubMedCrossRef
16.
go back to reference Larson JS, Bergstrom LK, Cameron JD, Erickson LA, Grimm TE. Severe periorbital edema secondary to imatinib mesylate for chronic myelogenous leukemia. Arch Ophthal. 2007;125(7):985–6.PubMedCrossRef Larson JS, Bergstrom LK, Cameron JD, Erickson LA, Grimm TE. Severe periorbital edema secondary to imatinib mesylate for chronic myelogenous leukemia. Arch Ophthal. 2007;125(7):985–6.PubMedCrossRef
17.
go back to reference Esmaeli B, et al. Severe periorbital edema secondary to STI571 (Gleevec). Cancer. 2002;95(4):881–7.PubMedCrossRef Esmaeli B, et al. Severe periorbital edema secondary to STI571 (Gleevec). Cancer. 2002;95(4):881–7.PubMedCrossRef
18.
go back to reference Kusumi E, et al. Visual disturbance due to retinal edema as a complication of imatinib. Leukemia. 2004;18(6):1138–9.PubMedCrossRef Kusumi E, et al. Visual disturbance due to retinal edema as a complication of imatinib. Leukemia. 2004;18(6):1138–9.PubMedCrossRef
Metadata
Title
Bilateral papilledema on sunitinib therapy for advanced renal cell carcinoma
Authors
Jaclyn Yoong
Geoffrey Chong
K. Hamilton
Publication date
01-12-2011
Publisher
Springer US
Published in
Medical Oncology / Issue Special Issue 1/2011
Print ISSN: 1357-0560
Electronic ISSN: 1559-131X
DOI
https://doi.org/10.1007/s12032-010-9719-5

Other articles of this Special Issue 1/2011

Medical Oncology 1/2011 Go to the issue
Live Webinar | 27-06-2024 | 18:00 (CEST)

Keynote webinar | Spotlight on medication adherence

Live: Thursday 27th June 2024, 18:00-19:30 (CEST)

WHO estimates that half of all patients worldwide are non-adherent to their prescribed medication. The consequences of poor adherence can be catastrophic, on both the individual and population level.

Join our expert panel to discover why you need to understand the drivers of non-adherence in your patients, and how you can optimize medication adherence in your clinics to drastically improve patient outcomes.

Prof. Kevin Dolgin
Prof. Florian Limbourg
Prof. Anoop Chauhan
Developed by: Springer Medicine
Obesity Clinical Trial Summary

At a glance: The STEP trials

A round-up of the STEP phase 3 clinical trials evaluating semaglutide for weight loss in people with overweight or obesity.

Developed by: Springer Medicine

Highlights from the ACC 2024 Congress

Year in Review: Pediatric cardiology

Watch Dr. Anne Marie Valente present the last year's highlights in pediatric and congenital heart disease in the official ACC.24 Year in Review session.

Year in Review: Pulmonary vascular disease

The last year's highlights in pulmonary vascular disease are presented by Dr. Jane Leopold in this official video from ACC.24.

Year in Review: Valvular heart disease

Watch Prof. William Zoghbi present the last year's highlights in valvular heart disease from the official ACC.24 Year in Review session.

Year in Review: Heart failure and cardiomyopathies

Watch this official video from ACC.24. Dr. Biykem Bozkurt discusses last year's major advances in heart failure and cardiomyopathies.